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Encyclopedia of Computational Neuroscience pp 1–5Cite as

Striatal Models, Cellular Detail

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Definition

Models of neuron types of the striatum, which include details of ion channels and neuron morphology.

Detailed Description

Striatal Function in Disease and Health

The striatum is the main input structure of the basal ganglia and is implicated in habit learning, addiction, and neuropathologies such as Parkinson’s disease and Huntington’s disease. Parkinson’s disease is a motor dysfunction caused by degeneration of dopaminergic neurons that project strongly to the striatum. Huntington’s disease is another motor dysfunction caused by degeneration of a subset of the neurons in the striatum. Experiments in both humans and animals have demonstrated that normal habit learning involves the striatum, and changes in striatal neural activity are observed consequent to cortical glutamatergic activity (in response to environmental stimuli or motor activity) and dopamine release in response to reward.

Cell Classes in the Striatum

The projection neurons of the striatum are the medium spiny...

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References

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Author information

Authors and Affiliations

  1. Molecular Neuroscience Department, Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA, USA

    Kim T. Blackwell

  2. Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA, USA

    Sriraman Damodaran & Rebekah Evans

Authors
  1. Kim T. Blackwell
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  2. Sriraman Damodaran
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  3. Rebekah Evans
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Corresponding author

Correspondence to Kim T. Blackwell .

Editor information

Editors and Affiliations

  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

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© 2014 Springer Science+Business Media New York

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Blackwell, K.T., Damodaran, S., Evans, R. (2014). Striatal Models, Cellular Detail. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_88-1

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_88-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7320-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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Chapter history

  1. Latest

    Basal Ganglia: Striatal Models Cellular Detail
    Published:
    07 October 2019

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_88-2

  2. Original

    Striatal Models, Cellular Detail
    Published:
    13 March 2014

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_88-1

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