Skip to main content

COVID-19 X-ray Image Diagnostic with Deep Neural Networks

  • Conference paper
  • First Online:

Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 12558))

Abstract

The COVID-19 pandemic impacted all spheres of our society. The outbreak increased the pressure on public health systems, urging the scientific community to develop and evaluate methods to reliably diagnose patients. Driven by their effectiveness in medical imaging analysis, deep neural networks have been seen as a possible alternative to automatically diagnose COVID-19 patients from chest X-rays. Despite promising initial results, most analyses so far have been performed in small and under-represented datasets. Considering this, in this work, we evaluate state-of-the-art convolutional neural network architectures proposed in recent years by the deep learning field on images from COVIDx [24], a dataset consisting of 13, 975 chest X-ray from COVID-19, pneumonia, and healthy patients. In our experiments, we investigate the effect of data pre-processing steps and class unbalancing for this task. Our best model, an ensemble of several networks, achieved an accuracy above \(93\%\) in the testing set, showing promising results in a challenging dataset.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Apostolopoulos, I.D., Mpesiana, T.A.: Covid-19: automatic detection from X-ray images utilizing transfer learning with convolutional neural networks. Phys. Eng. Sci. Med. 43(2), 635–640 (2020). https://doi.org/10.1007/s13246-020-00865-4

    Article  PubMed  Google Scholar 

  2. Beck, B.R., Shin, B., Choi, Y., Park, S., Kang, K.: Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model. Comput. Struct. Biotechnol. J. 18, 784–790 (2020)

    Article  CAS  Google Scholar 

  3. Bizopoulos, P., Koutsouris, D.: Deep learning in cardiology. IEEE Rev. Biomed. Eng. 12, 168–193 (2018)

    Article  Google Scholar 

  4. Chen, T., Guestrin, C.: XGBoost: a scalable tree boosting system. In: ACM International Conference on Knowledge Discovery and Data Mining (ACM KDD), pp. 785–794 (2016)

    Google Scholar 

  5. Chollet, F.: Xception: deep learning with depthwise separable convolutions. In: IEEE Conference on Computer Vision and Pattern Recognition (CVPR), pp. 1251–1258 (2017)

    Google Scholar 

  6. Deng, J., Dong, W., Socher, R., Li, L.J., Li, K., Fei-Fei, L.: ImageNet: a large-scale hierarchical image database. In: IEEE Conference on Computer Vision and Pattern Recognition (CVPR), pp. 248–255 (2009)

    Google Scholar 

  7. Gao, Q., Bao, L., Mao, H., Wang, L., Xu, K., Yang, M., Li, Y., Zhu, L., Wang, N., Lv, Z., et al.: Development of an inactivated vaccine candidate for SARS-CoV-2. Science 369(6499), 77–81 (2020)

    Article  CAS  Google Scholar 

  8. He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: IEEE Conference on Computer Vision and Pattern Recognition (CVPR), pp. 770–778 (2016)

    Google Scholar 

  9. Howard, A.G., et al.: MobileNets: efficient convolutional neural networks for mobile vision applications. arXiv:1704.04861 (2017)

  10. Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al.: Clinical features of patients infected with 2019 novel coronavirus in wuhan, china. The Lancet 395(10223), 497–506 (2020)

    Article  CAS  Google Scholar 

  11. Huang, G., Liu, Z., Van Der Maaten, L., Weinberger, K.Q.: Densely connected convolutional networks. In: IEEE Conference on Computer Vision and Pattern Recognition (CVPR), pp. 4700–4708 (2017)

    Google Scholar 

  12. Kawahara, J., Hamarneh, G.: Multi-resolution-tract CNN with hybrid pretrained and skin-lesion trained layers. In: International Workshop on Machine Learning in Medical Imaging, pp. 164–171 (2016)

    Google Scholar 

  13. Lalmuanawma, S., Hussain, J., Chhakchhuak, L.: Applications of machine learning and artificial intelligence for Covid-19 (SARS-CoV-2) pandemic: A review. Chaos, Solitons & Fractals 139, 110059 (2020)

