Abstract
The presence of dendritic spikes in pyramidal cells modifies the classical concepts of dendritic integration but the strong non-linear behaviour makes difficult the experimental study. A number of factors control their initiation and spread. We explore here with an experimentally calibrated model the relation of these spikes to cell output during synchronous input and spontaneous firing. A small number of firing dendrites within a reduced timescale is enough to cause cell output. We show that dendritic inhibition and modulation of the excitability at the main apical shaft offer a wide variety of input-output relations.
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© 2005 Springer-Verlag Berlin Heidelberg
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Ibarz, J.M., Makarova, I., Cepeda, I.R., Herreras, O. (2005). Rules and Roles of Dendritic Spikes in CA1 Pyramidal Cells: A Computational Study. In: Mira, J., Álvarez, J.R. (eds) Mechanisms, Symbols, and Models Underlying Cognition. IWINAC 2005. Lecture Notes in Computer Science, vol 3561. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11499220_15
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DOI: https://doi.org/10.1007/11499220_15
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