Abstract
Recent findings in a sheep model of atrial fibrillation support the hypothesis that an organized micro-reentry could be the maintaining mechanism of the arrhythmia (mother wavelet). According to these studies we constructed a two dimensional computer model of tissue in the region around a pair of pulmonary vein ostia and investigated anchoring of a reentry wave at these ostia. We used the Luo Rudy phase I ionic current model to describe membrane kinetics and generated two different stages of electrical remodelling of the cells by varying the slow inward calcium current. Our attempt to initiate a stable reentry failed for cells with higher action potential duration and higher rate adaption. By simulating a higher stadium of electrical remodelling we finally were successful, and we were able to produce a periodic reentry. This led us to the conclusion that a low rate adaption (high electrical remodelling) facilitates organized activity in the atria.
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Wieser, L., Fischer, G., Hintringer, F., Ho, S.Y., Tilg, B. (2005). Reentry Anchoring at a Pair of Pulmonary Vein Ostia. In: Frangi, A.F., Radeva, P.I., Santos, A., Hernandez, M. (eds) Functional Imaging and Modeling of the Heart. FIMH 2005. Lecture Notes in Computer Science, vol 3504. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11494621_19
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DOI: https://doi.org/10.1007/11494621_19
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-26161-2
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