Abstract
A suitable mathematical framework for modeling and simulation will be beneficial for a better and deeper understanding of complex biological systems. Our work shows that a general framework of the mathematical theory of modeling and simulation, together with the network client-server model can lead to a novel software approach and give new insights in molecular networks. Based on the Discrete Event System formalism, in this paper we present a model of the molecular network during T cell activation and other cell responses. The approach is systemic; we do not investigate individual molecules, but describe their network behaviour. The dynamics of molecular networks is provided by a set of interactive processes and appropriate rules for various transition or communication steps. We prove that such a system based mainly on communication has the same expressive power as a Turing machine.
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© 2003 Springer-Verlag Berlin Heidelberg
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Ciobanu, G., Huzum, D. (2003). Discrete Event Systems and Client-Server Model for Signaling Mechanisms. In: Priami, C. (eds) Computational Methods in Systems Biology. CMSB 2003. Lecture Notes in Computer Science, vol 2602. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-36481-1_24
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DOI: https://doi.org/10.1007/3-540-36481-1_24
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Online ISBN: 978-3-540-36481-8
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