Abstract
Deep learning has demonstrated its superiority in automated identification of brain dementia based on neuroimaging data, such as structural MRIs. Previous methods typically assume that multi-site data are sampled from the same distribution. Such an assumption may not hold in practice due to the data heterogeneity caused by different scanning parameters and subject populations in multiple imaging sites. Even though several deep domain adaptation methods have been proposed to mitigate data heterogeneity between sites, they usually require a portion of labeled target data for model training, and rarely consider the potentially different contributions of different brain regions to disease prognosis. To address these limitations, we propose an attention-guided deep domain adaptation (AD\(^2\)A) framework for brain dementia prognosis, which does not need label information of the target domain and can automatically identify discriminative locations in whole-brain MR images. The proposed AD\(^2\)A framework consists of three key components: 1) a feature encoding module for representation learning of input MR images, 2) an attention discovery module for automatically locating dementia-related discriminative regions in brain MRIs, and 3) a domain transfer module with adversarial learning for knowledge transfer between the source and target domains. Extensive experiments have been conducted on three benchmark neuroimaging datasets, with results suggesting the effectiveness of our method in both tasks of brain dementia identification and disease progression prediction.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Falahati, F., Westman, E., Simmons, A.: Multivariate data analysis and machine learning in Alzheimer’s disease with a focus on structural magnetic resonance imaging. J. Alzheimer’s Dis. 41(3), 685–708 (2014)
Cuingnet, R., Gerardin, E., Tessieras, J., et al.: Automatic classification of patients with Alzheimer’s disease from structural MRI: a comparison of ten methods using the ADNI database. NeuroImage 56(2), 766–781 (2011)
Liu, M., Zhang, D., Shen, D.: Relationship induced multi-template learning for diagnosis of Alzheimer’s disease and mild cognitive impairment. IEEE Trans. Med. Imaging 35(6), 1463–1474 (2016)
Lian, C., et al.: Multi-channel multi-scale fully convolutional network for 3D perivascular spaces segmentation in 7T MR images. Med. Image Anal. 46, 106–117 (2018)
Lian, C., Liu, M., Zhang, J., Shen, D.: Hierarchical fully convolutional network for joint atrophy localization and Alzheimer’s disease diagnosis using structural MRI. IEEE Trans. Pattern Anal. Mach. Intell. 42(4), 880–893 (2018)
Liu, M., Zhang, J., Adeli, E., Shen, D.: Landmark-based deep multi-instance learning for brain disease diagnosis. Med. Image Anal. 43, 157–168 (2018)
Valiant, L.G.: A theory of the learnable. Commun. ACM 27(11), 1134–1142 (1984)
Wachinger, C., Reuter, M.: Domain adaptation for Alzheimer’s disease diagnostics. NeuroImage 139, 470–479 (2016)
Rieke, J., Eitel, F., Weygandt, M., Haynes, J.-D., Ritter, K.: Visualizing convolutional networks for MRI-based diagnosis of Alzheimer’s disease. In: Stoyanov, D., et al. (eds.) MLCN/DLF/IMIMIC -2018. LNCS, vol. 11038, pp. 24–31. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-02628-8_3
Hosseini-Asl, E., Keynton, R., El-Baz, A.: Alzheimer’s disease diagnostics by adaptation of 3D convolutional network. In: ICIP, pp. 126–130 (2016)
Woo, S., Park, J., Lee, J.Y., So Kweon, I.: Cbam: convolutional block attention module. In: ECCV, pp. 3–19 (2018)
Mu, Y., Gage, F.H.: Adult hippocampal neurogenesis and its role in Alzheimer’s disease. Mol. Neurodegeneration 6(1), 85 (2011). https://doi.org/10.1186/1750-1326-6-85
Ott, B.R., Cohen, R.A., Gongvatana, A., et al.: Brain ventricular volume and cerebrospinal fluid biomarkers of Alzheimer’s disease. J. Alzheimers Dis. 20(2), 647–657 (2010)
Zhou, B., Khosla, A., Lapedriza, A., Oliva, A., Torralba, A.: Learning deep features for discriminative localization. In: CVPR, pp. 2921–2929 (2016)
Ganin, Y., Ustinova, E., Ajakan, H., et al.: Domain-adversarial training of neural networks. J. Mach. Learn. Res. 17(1), 2030–2096 (2016)
Jack Jr., C.R., Bernstein, M.A., Fox, N.C., et al.: The Alzheimer’s disease neuroimaging initiative (ADNI): MRI methods. J. Magn. Reson. Imaging 27(4), 685–691 (2008)
Ellis, K.A., Bush, A.I., Darby, D., et al.: The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer’s disease. Int. Psychogeriatr. 21(4), 672–687 (2009)
Pan, S.J., Tsang, I.W., Kwok, J.T., Yang, Q.: Domain adaptation via transfer component analysis. IEEE Trans. Neural Networks 22(2), 199–210 (2010)
Fernando, B., Habrard, A., Sebban, M., Tuytelaars, T.: Unsupervised visual domain adaptation using subspace alignment. In: ICCV, pp. 2960–2967 (2013)
Gong, B., Shi, Y., Sha, F., Grauman, K.: Geodesic flow kernel for unsupervised domain adaptation. In: CVPR, pp. 2066–2073 (2012)
D’Amelio, M., Puglisi-Allegra, S., Mercuri, N.: The role of dopaminergic midbrain in Alzheimer’s disease: translating basic science into clinical practice. Pharmacol. Res. 130, 414–419 (2018)
De Marco, M., Venneri, A.: Volume and connectivity of the ventral tegmental area are linked to neurocognitive signatures of Alzheimer’s disease in humans. J. Alzheimers Dis. 63(1), 167–180 (2018)
Author information
Authors and Affiliations
Corresponding authors
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this paper
Cite this paper
Guan, H., Yang, E., Yap, PT., Shen, D., Liu, M. (2020). Attention-Guided Deep Domain Adaptation for Brain Dementia Identification with Multi-site Neuroimaging Data. In: Albarqouni, S., et al. Domain Adaptation and Representation Transfer, and Distributed and Collaborative Learning. DART DCL 2020 2020. Lecture Notes in Computer Science(), vol 12444. Springer, Cham. https://doi.org/10.1007/978-3-030-60548-3_4
Download citation
DOI: https://doi.org/10.1007/978-3-030-60548-3_4
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-60547-6
Online ISBN: 978-3-030-60548-3
eBook Packages: Computer ScienceComputer Science (R0)