Abstract
Functional near infrared spectroscopy (fNIRS), an emerging, versatile, and non-invasive functional neuroimaging technique, promises to yield new neuroscientific insights, and tools for brain-computer-interface applications and diagnostics. In this work, we consider the novel problem of detecting cannabis intoxication based on resting-state fNIRS data. We examine several machine learning approaches and present an innovative data augmentation technique suitable for resting-state functional data. Our experiments suggest that a recurrent neural network model trained on dynamic functional connectivity matrices, computed on sliding windows, coupled with the proposed data augmentation strategy yields the best accuracy for our application. We achieve up to 90\(\%\) area under the ROC on cross-validation for detecting cannabis associated intoxication at the individual-level. We also report an independent validation of the best performing model on data not used in cross-validation.
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References
Sewell, R., Poling, J., Sofuoglu, M.: The effect of cannabis compared with alcohol on driving. Am. J. Addict. 18, 185–193 (2009)
Keles, H., Radoman, M., Pachas, G., Evins, A., Gilman, J.: Using functional near-infrared spectroscopy to measure effects of delta 9-tetrahydrocannabinol on prefrontal activity and working memory in cannabis users. Front. Hum. Neurosci. 11, 488–498 (2017)
McIntosh, M., Shahani, U., Boulton, R., McCulloch, D.: Absolute quantification of oxygenated hemoglobin within the visual cortex with functional near infrared spectroscopy (fNIRS). Invest. Ophthalmol. Vis. Sci. 51(9), 4856–4860 (2010)
Quaresima, V., Ferrari, M.: Functional near-infrared spectroscopy (fNIRS) for assessing cerebral cortex function during human behavior in natural/social situations: a concise review. Organ. Res. Methods 22(1), 46–68 (2019)
Wee, C., Yap, P., Shen, D.: Diagnosis of autism spectrum disorders using temporally distinct resting-state functional connectivity networks. CNS Neurosci. Ther. 22, 212–219 (2016)
Eavani, H., Satterthwaite, T.D., Gur, R.E., Gur, R.C., Davatzikos, C.: Unsupervised learning of functional network dynamics in resting state fMRI. In: Gee, J.C., Joshi, S., Pohl, K.M., Wells, W.M., Zöllei, L. (eds.) IPMI 2013. LNCS, vol. 7917, pp. 426–437. Springer, Heidelberg (2013). https://doi.org/10.1007/978-3-642-38868-2_36
Wee, C., Yap, P., Zhang, D., Wang, L., Shen, D.: Group-constrained sparse fMRI connectivity modeling for mild cognitive impairment identification. Brain Struct. Funct. 219, 641–656 (2014)
Lv, J., Jiang, X., Li, X., Zhu, D., Chen, H., Zhang, T.: Sparse representation of whole-brain fMRI signals for identification of functional networks. Med. Image Anal. 20, 112–134 (2015)
Kiviniemi, V., et al.: A sliding time-window ICA reveals spatial variability of the default mode network in time. Brain connectivity 1(4), 339–347 (2011)
Chang, C., Glover, G.H.: Time-frequency dynamics of resting-state brain connectivity measured with fMRI. NeuroImage 50, 81–98 (2010)
Di, X., Biswal, B.: Dynamic brain functional connectivity modulated by resting-state networks. Brain Struct. Funct. 220, 37–46 (2015)
Leonardi, N.: Principal components of functional connectivity: a new approach to study dynamic brain connectivity during rest. NeuroImage 83, 937–950 (2013)
Khosla, M., Jamison, K., Ngo, G.H., Kuceyeski, A., Sabuncu, M.R.: Machine learning in resting-state fMRI analysis. Magn. Reson. Imaging (2019)
Leonardi, N., Ville, D.V.D.: On spurious and real fluctuations of dynamic functional connectivity during rest. Neuroimage 104, 430–436 (2015)
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Zhu, Y., Gilman, J., Evins, A.E., Sabuncu, M. (2019). Detecting Cannabis-Associated Cognitive Impairment Using Resting-State fNIRS. In: Shen, D., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2019. MICCAI 2019. Lecture Notes in Computer Science(), vol 11768. Springer, Cham. https://doi.org/10.1007/978-3-030-32254-0_17
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