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Detection and Segmentation of Brain Tumors from MRI Using U-Nets

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Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries (BrainLes 2019)

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Abstract

In this paper, we exploit a cascaded U-Net architecture to perform detection and segmentation of brain tumors (low- and high-grade gliomas) from magnetic resonance scans. First, we detect tumors in a binary-classification setting, and they later undergo multi-class segmentation. The total processing time of a single input volume amounts to around 15  s using a single GPU. The preliminary experiments over the BraTS’19 validation set revealed that our approach delivers high-quality tumor delineation and offers instant segmentation.

We applied the sequence-determines-credit approach for the sequence of authors.

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References

  1. Aljabar, P., Heckemann, R., Hammers, A., Hajnal, J., Rueckert, D.: Multi-atlas based segmentation of brain images: atlas selection and its effect on accuracy. NeuroImage 46(3), 726–738 (2009)

    Article  Google Scholar 

  2. Bakas, S., et al.: Advancing the cancer genome atlas glioma MRI collections with expert segmentation labels and radiomic features. Nat. Sci. Data 4, 1–13 (2017). https://doi.org/10.1038/sdata.2017.117

    Article  Google Scholar 

  3. Bakas, S., et al.: Segmentation labels and radiomic features for the pre-operative scans of the TCGA-GBM collection. Cancer Imaging Arch. (2017). https://doi.org/10.7937/K9/TCIA.2017.KLXWJJ1Q

  4. Bakas, S., et al.: Segmentation labels and radiomic features for the pre-operative scans of the TCGA-LGG collection. Cancer Imaging Arch. (2017). https://doi.org/10.7937/K9/TCIA.2017.GJQ7R0EF

  5. Bakas, S., et al.: Identifying the best machine learning algorithms for brain tumor segmentation, progression assessment, and overall survival prediction in the BRATS challenge (2018). CoRR abs/1811.02629. http://arxiv.org/abs/1811.02629

  6. Bauer, S., Seiler, C., Bardyn, T., Buechler, P., Reyes, M.: Atlas-based segmentation of brain tumor images using a Markov random field-based tumor growth model and non-rigid registration. In: Proceedings of the IEEE EMBC, pp. 4080–4083 (2010). https://doi.org/10.1109/IEMBS.2010.5627302

  7. Chander, A., Chatterjee, A., Siarry, P.: A new social and momentum component adaptive PSO algorithm for image segmentation. Exp. Syst. Appl. 38(5), 4998–5004 (2011)

    Article  Google Scholar 

  8. Fan, X., Yang, J., Zheng, Y., Cheng, L., Zhu, Y.: A novel unsupervised segmentation method for MR brain images based on fuzzy methods. In: Liu, Y., Jiang, T., Zhang, C. (eds.) CVBIA 2005. LNCS, vol. 3765, pp. 160–169. Springer, Heidelberg (2005). https://doi.org/10.1007/11569541_17

    Chapter  Google Scholar 

  9. Geremia, E., Clatz, O., Menze, B.H., Konukoglu, E., Criminisi, A., Ayache, N.: Spatial decision forests for MS lesion segmentation in multi-channel magnetic resonance images. NeuroImage 57(2), 378–390 (2011)

    Article  Google Scholar 

  10. Ghafoorian, M., et al.: Location sensitive deep convolutional neural networks for segmentation of white matter hyperintensities (2016). CoRR abs/1610.04834

    Google Scholar 

  11. Ghafoorian, M., et al.: Transfer learning for domain adaptation in MRI: application in brain lesion segmentation. In: Descoteaux, M., Maier-Hein, L., Franz, A., Jannin, P., Collins, D.L., Duchesne, S. (eds.) MICCAI 2017. LNCS, vol. 10435, pp. 516–524. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-66179-7_59

    Chapter  Google Scholar 

  12. Isensee, F., Kickingereder, P., Wick, W., Bendszus, M., Maier-Hein, K.H.: No new-net. In: Crimi, A., Bakas, S., Kuijf, H., Keyvan, F., Reyes, M., van Walsum, T. (eds.) BrainLes 2018. LNCS, vol. 11384, pp. 234–244. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-11726-9_21

    Chapter  Google Scholar 

  13. Ji, S., Wei, B., Yu, Z., Yang, G., Yin, Y.: A new multistage medical segmentation method based on superpixel and fuzzy clustering. Comp. Math. Meth. Med. 2014, 747549:1–747549:13 (2014)

