Abstract
Cardiovascular magnetic resonance imaging (CMR) is frequently used for patients with suspected hypertrophic cardiomyopathy (HCM). However, although magnetization-tagged MRI can provide quantitative assessment of regional function in HCM, it is not routinely used in clinical CMR of HCM. Therefore, we investigated the added value of acquiring a single three-chamber (3Ch) tagged cine image sequence to our clinical HCM protocol. Forty-eight patients with HCM, five patients with “septal knuckle” (SK), and 20 healthy volunteers underwent CMR at 1.5T, including a 3Ch tagged cine sequence. The images were analyzed for regional deformation (strain) and myocardial wall thickness, and results were compared to data from healthy volunteers. In HCM, we found a reduced tangential strain (p < 0.003) with decreased relaxation in hypertrophied segments, and mildly reduced strain (p < 0.035) with decreased relaxation in segments without hypertrophy. There was an inverse correlation between principal strain magnitude and local septal wall thickness (p < 0.001). Patients with SK had a higher tangential strain in the basal septum compared to patients with asymmetrical septal hypertrophy due to HCM, which may aid in differentiating focal HCM from SK. Thus, adding a 3Ch tagged MRI sequence to clinical CMR examinations of suspected HCM patients can provide functional information, aiding in differentiating SK from HCM, with minimal additional time cost.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Gersh, B.J., et al.: 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Developed in collaboration with the American Association for Thoracic Surgery, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J. Am. Coll. Cardiol. 58, e212–e260 (2011)
Maron, M.S., et al.: Hypertrophic cardiomyopathy is predominantly a disease of left ventricular outflow tract obstruction. Circulation 114, 2232–2239 (2006)
Maron, M.S., et al.: Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy. New Engl. J. Med. 348, 295–303 (2003)
Sherrid, M.V., Pearle, G., Gunsburg, D.Z.: Mechanism of benefit of negative inotropes in obstructive hypertrophic cardiomyopathy. Circulation 97, 41–47 (1998)
Ionita, C.N., et al.: Challenges and limitations of patient-specific vascular phantom fabrication using 3D Polyjet printing. In: Proceedings of SPIE–The International Society for Optical Engineering, vol. 9038, p. 90380 M (2014)
Sherrid, M.V., Balaram, S., Kim, B., Axel, L., Swistel, D.G.: The mitral valve in obstructive hypertrophic cardiomyopathy a test in context. J. Am. Coll. Cardiol. 67, 1846–1858 (2016)
Axel, L., Dougherty, L.: MR imaging of motion with spatial modulation of magnetization. Radiology 171, 841–845 (1989)
Tautz, L., Hennemuth, A., Peitgen, H.-O.: Motion analysis with quadrature filter based registration of tagged MRI sequences. In: Camara, O., Konukoglu, E., Pop, M., Rhode, K., Sermesant, M., Young, A. (eds.) STACOM 2011. LNCS, vol. 7085, pp. 78–87. Springer, Heidelberg (2012). https://doi.org/10.1007/978-3-642-28326-0_8
Ritter, F., et al.: Medical image analysis. IEEE Pulse 2, 60–70 (2011)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this paper
Cite this paper
Kanski, M. et al. (2019). Analysis of Three-Chamber View Tagged Cine MRI in Patients with Suspected Hypertrophic Cardiomyopathy. In: Coudière, Y., Ozenne, V., Vigmond, E., Zemzemi, N. (eds) Functional Imaging and Modeling of the Heart. FIMH 2019. Lecture Notes in Computer Science(), vol 11504. Springer, Cham. https://doi.org/10.1007/978-3-030-21949-9_46
Download citation
DOI: https://doi.org/10.1007/978-3-030-21949-9_46
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-21948-2
Online ISBN: 978-3-030-21949-9
eBook Packages: Computer ScienceComputer Science (R0)