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Heterogeneous Sinoatrial Node of Rabbit Heart - Molecular and Electrical Mapping and Biophysical Reconstruction

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Functional Imaging and Modeling of the Heart (FIMH 2003)

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Abstract

Electrophysiology and immunocytochemistry have been used to map the detailed properties of cells cross the pacemaker of the heart, the sinoatrial node. The electrical activities and expressions of various proteins across the sinoatrial node change smoothly with distance and so can be modelled by a gradient in parameter values. Experimental data have been integrated into computational models of the SA node at cellular and tissue levels and mechanisms underlying initiation and propagation of pacemaker activity of the heart identified.

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Author information

Authors and Affiliations

  1. Biological Physics Group, Physics Department, UMIST, Manchester, M60 1QD, UK

    Henggui Zhang

  2. School of Biomedical Sciences, The University of Leeds, LS2 9JT, UK

    Halina Dobrzynski, Arun V. Holden & Mark R. Boyett

Authors
  1. Henggui Zhang
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  2. Halina Dobrzynski
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  3. Arun V. Holden
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  4. Mark R. Boyett
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Editor information

Editors and Affiliations

  1. CREATIS, INSERM, France

    Isabelle E. Magnin

  2. CREATIS, CNRS, INSA, bâatiment Blaise Pascal, 20, avenue Albert Einstein, 69621, Villeurbanne cedex, France

    Johan Montagnat  & Patrick Clarysse  & 

  3. Institute of Biomedical Engineering, Helsinki University of Technology, P.O. Box 2200, 02015, Hut, Finland

    Jukka Nenonen  & Toivo Katila  & 

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© 2003 Springer-Verlag Berlin Heidelberg

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Zhang, H., Dobrzynski, H., Holden, A.V., Boyett, M.R. (2003). Heterogeneous Sinoatrial Node of Rabbit Heart - Molecular and Electrical Mapping and Biophysical Reconstruction. In: Magnin, I.E., Montagnat, J., Clarysse, P., Nenonen, J., Katila, T. (eds) Functional Imaging and Modeling of the Heart. FIMH 2003. Lecture Notes in Computer Science, vol 2674. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-44883-7_14

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  • DOI: https://doi.org/10.1007/3-540-44883-7_14

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-40262-6

  • Online ISBN: 978-3-540-44883-9

  • eBook Packages: Springer Book Archive

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