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Building ICU In-hospital Mortality Prediction Model with Federated Learning

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Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 12500))

Abstract

In-hospital mortality prediction is a crucial task in the clinical settings. Nevertheless, individual hospitals alone often have limited amount of local data to build a robust model. Usually domain transfer of an in-hospital mortality prediction model built with publicly-accessible dataset is conducted. The study in [6] shows quantitatively that with more datasets from different hospitals being shared, the generalizability and performance of domain transfer improves. We see this as an area that Federated Learning could help. It enables collaborative modelling to take place in a decentralized manner, without the need for aggregating all datasets in one place. This chapter reports a recent pilot of building an in-hospital mortality model with Federated Learning. It empirically shows that Federated Learning does achieve a similar level of performance with centralized training, but with additional benefit of no dataset exchanging among different hospitals. It also compares the performance of two common federated aggregation algorithms empirically in the Intensive Care Unit (ICU) setting, namely FedAvg and FedProx.

This work was done when author Nicholas Lim was attached to AI Singapore as an apprentice.

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References

  1. Akkus, Z., Galimzianova, A., Hoogi, A., Rubin, D.L., Erickson, B.J.: Deep learning for brain MRI segmentation: state of the art and future directions. J. Digit. imaging 30(4), 449–459 (2017). https://doi.org/10.1007/s10278-017-9983-4

    Article  Google Scholar 

  2. Beaulieu-Jones, B.K., Yuan, W., Finlayson, S.G., Wu, Z.S.: Privacy-preserving distributed deep learning for clinical data. arXiv preprint arXiv:1812.01484 (2018)

  3. Dwork, C., Roth, A., et al.: The algorithmic foundations of differential privacy. Found. Trends Theoret. Comput. Sci. 9(3–4), 211–407 (2014)

    MathSciNet  MATH  Google Scholar 

  4. García-Laencina, P.J., Sancho-Gómez, J., Figueiras-Vidal, A.R.: Pattern classification with missing data: a review. Neural Comput. Appl. 19(2), 263–282 (2010). https://doi.org/10.1007/s00521-009-0295-6

  5. Huang, L., Shea, A.L., Qian, H., Masurkar, A., Deng, H., Liu, D.: Patient clustering improves efficiency of federated machine learning to predict mortality and hospital stay time using distributed electronic medical records. J. Biomed. Inform. 99, 103291 (2019)

    Article  Google Scholar 

  6. Johnson, A.E., Pollard, T.J., Naumann, T.: Generalizability of predictive models for intensive care unit patients. arXiv preprint arXiv:1812.02275 (2018)

  7. Kairouz, P., et al.: Advances and open problems in federated learning. arXiv preprint arXiv:1912.04977 (2019)

  8. Knaus, W.A., Draper, E.A., Wagner, D.P., Zimmerman, J.E.: APACHE II: a severity of disease classification system. Crit. Care Med. 13(10), 818–829 (1985)

    Article  Google Scholar 

  9. Konecný, J., McMahan, H.B., Ramage, D., Richtárik, P.: Federated optimization: distributed machine learning for on-device intelligence. CoRR abs/1610.02527 (2016), http://arxiv.org/abs/1610.02527

  10. Le Gall, J.R., Lemeshow, S., Saulnier, F.: A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. Jama 270(24), 2957–2963 (1993)

    Article  Google Scholar 

  11. Li, T., Sahu, A.K., Zaheer, M., Sanjabi, M., Talwalkar, A., Smith, V.: Federated optimization in heterogeneous networks. In: Dhillon, I.S., Papailiopoulos, D.S., Sze, V. (eds.) Proceedings of Machine Learning and Systems 2020, MLSys 2020, Austin, TX, USA, 2–4 March 2020. mlsys.org (2020). https://proceedings.mlsys.org/book/316.pdf

  12. Li, X., Huang, K., Yang, W., Wang, S., Zhang, Z.: On the convergence of FedAvg on Non-IID data. In: 8th International Conference on Learning Representations, ICLR 2020, Addis Ababa, Ethiopia, 26–30 April 2020. OpenReview.net (2020). https://openreview.net/forum?id=HJxNAnVtDS

  13. Liu, D., Miller, T.A., Sayeed, R., Mandl, K.D.: FADL: federated-autonomous deep learning for distributed electronic health record. CoRR abs/1811.11400 (2018), http://arxiv.org/abs/1811.11400

  14. McMahan, B., Moore, E., Ramage, D., Hampson, S., Arcas, B.A.Y.: Communication-efficient learning of deep networks from decentralized data. In: Artificial Intelligence and Statistics, pp. 1273–1282 (2017)

    Google Scholar 

  15. Pfohl, S.R., Dai, A.M., Heller, K.: Federated and differentially private learning for electronic health records. In: Machine Learning for Health (ML4H) at the 33rd Conference on Neural Information Processing System (NeurIPS 2019) (2019)

    Google Scholar 

  16. Pollard, T.J., Johnson, A.E., Raffa, J.D., Celi, L.A., Mark, R.G., Badawi, O.: The eICU collaborative research database, a freely available multi-center database for critical care research. Sci. Data 5, 180178 (2018)

    Article  Google Scholar 

  17. Prokhorenkova, L.O., Gusev, G., Vorobev, A., Dorogush, A.V., Gulin, A.: CatBoost: unbiased boosting with categorical features. In: Bengio, S., Wallach, H.M., Larochelle, H., Grauman, K., Cesa-Bianchi, N., Garnett, R. (eds.) Advances in Neural Information Processing Systems 31: Annual Conference on Neural Information Processing Systems 2018, NeurIPS 2018, 3–8 December 2018, Montréal, Canada, pp. 6639–6649 (2018). http://papers.nips.cc/paper/7898-catboost-unbiased-boosting-with-categorical-features

  18. Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28

    Chapter  Google Scholar 

  19. Singer, M., et al.: The third international consensus definitions for sepsis and septic shock (SEPSIS-3). Jama 315(8), 801–810 (2016)

    Article  Google Scholar 

  20. Stekhoven, D.J., Bühlmann, P.: MissForest’ non-parametric missing value imputation for mixed-type data. Bioinformatics 28(1), 112–118 (2011). https://doi.org/10.1093/bioinformatics/btr597

  21. Yang, Q., Liu, Y., Chen, T., Tong, Y.: Federated machine learning: concept and applications. ACM Trans. Intell. Syst. Technol. (TIST) 10(2), 1–19 (2019)

    Article  Google Scholar 

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Correspondence to Jianshu Weng .

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Dang, T.K., Tan, K.C., Choo, M., Lim, N., Weng, J., Feng, M. (2020). Building ICU In-hospital Mortality Prediction Model with Federated Learning. In: Yang, Q., Fan, L., Yu, H. (eds) Federated Learning. Lecture Notes in Computer Science(), vol 12500. Springer, Cham. https://doi.org/10.1007/978-3-030-63076-8_18

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  • DOI: https://doi.org/10.1007/978-3-030-63076-8_18

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  • Online ISBN: 978-3-030-63076-8

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