Skip to main content

A Pathology Image Diagnosis Network with Visual Interpretability and Structured Diagnostic Report

  • Conference paper
  • First Online:
Neural Information Processing (ICONIP 2018)

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 11306))

Included in the following conference series:

Abstract

Despite recent advances in medical diagnosis domain, many challenges remain in obtaining more accurate conclusions and in presenting semantically and visually interpretable results during the diagnosis process. An interpretable diagnosis process is proposed through the implementation of a deep learning model. This consists of three interrelated models, an image model, an attention model and a conclusion model. The proposed image model extracts the semantic feature using convolutional neural networks (CNNs). The conclusion model, integrated with the semantic attributes attention model, aims to predict the conclusion label by long-short term memory (LSTM), which captures the discriminative relationship between semantic attributes. The network is trained in end-to-end way with different weight of each model. Based upon a cervical intraepithelial neoplasia images, diagnostic report and labels (CINDRAL) dataset, the approach demonstrates significant improvement when comparing the baseline in the conclusion result.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Zhang, X., Su, H., Yang, L., Zhang, S.: Fine-grained histopathological image analysis via robust segmentation and large-scale retrieval. In: Computer Vision and Pattern Recognition, pp. 5361–5368 (2015)

    Google Scholar 

  2. Chang, H., Zhou, Y., Borowsky, A., Barner, K., Spellman, P., Parvin, B.: Stacked predictive sparse decomposition for classification of histology sections. Int. J. Comput. Vis. 113(1), 3–18 (2015)

    Article  MathSciNet  Google Scholar 

  3. Cireşan, D.C., Giusti, A., Gambardella, L.M., Schmidhuber, J.: Mitosis detection in breast cancer histology images with deep neural networks. In: Mori, K., Sakuma, I., Sato, Y., Barillot, C., Navab, N. (eds.) MICCAI 2013. LNCS, vol. 8150, pp. 411–418. Springer, Heidelberg (2013). https://doi.org/10.1007/978-3-642-40763-5_51

    Chapter  Google Scholar 

  4. Russakovsky, O., et al.: Imagenet large scale visual recognition challenge. Int. J. Comput. Vis. 115(3), 211–252 (2014)

    Article  MathSciNet  Google Scholar 

  5. Kisilev, P., Walach, E., Hashoul, S., Barkan, E., Ophir, B., Alpert, S.: Semantic description of medical image findings: structured learning approach. In: British Machine Vision Conference, pp. 171.1–171.11 (2015)

    Google Scholar 

  6. Esteva, A., et al.: Corrigendum: dermatologist-level classification of skin cancer with deep neural networks. Nature 542(7639), 115–118 (2017)

    Article  Google Scholar 

  7. Chartrand, G., et al.: Deep learning: a primer for radiologists. Radiographics 37(7), 2113–2131 (2017)

    Article  Google Scholar 

  8. Zhang, Z., Chen, P., Sapkota, M., Yang, L.: TandemNet: distilling knowledge from medical images using diagnostic reports as optional semantic references. In: Descoteaux, M., Maier-Hein, L., Franz, A., Jannin, P., Collins, D.L., Duchesne, S. (eds.) MICCAI 2017. LNCS, vol. 10435, pp. 320–328. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-66179-7_37

    Chapter  Google Scholar 

  9. Kisilev, P., Walach, E., Barkan, E., Ophir, B.: From medical image to automatic medical report generation. IBM J. Res. Dev. 59(2/3), 2:1–2:7 (2015)

    Article  Google Scholar 

  10. Jing, B., Xie, P., Xing, E.: On the automatic generation of medical imaging reports (2017). arXiv:1711.08195

  11. Surhone, L.M., Tennoe, M.T., Henssonow, S.F.: Long Short Term Memory. Beta Script Publishing (2010)

    Google Scholar 

  12. Zhang, Z., Xie, Y., Xing, F., Mcgough, M., Yang, L.: Mdnet: a semantically and visually interpretable medical image diagnosis network, pp. 3549–3557 (2017)

    Google Scholar 

  13. Wang, Z., Chen, T., Li, G., Xu, R., Lin, L.: Multi-label image recognition by recurrently discovering attentional regions. In: IEEE International Conference on Computer Vision, pp. 464–472 (2017)

