Abstract
The automation of protocol-based care requires reasoning about a patient's situation over time and about how the standard protocol plan can be adapted to address the patient's current clinical situation. The EON architecture brings together (1) a skeletal-planning reasoning method, ESPR, that can determine appropriate clinical interventions by instantiating an abstract protocol specification, (2) a temporal-reasoning system, RÉSUMÉ, that can infer from time-stamped patient data higher-level, interval-based concepts, and (3) a historical database system, Chronus, that can perform temporal queries on a database of interval-based patient descriptions. The modular problem-solving elements of EON operate on knowledge bases of clinical protocols that clinicians enter into domain-specific knowledge-acquisition tools generated by the PROTÉGÉ-II system. The EON architecture provides an integrated framework for development, execution, and maintenance of clinical-protocol knowledge bases.
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References
Chandrasekaran, B. (1990). Design problem solving: A task analysis. AI Magazine 11(4):59–71.
Clancey, W.J. (1983). The epistemology of a rule-based expert system: A framework for explanation. Artificial Intelligence 20:215–251.
Das, A.K. and Musen, M. A. (1994). A temporal query system for protocol-directed decision support. Methods of Information in Medicine, 33:358–370.
Eriksson, H., Puerta, A.R., and Musen, M.A. (1994). Generation of knowledge-acquisition tools from domain ontologies. International Journal of Human-Computer Studies, 41:425–453.
Eriksson, H., Shahar, Y., Puerta, A.R., Tu, S.W., and Musen, M.A. (in press). Task modeling with reusable problem-solving methods. Artificial Intelligence.
Gennari, J.H., Tu, S.W., Rothenfluh, T.E., and Musen, M.A. (1994). Mapping domains to methods in support of reuse. Internaitonal Journal of Human-Computer Studies, 41:399–424.
Heckerman, D. and Horvitz, E. (1988). The myth of modularity in rule-based systems for reasoning with uncertainty. In Lemmer, J.F. and Kanal, L.N., eds. Uncertainty in Artificial Intelligence 2, pp. 23–34. Amsterdam: North-Holland, 1988.
Hripcsak, G., Ludemann, P., Pryor, T.A., Wigertz, O.B., and Clayton, P.D. (1994). Rationale for the Arden syntax. Computers and Biomedical Research 27:291–324.
Kuilboer, M.M., Shahar, Y., Wilson, D.M., and Musen, M.A. (1993). Knowledge reuse: Temporal-abstraction mechanisms for the assessment of children's growth. Proceedings of the Seventeenth Annual Symposium on Computer Applications in Medicine, pp. 449–453. Washington, D.C.
Lomas, J., Anderson, G.M., Domnick-Pierre, K., et al. (1989). Do practice guidelines guide practice? The effect of a consensus statement on the practice of physicians. New England Journal of Medicine 321:1306–1311.
Marques, D., Dallemagne, G., Klinker, G., McDermott, J., and Tung, D. (1992). Easy programming: empowering people to build their own applications. IEEE Expert 7:16–29.
Musen, M.A. (1992). Dimensions of knowledge sharing and reuse. Computers and Biomedical Research 25:435–467.
Musen, M.A., Carlson, C.W., Fagan, L.M., Deresinski, S.C., and Shortliffe, E.H. (1992a). T-HELPER: Automated support for community-based clinical research. Proceedings of the Sixteenth Annual Symposium on Computer Applications in Medical Care, pp. 719–723. Baltimore, MD.
Musen, M.A., Tu, S.W., and Shahar, Y. (1992b). A problem-solving model for protocol-based care: From e-ONCOCIN to EON. In Proceedings of MEDINFO '92, Seventh World Congress on Medical Informatics, pp. 519–525. Amsterdam: North-Holland.
Musen, M.A., Gennari, J.H., Eriksson, H., Tu, S.W., Puerta, A. R. (1995). PROTÉGÉ-II: Computer Support For Development Of Intelligent Systems From Libraries of Components. Proceedings of MEDINFO '95, Eighth World Congress on Medical Informatics, Vancouver, BC.
Musen, M.A. and Schreiber, A.T. (in press). Architectures for intelligent systems based on reusable components. Artifical Intelligence in Medicine.
Shahar, Y., Das, A.K., Tu, S.W., Kraemer, F.B, and Musen, M.A. (1994). Knowledge-based temporal abstraction for diabetic monitoring. Proceedings of the Eighteenth Annual Symposium on Computer Applications in Medical Care, pp. 697–701. Washington, D.C.
Shahar, Y. and Musen, M.A. (1993). RÉSUMÉ: A temporal-abstraction system for patient monitoring. Computers and Biomedical Research 26:255–273.
Shahar, Y. (1994). A knowledge-based method for temporal abstraction of clinical data. Ph.D. Dissertation, Program in Medical Information Sciences, Stanford University, Computer Science Dpartment Technical Report STAN-CS-TR-94-1529.
Shwe, M., Sujansky, W., and Middleton, B. (1992). Reuse of knowledge represented in the Arden syntax. Proceedings of the Sixteenth Annual Symposium on Computer Applications in Medical Care, pp. 47–51. Baltimore, MD.
Tu, S.W., Kahn, M.G., Musen, M.A., Ferguson, J.C., Shortliffe, E.H., and Fagan, L.M. (1989). Episodic skeletal-plan refinement on temporal data. Communications of the ACM 32:1439–1455.
Tu, S.W., Kemper, C.A., Lane, N.M., Carlson, R.W., and Musen, M.A. (1993). A methodology for determining patients' eligibility for clinical trials. Methods of Information in Medicine 32:317–325.
Tu, S.W., Eriksson, H., Gennari, J., Shahar, Y., Musen, M.A. (in press). Ontology-based configuration of problem-solving methods and generation of knowledge-acquisition tools: Application of PROTÉGÉ-II to protocol-based decision support. Artificial Intelligence in Medicine.
van der Lei, J. and Musen, M.A. (1991). A model for critiquing based on automated medical records. Computers and Biomedical Research 24:344–378.
van Heijst, G., Schreiber, G., Lanzola, G. and Stefanelli, M. (1994). Foundations for a methodology for medical KBS development. Knowledge Acquisition 6:395–434.
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Musen, M.A., Tu, S.W., Das, A.K., Shahar, Y. (1995). A component-based architecture for automation of protocol-directed therapy. In: Barahona, P., Stefanelli, M., Wyatt, J. (eds) Artificial Intelligence in Medicine. AIME 1995. Lecture Notes in Computer Science, vol 934. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-60025-6_121
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DOI: https://doi.org/10.1007/3-540-60025-6_121
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