    MathSciNet  MATH  Google Scholar 

  14. Kamnitsas, K., et al.: Ensembles of multiple models and architectures for robust brain tumour segmentation. In: Crimi, A., Bakas, S., Kuijf, H., Menze, B., Reyes, M. (eds.) BrainLes 2017. LNCS, vol. 10670, pp. 450–462. Springer, Cham (2018). https://doi.org/10.1007/978-3-319-75238-9_38

    Chapter  Google Scholar 

  15. Korfiatis, P., Kline, T.L., Erickson, B.J.: Automated segmentation of hyperintense regions in FLAIR MRI using deep learning. Tomography J. Imaging Res. 2(4), 334–340 (2016). https://doi.org/10.18383/j.tom.2016.00166

    Article  Google Scholar 

  16. Ladgham, A., Torkhani, G., Sakly, A., Mtibaa, A.: Modified support vector machines for MR brain images recognition. In: Proceedings of CoDIT, pp. 032–035 (2013). https://doi.org/10.1109/CoDIT.2013.6689515

  17. Marcinkiewicz, M., Nalepa, J., Lorenzo, P.R., Dudzik, W., Mrukwa, G.: Segmenting brain tumors from MRI Using cascaded multi-modal U-Nets. In: Crimi, A., Bakas, S., Kuijf, H., Keyvan, F., Reyes, M., van Walsum, T. (eds.) BrainLes 2018. LNCS, vol. 11384, pp. 13–24. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-11726-9_2

    Chapter  Google Scholar 

  18. Mei, P.A., de Carvalho Carneiro, C., Fraser, S.J., Min, L.L., Reis, F.: Analysis of neoplastic lesions in magnetic resonance imaging using self-organizing maps. J. Neurol. Sci. 359(1–2), 78–83 (2015)

    Article  Google Scholar 

  19. Menze, et al.: The multimodal brain tumor image segmentation benchmark (brats). IEEE Trans. Med. Imag. 34(10), 1993–2024 (2015). https://doi.org/10.1109/TMI.2014.2377694

  20. Moeskops, P., Viergever, M.A., Mendrik, A.M., de Vries, L.S., Benders, M.J.N.L., Isgum, I.: Automatic segmentation of MR brain images with a convolutional neural network. IEEE Trans, Med. Imaging 35(5), 1252–1261 (2016). https://doi.org/10.1109/TMI.2016.2548501

    Article  Google Scholar 

  21. Myronenko, A.: 3D MRI brain tumor segmentation using autoencoder regularization. In: Crimi, A., Bakas, S., Kuijf, H., Keyvan, F., Reyes, M., van Walsum, T. (eds.) BrainLes 2018. LNCS, vol. 11384, pp. 311–320. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-11726-9_28

    Chapter  Google Scholar 

  22. Nalepa, J., Kawulok, M.: Adaptive genetic algorithm to select training data for support vector machines. In: Esparcia-Alcázar, A.I., Mora, A.M. (eds.) EvoApplications 2014. LNCS, vol. 8602, pp. 514–525. Springer, Heidelberg (2014). https://doi.org/10.1007/978-3-662-45523-4_42

    Chapter  Google Scholar 

  23. Nalepa, J., Kawulok, M.: Adaptive memetic algorithm enhanced with data geometry analysis to select training data for SVMs. Neurocomputing 185, 113–132 (2016)

    Article  Google Scholar 

  24. Park, M.T.M., et al.: Derivation of high-resolution MRI atlases of the human cerebellum at 3T and segmentation using multiple automatically generated templates. NeuroImage 95, 217–231 (2014)

    Article  Google Scholar 

  25. Pinto, A., Pereira, S., Correia, H., Oliveira, J., Rasteiro, D.M.L.D., Silva, C.A.: Brain tumour segmentation based on extremely rand. forest with high-level features. In: Proceedings of IEEE EMBC, pp. 3037–3040 (2015). https://doi.org/10.1109/EMBC.2015.7319032

  26. Pipitone, J., et al.: Multi-atlas segmentation of the whole hippocampus and subfields using multiple automatically generated templates. NeuroImage 101, 494–512 (2014)

    Article  Google Scholar 

  27. Rajendran, A., Dhanasekaran, R.: Fuzzy clustering and deformable model for tumor segmentation on MRI brain image: a combined approach. Procedia Eng. 30, 327–333 (2012). https://doi.org/10.1016/j.proeng.2012.01.868

    Article  Google Scholar 

  28. Ronneberger, O., Fischer, P., Brox, T.: U-net: convolutional networks for biomedical image segmentation (2015). CoRR abs/1505.04597