    Google Scholar 

  14. Shi, X., Xing, F., Xie, Y., Su, H., Yang, L.: Cell encoding for histopathology image classification. In: Descoteaux, M., Maier-Hein, L., Franz, A., Jannin, P., Collins, D.L., Duchesne, S. (eds.) MICCAI 2017. LNCS, vol. 10434, pp. 30–38. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-66185-8_4

    Chapter  Google Scholar 

  15. Nam, H., Ha, J.W., Kim, J.: Dual attention networks for multimodal reasoning and matching, pp 2156–2164 (2016)

    Google Scholar 

  16. Pedersoli, M., Lucas, T., Schmid, C., Verbeek, J.: Areas of attention for image captioning, pp. 1251–1259 (2017)

    Google Scholar 

  17. Vinyals, O., Fortunato, M., Jaitly, N.: Pointer networks. In: Computer Science (2015)

    Google Scholar 

  18. Xu, K., Ba, J., Kiros, R., Cho, K., Courville, A., Salakhutdinov, R., Zemel, R., Bengio, Y.: Show, attend and tell: neural image caption generation with visual attention. In: Computer Science, pp. 2048–2057 (2015)

    Google Scholar 

  19. Yu, D., Fu, J., Mei, T., Rui, Y.: Multi-level attention networks for visual question answering. In: IEEE Conference on Computer Vision and Pattern Recognition, pp. 4187–4195 (2017)

    Google Scholar 

  20. Lu, J., Xiong, C., Parikh, D., Socher, R.: Knowing when to look: adaptive attention via a visual sentinel for image captioning, pp. 3242–3250 (2016)

    Google Scholar 

  21. Shin, H.C., Roberts, K., Lu, L., Demnerfushman, D., Yao, J., Summers, R.M.: Learning to read chest x-rays: recurrent neural cascade model for automated image annotation, pp. 2497–2506 (2016)

    Google Scholar 

  22. Wang, X., Peng, Y., Lu, L., Lu, Z., Summers, R.M.: Tienet: text-image embedding network for common thorax disease classification and reporting in chest x-rays (2018). arXiv:1801.04334

  23. Everingham, M., Winn, J.: The pascal visual object classes challenge 2010 development kit contents. In: International Conference on Machine Learning Challenges: Evaluating Predictive Uncertainty Visual Object Classification, pp. 117–176 (2011)

    Google Scholar 

  24. Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. Computer Science (2014)

    Google Scholar 

  25. Krizhevsky, A., Sutskever, I., Hinton, G.E.: Imagenet classification with deep convolutional neural networks, pp 1097–1105 (2012)

    Google Scholar 

  26. Huang, G., Liu, Z., Maaten, L.V.D., Weinberger, K.Q.: Densely connected convolutional networks. In: CVPR (2017)

    Google Scholar 

  27. Zhou, B., Khosla, A., Lapedriza, A., Oliva, A., Torralba, A.: Learning deep features for discriminative localization. In: IEEE Conference on Computer Vision and Pattern Recognition, pp. 2921–2929 (2016)

    Google Scholar 

  28. He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition, pp. 770–778 (2015)

    Google Scholar 

  29. Wang, J., Yang, Y., Mao, J., Huang, Z., Huang, C., Xu, W.: Cnn-rnn: a unified framework for multi-label image classification, pp. 2285–2294 (2016)

    Google Scholar 

  30. Lin, T.-Y., et al.: Microsoft COCO: common objects in context. In: Fleet, D., Pajdla, T., Schiele, B., Tuytelaars, T. (eds.) ECCV 2014. LNCS, vol. 8693, pp. 740–755. Springer, Cham (2014). https://doi.org/10.1007/978-3-319-10602-1_48

    Chapter  Google Scholar 

Download references

Acknowledgements

This work is supported by the National Key Scientific Instruments and Equipment Development Program of China (2013YQ03065101), the National Natural Science Foundation of China under Grant 61521063 and Grant 61503243.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kaijie Wu .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Ma, K., Wu, K., Cheng, H., Gu, C., Xu, R., Guan, X. (2018). A Pathology Image Diagnosis Network with Visual Interpretability and Structured Diagnostic Report. In: Cheng, L., Leung, A., Ozawa, S. (eds) Neural Information Processing. ICONIP 2018. Lecture Notes in Computer Science(), vol 11306. Springer, Cham. https://doi.org/10.1007/978-3-030-04224-0_24

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-04224-0_24

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-04223-3

  • Online ISBN: 978-3-030-04224-0

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics