Abstract
In this study, a computational method is presented to simulate the hemodynamics of patients after the Fontan procedure. The short-term feedback control models are implemented to assess the hemodynamic responses of the patients exposed to stresses such as gravity or hemorrhage. To construct the base line state of the Fontan model, we assume an increase in venous tone, an increase in heart rate, and an increase in systemic resistance all of which are based on clinical observations. For the verification of the present method we simulate a lower body negative pressure (LBNP) test and hemorrhage (20% blood volume loss). Both simulation results are compared to experimental data from the literature. Furthermore, it is shown that cardiac output decreases when the shunt resistance increases.
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References
Fontan, F., and Baudet, E., 1971, “Sugical repair of tricuspid atresia,” Thorax, Vol. 26, pp. 240–248.
Gale, A. W., Danielsson, G. K., McGoon, D. C., and Mair, D. D., 1979, “Modified Fontan operation for univentricular heart and complicated congenital lesions,” J. Thorac. Cardiovas. Surg., Vol. 78, pp. 831–838.
Pennati G, Migliavacca F, Dubini G, Pietrabissa R, Fumero R, de Leval MR., “Use of mathematical model to predict hemodynamics in cavopulmonary anastomosis with persistent forward flow,” J Surg Res. 2000 Mar;89(1):43–52.
Rydberg, A., Teien, D. E., and Krus, P., 1997, “Computer simulation in patient with total cavo-pulmonary connection: inter-relationship of cardiac and vascular pressure,” flow, resistence and capacitance, Med. Biol. Eng. Comput., Vol. 35, pp. 722–728.
Heldt T, Shim EB, Kamm RD, Mark RG., “Computational modeling of cardiovascular response to orthostatic stress,” J Appl Physiol 2002 Mar;92(3):1239–54
Bull, C., de Leval M. R., and Stark, J., 1983, “Use of a subpulmonary ventricular chamber in the Fontan circulation,” J. Thorac. Cardiovas. Surg., Vol. 85, pp. 21.
Kelley, J. R., Mack, G. W., and Fahey, J. T., 1995, “Diminished venous vascular capacitance in patients with univentricular hearts after the Fontan operations,” American Journal of Cardiology, Vol. 76, pp. 158–163.
Shachar, G. B., et al., 1982, “Rest and exercise hemodynamics after the Fontan procedure,” Circulation, Vol. 65, pp. 1043–1048.
DeBoer, R. W., 1987, “Hemodynamic fluctuations and baroreflex sensitivity in humans: A beat-to-beat model,” American Journal of Physiology, Vol. 253(22), pp. H680–H689.
Kumada, M., Schmidt, K., Sagawa, K., and Tan, K. S., 1970, “ Carotid sinus reflex in response to hemorrhage,” Amer. J. Physiol., 243, H499–H504.
Ursino, M. and Innocenti, M, 1997, “Modeling arterial hypotension during hemodialysis,” Artificial Organs, Vol. 21, 873–890.
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© 2002 Springer-Verlag Berlin Heidelberg
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Bo Shim, E., Hyun Youn, C., Heldt, T., Kamm, R.D., Mark, R.G. (2002). Computational Modeling of the Cardiovascular System After Fontan Procedure. In: Colosimo, A., Sirabella, P., Giuliani, A. (eds) Medical Data Analysis. ISMDA 2002. Lecture Notes in Computer Science, vol 2526. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-36104-9_12
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DOI: https://doi.org/10.1007/3-540-36104-9_12
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