Abstract
We propose a hybrid segmentation pipeline based on the autoencoders’ capability of anomaly detection. To this end, we, first, introduce a new augmentation technique to generate synthetic paired images. Gaining advantage from the paired images, we propose a Normal Appearance Autoencoder (NAA) that is able to remove tumors and thus reconstruct realistic-looking, tumor-free images. After estimating the regions where the abnormalities potentially exist, a segmentation network is guided toward the candidate region. We tested the proposed pipeline on the BraTS 2019 database. The preliminary results indicate that the proposed model improved the segmentation accuracy of brain tumor subregions compared to the U-Net model.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Notes
References
Havaei, M., et al.: Brain tumor segmentation with deep neural networks. Med. Image Anal. 35, 18–31 (2017). https://doi.org/10.1016/J.MEDIA.2016.05.004
Sottoriva, A., et al.: Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Proc. Natl. Acad. Sci. U.S.A. 110, 4009–4014 (2013). https://doi.org/10.1073/pnas.1219747110
Zhao, X., Wu, Y., Song, G., Li, Z., Zhang, Y., Fan, Y.: A deep learning model integrating FCNNs and CRFs for brain tumor segmentation. Med. Image Anal. 43, 98–111 (2018). https://doi.org/10.1016/J.MEDIA.2017.10.002
Menze, B.H., van Leemput, K., Lashkari, D., Weber, M.-A., Ayache, N., Golland, P.: A generative model for brain tumor segmentation in multi-modal images. In: Jiang, T., Navab, N., Pluim, J.P.W., Viergever, M.A. (eds.) MICCAI 2010. LNCS, vol. 6362, pp. 151–159. Springer, Heidelberg (2010). https://doi.org/10.1007/978-3-642-15745-5_19
Li, H., Fan, Y.: Label propagation with robust initialization for brain tumor segmentation. In: 2012 9th IEEE International Symposium on Biomedical Imaging (ISBI), pp. 1715–1718. IEEE (2012)
Isensee, F., Kickingereder, P., Wick, W., Bendszus, M., Maier-Hein, K.H.: No new-net. In: Crimi, A., Bakas, S., Kuijf, H., Keyvan, F., Reyes, M., van Walsum, T. (eds.) BrainLes 2018. LNCS, vol. 11384, pp. 234–244. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-11726-9_21
Myronenko, A.: 3D MRI brain tumor segmentation using autoencoder regularization. In: Crimi, A., Bakas, S., Kuijf, H., Keyvan, F., Reyes, M., van Walsum, T. (eds.) BrainLes 2018. LNCS, vol. 11384, pp. 311–320. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-11726-9_28
Wang, C., Smedby, Ö.: Automatic brain tumor segmentation using 2.5D U-Nets. In: MICCAI Workshop on Multimodal Brain Tumor Segmentation (BRATS) Challenge, Québec, pp. 292–296 (2017)
Kingma, D.P., Welling, M.: Auto-encoding variational Bayes (2013)
Menze, B.H., Jakab, A., Bauer, S., Kalpathy-Cramer, J., Farahani, K., et al.: The multimodal brain tumor image segmentation benchmark (BRATS). IEEE Trans. Med. Imaging 34, 1993–2024 (2015). https://doi.org/10.1109/tmi.2014.2377694
Bakas, S., Akbari, H., Sotiras, A., Bilello, M., Rozycki, M., et al.: Advancing the cancer genome atlas glioma MRI collections with expert segmentation labels and radiomic features. Sci. Data. 4 (2017). https://doi.org/10.1038/sdata.2017.117. Article no. 170117
Bakas, S., Reyes, M., Jakab, A., Bauer, S., Rempfler, M., et al.: Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challenge. (2018)
Bakas, S., Akbari, H., Sotiras, A., Bilello, M., Rozycki, M., et al.: Segmentation labels and radiomic features for the pre-operative scans of the TCGA-GBM collection. Cancer Imaging Arch. (2017). https://doi.org/10.7937/k9/tcia.2017.klxwjj1q
Bakas, S., Akbari, H., Sotiras, A., Bilello, M., Rozycki, M., et al.: Segmentation labels and radiomic features for the pre-operative scans of the TCGA-LGG collection. Cancer Imaging Arch. (2017). https://doi.org/10.7937/k9/tcia.2017.gjq7r0ef
Tustison, N.J., et al.: N4ITK: improved N3 bias correction. IEEE Trans. Med. Imaging 29, 1310–1320 (2010). https://doi.org/10.1109/tmi.2010.2046908
Baur, C., Wiestler, B., Albarqouni, S., Navab, N.: Deep autoencoding models for unsupervised anomaly segmentation in brain MR images. In: Crimi, A., Bakas, S., Kuijf, H., Keyvan, F., Reyes, M., van Walsum, T. (eds.) BrainLes 2018. LNCS, vol. 11383, pp. 161–169. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-11723-8_16
Pérez, P., Gangnet, M., Blake, A., Pérez, P., Gangnet, M., Blake, A.: Poisson image editing. In: ACM SIGGRAPH 2003 Papers on - SIGGRAPH 2003, p. 313. ACM Press, New York (2003)
Astaraki, M., Toma-Dasu, I., Smedby, Ö., Wang, C.: Normal appearance autoencoder for lung cancer detection and segmentation. In: Shen, D., et al. (eds.) MICCAI 2019. LNCS, vol. 11769, pp. 249–256. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32226-7_28
Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28
Chen, X., Konukoglu, E.: Unsupervised detection of lesions in brain MRI using constrained adversarial auto-encoders (2018)
Acknowledgement
This study was supported by the Swedish Childhood Cancer Foundation (grant no. MT2016-0016), the Swedish innovation agency Vinnova (grant no. 2017-01247) and the Swedish Research Council (VR) (grant no. 2018-04375).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this paper
Cite this paper
Astaraki, M., Wang, C., Carrizo, G., Toma-Dasu, I., Smedby, Ö. (2020). Multimodal Brain Tumor Segmentation with Normal Appearance Autoencoder. In: Crimi, A., Bakas, S. (eds) Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries. BrainLes 2019. Lecture Notes in Computer Science(), vol 11993. Springer, Cham. https://doi.org/10.1007/978-3-030-46643-5_31
Download citation
DOI: https://doi.org/10.1007/978-3-030-46643-5_31
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-46642-8
Online ISBN: 978-3-030-46643-5
eBook Packages: Computer ScienceComputer Science (R0)