Abstract
The pancreatic β-cell produces the hormone insulin in response to the blood glucose levels. This system is damaged in the diabetes. The central region of the ß-cell electrical response is oscillatory. In this study, we demonstrate that in this region of the response, the membrane resistance of the cells oscillates in phase with the membrane potential. As the cells input resistance reflects the balance of the ionic conductances, we hypothesize that an optimal range of the input resistance determines the capability of the cells to get into oscillations. Under this scope, we propose an electronic circuit able to reproduce the behavior of the biological system. This circuit would be useful to build an artificial insulin pump able to reproduce the physiological pattern.
This is a preview of subscription content, log in via an institution.
Preview
Unable to display preview. Download preview PDF.
References
Dean, P.M. and Matthews, E.K. (1968) Nature 219, 389–390.
Santos, R.M.; Rosario, L.M.: Nadal, A.; Garcia Sancho, J.; Soria, B. and Valdeolmillos, M. (1991) Pflugers Arch. (Eur. J. Physiol) 418, 417–22.
Wollheim, C.B. and Pralong, W.F. (1990) Biochem. Soc. Trans. 18, 111–4.
Rorsman, P., Abrahamsson, H., Gylfe, E. and Hellman, B. (1984) FEBS Lett. 170, 196–220.
Soria, B., Martin, F. and Sanchez-Andres, J.V. (1994). In: Frontiers in β-CETTRESEARCH (Flatt, P. and Lenzen, S. eds) Smith-Gordon, London.
Sanchez-Andres, J.V. and Soria, B. (1983) Lect. Notes Comp. Sci. 686, 37–42
Sanchez-Andrés, J.V.; Ripoll, C. and Soria, B. (1988) FEBS Lett. 231, 143–7.
Reace, E. Teoría y práctica de los osciladores, Ed. Técnicas REDE, 1989, pp. 151–166.
Kahn, S.E. and Porte Jr. D. In: Diabetes Melittas, Rifkin and Porte eds., 4∘. ed, Elsevier, NY, 1990 pp 436–56.
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 1995 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Andreu, E., Soria, B., Bolea, S., Sánchez-Andrés, J.V. (1995). Optimal range of input resistance in the oscillatory behavior of the pancreatic β-cell. In: Mira, J., Sandoval, F. (eds) From Natural to Artificial Neural Computation. IWANN 1995. Lecture Notes in Computer Science, vol 930. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-59497-3_160
Download citation
DOI: https://doi.org/10.1007/3-540-59497-3_160
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-59497-0
Online ISBN: 978-3-540-49288-7
eBook Packages: Springer Book Archive