    Article  Google Scholar 

  14. Litjens, G., et al.: A survey on deep learning in medical image analysis. Med. Image Anal. 42, 60–88 (2017)

    Article  Google Scholar 

  15. Narin, A., Kaya, C., Pamuk, Z.: Automatic detection of coronavirus disease (COVID-19) using X-ray images and deep convolutional neural networks. arXiv:2003.10849 (2020)

  16. Raghu, M., Zhang, C., Kleinberg, J., Bengio, S.: Transfusion: understanding transfer learning for medical imaging. In: Advances in Neural Information Processing Systems (NIPS), pp. 3347–3357 (2019)

    Google Scholar 

  17. Rajpurkar, P., et al.: CheXNet: radiologist-level pneumonia detection on chest X-rays with deep learning. arXiv:1711.05225 (2017)

  18. Randhawa, G.S., Soltysiak, M.P., El Roz, H., de Souza, C.P., Hill, K.A., Kari, L.: Machine learning using intrinsic genomic signatures for rapid classification of novel pathogens: Covid-19 case study. PLoS ONE 15(4), e0232391 (2020)

    Article  CAS  Google Scholar 

  19. Selvaraju, R.R., Cogswell, M., Das, A., Vedantam, R., Parikh, D., Batra, D.: Grad-cam: Visual explanations from deep networks via gradient-based localization. In: IEEE International Conference on Computer Vision (ICCV), pp. 618–626 (2017)

    Google Scholar 

  20. Shen, W., Zhou, M., Yang, F., Yang, C., Tian, J.: Multi-scale convolutional neural networks for lung nodule classification. In: International Conference on Information Processing in Medical Imaging (IPMI), pp. 588–599 (2015)

    Google Scholar 

  21. Szegedy, C., Vanhoucke, V., Ioffe, S., Shlens, J., Wojna, Z.: Rethinking the inception architecture for computer vision. In: IEEE Conference on Computer Vision and Pattern Recognition (CVPR), pp. 2818–2826 (2016)

    Google Scholar 

  22. Tan, M., Le, Q.: EfficientNet: rethinking model scaling for convolutional neural networks. In: IEEE International Conference on Machine Learning (ICML), pp. 6105–6114 (2019)

    Google Scholar 

  23. Tuli, S., Tuli, S., Tuli, R., Gill, S.S.: Predicting the growth and trend of COVID-19 pandemic using machine learning and cloud computing. Internet of Things 11, 100222 (2020)

    Article  Google Scholar 

  24. Wang, L., Wong, A.: COVID-Net: a tailored deep convolutional neural network design for detection of COVID-19 cases from chest x-ray images. arXiv:2003.09871 (2020)

  25. Yan, L., et al.: An interpretable mortality prediction model for COVID-19 patients. Nat. Mach. Intell. 2, 1–6 (2020)

    Article  Google Scholar 

  26. Yosinski, J., Clune, J., Bengio, Y., Lipson, H.: How transferable are features in deep neural networks? In: Advances in Neural Information Processing Systems (NIPS), pp. 3320–3328 (2014)

    Google Scholar 

  27. Zhao, J., Zhang, M., Zhou, Z., Chu, J., Cao, F.: Automatic detection and classification of leukocytes using convolutional neural networks. Med. Biol. Eng. Comput. 55(8), 1287–1301 (2016). https://doi.org/10.1007/s11517-016-1590-x

    Article  PubMed  Google Scholar 

  28. Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., Si, H.R., Zhu, Y., Li, B., Huang, C.L., et al.: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579(7798), 270–273 (2020)

    Article  CAS  Google Scholar 

  29. Zoph, B., Vasudevan, V., Shlens, J., Le, Q.V.: Learning transferable architectures for scalable image recognition. In: IEEE Conference on Computer Vision and Pattern Recognition (CVPR), pp. 8697–8710 (2018)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rafael Padilha .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Oliveira, G. et al. (2020). COVID-19 X-ray Image Diagnostic with Deep Neural Networks. In: Setubal, J.C., Silva, W.M. (eds) Advances in Bioinformatics and Computational Biology. BSB 2020. Lecture Notes in Computer Science(), vol 12558. Springer, Cham. https://doi.org/10.1007/978-3-030-65775-8_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-65775-8_6

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-65774-1

  • Online ISBN: 978-3-030-65775-8

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics