Definition
Postinhibitory rebound (PIR) and postinhibitory facilitation (PIF) are both phenomena that modify the intrinsic excitability of a neuron or a network resulting in an enhanced or patterned spike output. In a single neuron, the PIR represents evoking one or more spikes in response to the cessation of a prolonged hyperpolarizing current step. However, the response can also occur for a hyperpolarizing stimulus that is temporally brief. The PIF in a single neuron represents the phenomenon of evoking a spike when a late arriving subthreshold excitatory input is assisted by an early inhibitory input. The inhibitory input causes a reduction of spike threshold at the time of arrival of the subthreshold excitation.
Detailed Description
Rebound is a somewhat generic term that indicates the overshoot of a membrane potential above its resting level, and not necessarily a spike. The excitable property of an inhibitory stimulus applied to a neuron was identified more than a century ago by...
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Dodla, R. (2014). Postinhibitory Rebound and Facilitation. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_152-1
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DOI: https://doi.org/10.1007/978-1-4614-7320-6_152-1
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