Abstract
Brain tumors are the third most common type of cancer among young adults and an accurate diagnosis and treatment demands strict delineation of the tumor effected tissue. Brain tumor segmentation involves segmenting different tumor tissues, particularly, the enhancing tumor regions, non-enhancing tumor and necrotic regions, and edema. With increasing computational power and data sharing, computer vision algorithms, particularly deep learning approaches, have begun to dominate the field of medical image segmentation. Accurate tumor segmentation will help in surgery planning as well as monitor the progress in longitudinal studies enabling a better understanding of the factors effecting malignant growth. The objective of this paper is to provide an overview of the current state-of-the-art in brain tumor segmentation approaches, an idea of the available resources, and highlight the most promising research directions moving forward. We also intend to highlight the challenges that exist in this field, in particular towards the successful adoption of such methods to clinical practice.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
American association of neurological surgeons. https://www.aans.org/Patients/Neurosurgical-Conditions-and-Treatments/Brain-Tumors, Accessed 07 Dec 2020
Cancer.net. https://www.cancer.net/cancer-types/brain-tumor/statistics, Accessed 07 Jan 2019
Afshar, P., Mohammadi, A., Plataniotis, K.N.: Brain tumor type classification via capsule networks. In: 2018 25th IEEE International Conference on Image Processing (ICIP), pp. 3129–3133. IEEE (2018)
Afshar, P., Plataniotis, K.N., Mohammadi, A.: Capsule networks’ interpretability for brain tumor classification via radiomics analyses. In: 2019 IEEE International Conference on Image Processing (ICIP), pp. 3816–3820. IEEE (2019)
Anwar, S.M., Altaf, T., Rafique, K., RaviPrakash, H., Mohy-ud-Din, H., Bagci, U.: A survey on recent advancements for AI enabled radiomics in neuro-oncology. In: Mohy-ud-Din, H., Rathore, S. (eds.) RNO-AI 2019. LNCS, vol. 11991, pp. 24–35. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-40124-5_3
Anwar, S.M., Majid, M., Qayyum, A., Awais, M., Alnowami, M., Khan, M.K.: Medical image analysis using convolutional neural networks: a review. J. Med. Syst. 42(11), 226 (2018)
Bakas, S., et al.: Advancing the cancer genome atlas glioma MRI collections with expert segmentation labels and radiomic features. Sci. Data 4, 170117 (2017)
Bakas, S., et al.: Identifying the best machine learning algorithms for brain tumor segmentation, progression assessment, and overall survival prediction in the brats challenge. arXiv preprint arXiv:1811.02629 (2018)
Choi, K.S., Choi, S.H., Jeong, B.: Prediction of IDH genotype in gliomas with dynamic susceptibility contrast perfusion MR imaging using an explainable recurrent neural network. Neuro-oncology 21(9), 1197–1209 (2019)
Cirillo, M.D., Abramian, D., Eklund, A.: Vox2Vox: 3D-GAN for brain tumour segmentation. arXiv preprint arXiv:2003.13653 (2020)
Clark, K., et al.: The cancer imaging archive (TCIA): maintaining and operating a public information repository. J. Digital Imaging 26(6), 1045–1057 (2013)
Feng, X., Tustison, N.J., Patel, S.H., Meyer, C.H.: Brain tumor segmentation using an ensemble of 3D U-nets and overall survival prediction using radiomic features. Front. Comput. Neurosci. 14, 25 (2020)
Fukuma, R., et al.: Prediction of IDH and TERT promoter mutations in low-grade glioma from magnetic resonance images using a convolutional neural network. Sci. Rep. 9(1), 1–8 (2019)
Havaei, M., et al.: Brain tumor segmentation with deep neural networks. Med. Image Anal. 35, 18–31 (2017)
Huang, P., et al.: CoCa-GAN: common-feature-learning-based context-aware generative adversarial network for glioma grading. In: Shen, D., Liu, T., Peters, T.M., Staib, L.H., Essert, C., Zhou, S., Yap, P.-T., Khan, A. (eds.) MICCAI 2019. LNCS, vol. 11766, pp. 155–163. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32248-9_18
Hussain, S., Anwar, S.M., Majid, M.: Brain tumor segmentation using cascaded deep convolutional neural network. In: 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 1998–2001. IEEE (2017)
Hussain, S., Anwar, S.M., Majid, M.: Segmentation of glioma tumors in brain using deep convolutional neural network. Neurocomputing 282, 248–261 (2018)