    Google Scholar 

  29. Saha, S., Bandyopadhyay, S.: MRI brain image segmentation by fuzzy symmetry based genetic clustering technique. In: Proceedings of IEEE CEC, pp. 4417–4424 (2007). https://doi.org/10.1109/CEC.2007.4425049

  30. Sauwen, N., et al.: Comparison of unsupervised classification methods for brain tumor segmentation using multi-parametric MRI. Neuroimage Clin. 12, 753–764 (2016)

    Article  Google Scholar 

  31. Sauwen, N., Acou, M., Sima, D.M., Veraart, J., Maes, F., Himmelreich, U., Achten, E., Huffel, S.V.: Semi-automated brain tumor segmentation on multi-parametric mri using regularized non-negative matrix factorization. BMC Med. Imaging 17(1), 29 (2017)

    Article  Google Scholar 

  32. Simi, V., Joseph, J.: Segmentation of glioblastoma multiforme from MR images - a comprehensive review. Egypt. J. Radiol. Nucl. Med. 46(4), 1105–1110 (2015)

    Article  Google Scholar 

  33. Soltaninejad, M., et al.: Automated brain tumour detection and segmentation using superpixel-based extremely randomized trees in FLAIR MRI. Int. J. Comp. Assist. Radiol. Surg. 12(2), 183–203 (2017)

    Article  Google Scholar 

  34. Taherdangkoo, M., Bagheri, M.H., Yazdi, M., Andriole, K.P.: An effective method for segmentation of MR brain images using the ant colony optimization algorithm. J. Dig. Imaging 26(6), 1116–1123 (2013)

    Article  Google Scholar 

  35. Verma, N., Cowperthwaite, M.C., Markey, M.K.: Superpixels in brain MR image analysis. In: Proceedings of IEEE EMBC, pp. 1077–1080 (2013). https://doi.org/10.1109/EMBC.2013.6609691

  36. Villanueva-Meyer, J.E., Mabray, M.C., Cha, S.: Current clinical brain tumor imaging. Neurosurgery 81(3), 397–415 (2017). https://doi.org/10.1093/neuros/nyx103

    Article  Google Scholar 

  37. Wu, W., Chen, A.Y.C., Zhao, L., Corso, J.J.: Brain tumor detection and segmentation in a CRF (conditional random fields) framework with pixel-pairwise affinity and superpixel-level features. Int. J. Comput. Assist. Radiol. Surg. 9(2), 241–253 (2013). https://doi.org/10.1007/s11548-013-0922-7

    Article  Google Scholar 

  38. Zhao, J., Meng, Z., Wei, L., Sun, C., Zou, Q., Su, R.: Supervised brain tumor segmentation based on gradient and context-sensitive features. Front. Neurosci. 13, 144 (2019). https://doi.org/10.3389/fnins.2019.00144, https://www.frontiersin.org/article/10.3389/fnins.2019.00144

  39. Zhao, X., Wu, Y., Song, G., Li, Z., Zhang, Y., Fan, Y.: A deep learning model integrating FCNNs and CRFs for brain tumor segmentation (2017). CoRR abs/1702.04528

    Google Scholar 

  40. Zhuge, Y., Krauze, A.V., Ning, H., Cheng, J.Y., Arora, B.C., Camphausen, K., Miller, R.W.: Brain tumor segmentation using holistically nested neural networks in MRI images. Med. Phys., 1–10 (2017). https://doi.org/10.1002/mp.12481

  41. Zikic, D., et al.: Decision forests for tissue-specific segmentation of high-grade gliomas in multi-channel MR. In: Ayache, N., Delingette, H., Golland, P., Mori, K. (eds.) MICCAI 2012. LNCS, vol. 7512, pp. 369–376. Springer, Heidelberg (2012). https://doi.org/10.1007/978-3-642-33454-2_46

    Chapter  Google Scholar 

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Acknowledgments

This research was supported by the National Centre for Research and Development (POIR.01.02.00-00-0030/15). JN was supported by the Silesian University of Technology funds (02/020/BKM19/0183).

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Correspondence to Jakub Nalepa .

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Kotowski, K., Nalepa, J., Dudzik, W. (2020). Detection and Segmentation of Brain Tumors from MRI Using U-Nets. In: Crimi, A., Bakas, S. (eds) Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries. BrainLes 2019. Lecture Notes in Computer Science(), vol 11993. Springer, Cham. https://doi.org/10.1007/978-3-030-46643-5_17

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  • DOI: https://doi.org/10.1007/978-3-030-46643-5_17

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