Abstract
While clinical trials offer cancer patients the optimum treatment approach, historical accrual of such patients has not been very successful. OncoDoc is a decision support system designed to provide best therapeutic recommendations for breast cancer patients. Developed as a browsing tool of a knowledge base structured as a decision tree, OncoDoc allows physicians to monitor the contextual instanciation of patient characteristics to build the best formal equivalent of an actual patient. Used as a computer-based eligibility screening system, depending on whether instanciated patient parameters are matched against guideline knowledge or available clinical trial protocols, it provides either evidence-based therapeutic options or relevant patient-specific clinical trials. Implemented at the Institut Gustave Roussy and routinely used at the point of care, it enhanced physician awareness of open trials and increased of 17% patient enrollment onto clinical trials. However, the analysis of the reasons for non-accrual of potentially eligible patients showed that physicians’ psychological reluctance to refer patients to clinical trials, measured during the experiment at 25%, may not be resolved by the simple dissemination of personnalized clinical trial information.
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© 2001 Springer-Verlag Berlin Heidelberg
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Séroussi, B., Bouaud, J., Antoine, EC., Zelek, L., Spielmann, M. (2001). Using ONCODOC as a Computer-Based Eligibility Screening System to Improve Accrual onto Breast Cancer Clinical Trials. In: Quaglini, S., Barahona, P., Andreassen, S. (eds) Artificial Intelligence in Medicine. AIME 2001. Lecture Notes in Computer Science(), vol 2101. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-48229-6_58
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DOI: https://doi.org/10.1007/3-540-48229-6_58
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