Abstract
Magnetic Resonance Spectroscopy Imaging (MRSI) is a spectral imaging method that measures per voxel spectral information of chemical resonance, from which metabolite concentrations can be computed. In recent work, we proposed a system that uses coordinated views between image-space visualizations and visual representations of the spectral (or feature) space. Coordinated interaction allowed us to analyze all metabolite concentrations together instead of focusing only at single metabolites at a time [8]. In this paper, we want to relate our findings to different results reported in the literature. MRSI is particularly useful for tumor classification and measuring its infiltration of healthy tissue. We compare the metabolite compositions obtained in the various tissues of our data against the compositions reported by other brain tumor studies using a visual analytics approach. It visualizes the similarities in a plot obtained using dimensionality reduction methods. We test our data against various sources to test the reproducibility of the findings.
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References
Board: PDQ Adult Treatment Editorial: Adult central nervous system tumors treatment PDQ®. In: PDQ Cancer Information Summaries. National Cancer Institute (US) (2018)
Burnet, N.G., Thomas, S.J., Burton, K.E., Jefferies, S.J.: Defining the tumour and target volumes for radiotherapy. Cancer Imaging 4(2), 153–161 (2004)
Crane, J.C., Olson, M.P., Nelson, S.J.: SIVIC: open-source, standards-based software for DICOM MR spectroscopy workflows. Int. J. Biomed. Imaging 2013, 1–12 (2013). https://doi.org/10.1155/2013/169526
Feng, D., Kwock, L., Lee, Y., Taylor, R.M.: Linked exploratory visualizations for uncertain MR spectroscopy data. In: Park, J., Hao, M.C., Wong, P.C., Chen, C. (eds.) Visualization and Data Analysis 2010. SPIE, January 2010. https://doi.org/10.1117/12.839818
Gujar, S.K., Maheshwari, S., Björkman-Burtscher, I., Sundgren, P.C.: Magnetic resonance spectroscopy. J. Neuro Ophthalmol. 25(3), 217–226 (2005)
Hoffman, P., Grinstein, G., Marx, K., Grosse, I., Stanley, E.: DNA visual and analytic data mining. In: Proceedings of IEEE Visualization 1997 (Cat. No. 97CB36155), pp. 437–441, October 1997. https://doi.org/10.1109/VISUAL.1997.663916
Howe, F., et al.: Metabolic profiles of human brain tumors using quantitative in vivo \(^1\)H magnetic resonance spectroscopy. Magn. Reson. Med. 49(2), 223–232 (2003). https://doi.org/10.1002/mrm.10367
Jawad., M., Molchanov., V., Linsen., L.: Coordinated image- and feature-space visualization for interactive magnetic resonance spectroscopy imaging data analysis. In: Proceedings of the 14th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications - Volume 3: IVAPP, pp. 118–128. INSTICC, SciTePress (2019). https://doi.org/10.5220/0007571801180128
Johnson, H.J., McCormick, M., Ibáñez, L., Consortium, T.I.S.: The ITK Software Guide, 3rd edn. Kitware Inc. (2013). http://www.itk.org/ItkSoftwareGuide.pdf
Kandogan, E.: Star coordinates: a multi-dimensional visualization technique with uniform treatment of dimensions. In: Proceedings of the IEEE Information Visualization Symposium, Late Breaking Hot Topics, pp. 9–12 (2000)
Kinoshita, Y., Yokota, A.: Absolute concentrations of metabolites in the human brain tumors using in vitro proton magnetic resonance spectroscopy. NMR Biomed. 10(1), 2–12 (1997)
Li, C., Gore, J.C., Davatzikos, C.: Multiplicative Intrinsic Component Optimization (MICO) for MRI bias field estimation and tissue segmentation. Magn. Reson. Imaging 32(7), 913–923 (2014)
Liu, S., Maljovec, D., Wang, B., Bremer, P., Pascucci, V.: Visualizing high-dimensional data: advances in the past decade. IEEE Trans. Vis. Comput. Graph. 23(3), 1249–1268 (2017). https://doi.org/10.1109/TVCG.2016.2640960
Matkovic, K., Freiler, W., Gracanin, D., Hauser, H.: ComVis: a coordinated multiple views system for prototyping new visualization technology. In: 2008 12th International Conference Information Visualisation, pp. 215–220. IEEE (2008)
