Abstract
The aim of our study is to investigate the mechanism of tolerance induction by the modulatory anti CD4 monoclonal antibody RIB 5/2 in insulin dependent diabetes mellitus rats. By this approach it should be possible to identify the key mechanisms of immune tolerance on the level of T cell, cytokine, and chemokine biomarkers in blood, lymphatic organs, and pancreas; and furthermore to define biomarkers of autoimmunity and tolerance fpr prediction of diabetes onset. So far, decision trees and some other classification algorithms have been applied on data sets of twelve rats.
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© 2011 Springer-Verlag London Limited
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Schmidt, R., Weiss, H., Fuellen, G. (2011). Analysis of IDDM Rats. In: Bramer, M., Petridis, M., Nolle, L. (eds) Research and Development in Intelligent Systems XXVIII. SGAI 2011. Springer, London. https://doi.org/10.1007/978-1-4471-2318-7_29
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DOI: https://doi.org/10.1007/978-1-4471-2318-7_29
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