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Calmodulin, Models of

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References

  • Bayley PM, Findlay WA et al (1996) Target recognition by calmodulin: dissecting the kinetics and affinity of interaction using short peptide sequences. Protein Sci 5(7):1215–1228

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Bhattacharya S, Bunick CG et al (2004) Target selectivity in EF-hand calcium binding proteins. Biochim Biophys Acta 1742:69–79

    Article  CAS  PubMed  Google Scholar 

  • Choi J, Husain M (2006) Calmodulin-mediated cell cycle regulation: new mechanisms for old observations. Cell Cycle 5(19):2183–2186

    Article  CAS  PubMed  Google Scholar 

  • Crivici A, Ikura M (1995) Molecular and structural basis of target recognition by calmodulin. Annu Rev Biophys Biomol Struct 24:85–116

    Article  CAS  PubMed  Google Scholar 

  • Debye P, Hückel E (1923) The theory of electrolytes. I. Lowering of freezing point and related phenomena. Physikalische Zeitschrift 24:185–206

    CAS  Google Scholar 

  • Faas GC, Raghavachari S et al (2011) Calmodulin as a direct detector of Ca2+ signals. Nat Neurosci 14(3):301–304

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Gaertner TR, Putkey JA et al (2004) RC3/Neurogranin and Ca2+/calmodulin-dependent protein kinase II produce opposing effects on the affinity of calmodulin for calcium. J Biol Chem 279(38):39374–39382

    Article  CAS  PubMed  Google Scholar 

  • Hoeflich KP, Ikura M (2002) Calmodulin in action: diversity in target recognition and activation mechanisms. Cell 108:739–742

    Article  CAS  PubMed  Google Scholar 

  • Holmes WR (2000) Models of calmodulin trapping and CaM kinase II activation in a dendritic spine. J Comput Neurosci 8(1):65–85

    Article  CAS  PubMed  Google Scholar 

  • Homouz D, Sanabria H et al (2009) Modulation of calmodulin plasticity by the effect of macromolecular crowding. J Mol Biol 391:933–943

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Keller DX, Franks KM et al (2008) Calmodulin activation by calcium transients in the postsynaptic density of dendritic spines. PLoS One 3(4):e2045

    Article  PubMed Central  PubMed  Google Scholar 

  • Kubota Y, Waxham MN (2010) Lobe specific Ca2+−calmodulin nano-domain in neuronal spines: a single molecule level analysis. PLoS Comput Biol 6(11):e1000987

    Article  PubMed Central  PubMed  Google Scholar 

  • Linse S, Helmersson A et al (1991) Calcium binding to calmodulin and its globular domains. J Biol Chem 266(13):8050–8054

    CAS  PubMed  Google Scholar 

  • Minton A (1981) Excluded volume as a determinant of macromolecular structure and reactivity. Biopolymers 20:2093–2120

    Article  CAS  Google Scholar 

  • Price ES, DeVore MS et al (2010) Detecting intramolecular dynamics and multiple forster resonance energy transfer states by fluorescence correlation spectroscopy. J Phys Chem B 114:5895–5902

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Putkey JA, Waxham MN et al (2008) Acidic/IQ motif regulator of calmodulin. J Biol Chem 283(3):1401–1410

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Saucerman JJ, Bers DM (2008) Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes. Biophys J 95(10):4597–4612

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Shaw DE, Maragakis P et al (2010) Atomic-level characterization of the structural dynamics of proteins. Science 330:341–346

    Article  CAS  PubMed  Google Scholar 

  • Slaughter BD, Bieber-Urbauer RJ et al (2005) Single-molecule tracking of sub-millisecond domain motion in calmodulin. J Phys Chem B 109:12658–12662

    Article  CAS  PubMed  Google Scholar 

  • Stefan MI, Edelstein SJ et al (2008) An allosteric model of calmodulin explains differential activation of PP2B and CaMKII. Proc Natl Acad Sci U S A 105(31):10768–10773

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Wang Q, Liang KC et al (2011) The effect of macromolecular crowding, ionic strength and calcium binding on calmodulin dynamics. Plos Comput Biol 7(7)

    Google Scholar 

  • Yamniuk AP, Vogel HJ (2004) Calmodulin’s flexibility allows for promiscuity in its interaction with target proteins and peptides. Mol Biotechnol 27:33–57

    Article  CAS  PubMed  Google Scholar 

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Correspondence to M. Neal Waxham .

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Waxham, M.N., Cheung, M.S. (2013). Calmodulin, Models of. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_183-1

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_183-1

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