Maudsley, A., et al.: Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging. NMR Biomed. 19(4), 492–503 (2006)
McKnight, T.R., Noworolski, S.M., Vigneron, D.B., Nelson, S.J.: An automated technique for the quantitative assessment of 3D-MRSI data from patients with glioma. J. Magn. Reson. Imaging Official J. Int. Soc. Magn. Reson. Med. 13(2), 167–177 (2001)
Molchanov, V., Linsen, L.: Interactive design of multidimensional data projection layout. In: Elmqvist, N., Hlawitschka, M., Kennedy, J. (ed.) EuroVis - Short Papers. The Eurographics Association (2014). https://doi.org/10.2312/eurovisshort.20141152
Molchanov, V., Linsen, L.: Shape-preserving star coordinates. IEEE Trans. Visual Comput. Graphics 25(1), 449–458 (2019). https://doi.org/10.1109/TVCG.2018.2865118
Nunes, M., Laruelo, A., Ken, S., Laprie, A., Bühler, K.: A survey on visualizing magnetic resonance spectroscopy data. In: Proceedings of the 4th Eurographics Workshop on Visual Computing for Biology and Medicine, pp. 21–30. Eurographics Association (2014)
Nunes, M., et al.: An integrated visual analysis system for fusing MR spectroscopy and multi-modal radiology imaging. In: 2014 IEEE Conference on Visual Analytics Science and Technology (VAST), pp. 53–62. IEEE (2014)
Pagliosa, L., Telea, A.: Radviz++: improvements on radial-based visualizations. Informatics 6(2), 16–38 (2019). https://doi.org/10.3390/informatics6020016
Peeling, J., Sutherland, G.: High-resolution \(^1\)H NMR spectroscopy studies of extracts of human cerebral neoplasms. Magn. Reson. Med. 24(1), 123–136 (1992). https://doi.org/10.1002/mrm.1910240113
Provencher, S.W.: Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn. Reson. Med. 30(6), 672–679 (1993)
Raschke, F., Jones, T., Barrick, T., Howe, F.: Delineation of gliomas using radial metabolite indexing. NMR Biomed. 27(9), 1053–1062 (2014)
Reynolds, G., Wilson, M., Peet, A., Arvanitis, T.: An algorithm for the automated quantitation of metabolites in in-vitro NMR signals. Magn. Reson. Med. 56(6), 1211–1219 (2006)
Rowland, B., et al.: 30th Annual Scientific Meeting Beyond the Metabolic Map: An Alternative Perspective on MRSI Data, ESMRMB 2013, p. 270 (2013)
Scheenen, T.W., Heerschap, A., Klomp, D.W.: Towards \(^{1}\)H-MRSI of the human brain at 7T with slice-selective adiabatic refocusing pulses. Magn. Reson. Mater. Phys., Biol. Med. 21(1–2), 95–101 (2008)
Schroeder, W., Martin, K., Lorensen, B., Avila, S.L., Avila, R., Law, C.: The Visualization Toolkit, 4th edn. Kitware Inc. (2006). https://www.vtk.org/vtk-textbook/
Stefan, D., et al.: Quantitation of magnetic resonance spectroscopy signals: the jMRUI software package. Meas. Sci. Technol. 20(10), 104035 (2009)
Teoh, S.T., Ma, K.L.: StarClass: interactive visual classification using star coordinates. In: SDM, pp. 178–185. SIAM (2003)
Vanhamme, L., Sundin, T., Hecke, P.V., Huffel, S.V.: MR spectroscopy quantitation: a review of time-domain methods. NMR Biomed. 14(4), 233–246 (2001)
Wilson, M., Reynolds, G., Kauppinen, R.A., Arvanitis, T.N., Peet, A.C.: A constrained least-squares approach to the automated quantitation of in vivo \(^{1}\)H magnetic resonance spectroscopy data. Magn. Reson. Med. 65(1), 1–12 (2011)
Wolf, I., et al.: The medical imaging interaction ToolKit MITK: a toolkit facilitating the creation of interactive software by extending VTK and ITK, vol. 5367, p. 5367 (2004). https://doi.org/10.1117/12.535112
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Jawad, M., Molchanov, V., Linsen, L. (2020). A Reproducibility Study for Visual MRSI Data Analytics. In: Cláudio, A., et al. Computer Vision, Imaging and Computer Graphics Theory and Applications. VISIGRAPP 2019. Communications in Computer and Information Science, vol 1182. Springer, Cham. https://doi.org/10.1007/978-3-030-41590-7_15
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