Jungo, A., Balsiger, F., Reyes, M.: Analyzing the quality and challenges of uncertainty estimations for brain tumor segmentation. Front. Neurosci. 14, 282 (2020)
Kamnitsas, K., et al.: Efficient multi-scale 3D CNN with fully connected CRF for accurate brain lesion segmentation. Med. Image Anal. 36, 61–78 (2017)
Lee, H., et al.: An explainable deep-learning algorithm for the detection of acute intracranial haemorrhage from small datasets. Nat. Biomed. Eng. 3(3), 173 (2019)
Maier, O., et al.: Isles 2015-a public evaluation benchmark for ischemic stroke lesion segmentation from multispectral mri. Med. Image Anal. 35, 250–269 (2017)
Nigri, E., Ziviani, N., Cappabianco, F., Antunes, A., Veloso, A.: Explainable deep CNNs for MRI-based diagnosis of alzheimer’s disease. arXiv preprint arXiv:2004.12204 (2020)
Pei, L., Bakas, S., Vossough, A., Reza, S.M., Davatzikos, C., Iftekharuddin, K.M.: Longitudinal brain tumor segmentation prediction in MRI using feature and label fusion. Biomed. Signal Process. Control 55, 101648 (2020)
Schmainda, K., Prah, M., Connelly, J., Rand, S.: Glioma DSC-MRI perfusion data with standard imaging and rois. The Cancer Imaging Archive (2016). https://doi.org/10.7937/K9/TCIA.2016.5DI84Js8
Sharma, D., Shanis, Z., Reddy, C.K., Gerber, S., Enquobahrie, A.: Active learning technique for multimodal brain tumor segmentation using limited labeled images. In: Wang, Q., et al. (eds.) DART/MIL3ID -2019. LNCS, vol. 11795, pp. 148–156. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-33391-1_17
Swati, Z.N.K., et al.: Brain tumor classification for MR images using transfer learning and fine-tuning. Comput. Med. Imaging Graph. 75, 34–46 (2019)
Szychot, E., et al.: Predicting outcome in childhood diffuse midline gliomas using magnetic resonance imaging based texture analysis. J. Neuroradiol. (2020)
Tiwari, A., Srivastava, S., Pant, M.: Brain tumor segmentation and classification from magnetic resonance images: review of selected methods from 2014 to 2019. Pattern Recogn. Lett. 131, 244–260 (2020)
Vidoni, E.D.: The whole brain atlas: www.med.harvard.edu/aanlib. J. Neurologic Phys. Therapy 36(2), 108 (2012)
Wang, G., Li, W., Aertsen, M., Deprest, J., Ourselin, S., Vercauteren, T.: Aleatoric uncertainty estimation with test-time augmentation for medical image segmentation with convolutional neural networks. Neurocomputing 338, 34–45 (2019)
Wang, G., Li, W., Vercauteren, T., Ourselin, S.: Automatic brain tumor segmentation based on cascaded convolutional neural networks with uncertainty estimation. Front. Comput. Neurosci. 13, 56 (2019)
Wang, G., et al.: Deepigeos: a deep interactive geodesic framework for medical image segmentation. IEEE Trans. Pattern Anal. Mach. Intell. 41(7), 1559–1572 (2018)
Windisch, P., et al.: Implementation of model explainability for a basic brain tumor detection using convolutional neural networks on MRI slices. Neuroradiology 62, 1515–1518 (2020)
Yang, Q., Liu, Y., Chen, T., Tong, Y.: Federated machine learning: concept and applications. ACM Trans. Intell. Syst. Technol. (TIST) 10(2), 1–19 (2019)
Yuan, B., Zhang, N., Yan, J., Cheng, J., Lu, J., Wu, J.: Tumor grade-related language and control network reorganization in patients with left cerebral glioma. Cortex (2020)
Zhao, X., Wu, Y., Song, G., Li, Z., Zhang, Y., Fan, Y.: A deep learning model integrating FCNNs and CRFs for brain tumor segmentation. Med. Image Anal. 43, 98–111 (2018)
Zhou, C., Ding, C., Wang, X., Lu, Z., Tao, D.: One-pass multi-task networks with cross-task guided attention for brain tumor segmentation. IEEE Trans. Image Process. 29, 4516–4529 (2020)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this paper
Cite this paper
Yousaf, S., RaviPrakash, H., Anwar, S.M., Sohail, N., Bagci, U. (2020). State-of-the-Art in Brain Tumor Segmentation and Current Challenges. In: Kia, S.M., et al. Machine Learning in Clinical Neuroimaging and Radiogenomics in Neuro-oncology. MLCN RNO-AI 2020 2020. Lecture Notes in Computer Science(), vol 12449. Springer, Cham. https://doi.org/10.1007/978-3-030-66843-3_19
Download citation
DOI: https://doi.org/10.1007/978-3-030-66843-3_19
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-66842-6
Online ISBN: 978-3-030-66843-3
eBook Packages: Computer ScienceComputer Science (R0)