Abstract
4D flow magnetic resonance imaging (MRI) and in-silico simulations have seen widespread use in the characterization of blood flow patterns in the aorta and subsequent calibration of haemodynamic computational models. Computational Fluid Dynamics (CFD) simulations offer a complete overview on local haemodynamics but require patient-specific boundary conditions to provide realistic simulations. Despite the inherent low spatial resolution of 4D flow MRI near the boundaries, it can provide rich haemodynamic details to improve existing simulations. Unfortunately, very few works exist imaging the left atria (LA) with 4D flow MRI due to the acquisition and processing challenges associated to the low magnitude of velocities, the small size of the structure and the complexity of blood flow patterns, especially in pathologies such as atrial fibrillation (AF). The main goal of this study was to develop a computational pipeline to extract qualitative and quantitative indices of LA haemodynamics from 4D flow MRI to: assess differences between normal and AF left atria; and calibrate existing fluid models with improved boundary conditions. The preliminary results obtained in two cases demonstrate the potential of 4D flow MRI data to identify haemodynamic differences between healthy and AF left atria. Furthermore, it can help to bring flow computational simulations to a new level of realism, allowing more degrees of freedom to better capture the complexity of LA blood flow patterns.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Bustamante, M., et al.: Atlas-based analysis of 4D flow CMR: automated vessel segmentation and flow quantification. J. Cardiovasc. Magn. Reson. 17(1), 87 (2015). https://doi.org/10.1186/s12968-015-0190-5
Di Achille, P., Tellides, G., Figueroa, C.A., Humphrey, J.D.: A haemodynamic predictor of intraluminal thrombus formation in abdominal aortic aneurysms. Proc. R. Soc. A Math. Phys. Eng. Sci. 470(2172), 20140163–20140163 (2014)
Glikson, M., et al.: EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion - an update. EP Europace 22(2), 184–184 (2019)
Koltukluoğlu, T.S.: Fourier spectral dynamic data assimilation: interlacing CFD with 4D flow MRI. In: Shen, D., et al. (eds.) MICCAI 2019. LNCS, vol. 11765, pp. 741–749. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32245-8_82
Lantz, J., et al.: Impact of pulmonary venous inflow on cardiac flow simulations: comparison with in vivo 4D flow MRI. Ann. Biomed. Eng. 47(2), 413–424 (2019)
Markl, M., et al.: Left atrial and left atrial appendage 4D blood flow dynamics in atrial fibrillation. Circ. Cardiovasc. Imaging 9(9), e004984–e004984 (2016)
Masci, A., et al.: The impact of left atrium appendage morphology on stroke risk assessment in atrial fibrillation: a computational fluid dynamics study. Front. Physiol. 9, 1938–1938 (2019)
Mill, J., et al.: Impact of flow dynamics on device-related thrombosis after left atrial appendage occlusion. Can. J. Cardiol. 36(6), 968.e13–968.e14 (2020)
Mill, J., Olivares, A.L., Noailly, J., Bijnens, B., Freixa, X., Camara, O.: Optimal boundary conditions in fluid simulations fo predicting occluder-related thrombus formation in the left atria. In: Computational and Mathematical Biomedical Engineering -CMBE 2019, pp. 256–259 (2019)
Otani, T., Al-Issa, A., Pourmorteza, A., McVeigh, E.R., Wada, S., Ashikaga, H.: A computational framework for personalized blood flow analysis in the human left atrium. Ann. Biomed. Eng. 44(11), 3284–3294 (2016). https://doi.org/10.1007/s10439-016-1590-x
Petersson, S., Dyverfeldt, P., Ebbers, T.: Assessment of the accuracy of MRI wall shear stress estimation using numerical simulations. J. Magn. Reson. Imaging 36(1), 128–138 (2012)
Soulat, G., McCarthy, P., Markl, M.: 4D flow with MRI. Annu. Rev. Biomed. Eng. 22(1), 103–126 (2020)
Veronesi, F., et al.: Quantification of mitral apparatus dynamics in functional and ischemic mitral regurgitation using real-time 3-dimensional echocardiography. J. Am. Soc. Echocardiogr. 21(4), 347–354 (2008)
Funding
This work was supported by the Agency for Management of University and Research Grants of the Generalitat de Catalunya under the Grants for the Contracting of New Research Staff Programme - FI (2020 FI_B 00608) and the Spanish Ministry of Economy and Competitiveness under the Programme for the Formation of Doctors (PRE2018-084062), the Maria de Maeztu Units of Excellence Programme (MDM-2015-0502) and the Retos investigación project (RTI2018-101193-B-I00).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Ethics declarations
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Rights and permissions
Copyright information
© 2021 Springer Nature Switzerland AG
About this paper
Cite this paper
Morales, X. et al. (2021). 4D Flow Magnetic Resonance Imaging for Left Atrial Haemodynamic Characterization and Model Calibration. In: Puyol Anton, E., et al. Statistical Atlases and Computational Models of the Heart. M&Ms and EMIDEC Challenges. STACOM 2020. Lecture Notes in Computer Science(), vol 12592. Springer, Cham. https://doi.org/10.1007/978-3-030-68107-4_16
Download citation
DOI: https://doi.org/10.1007/978-3-030-68107-4_16
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-68106-7
Online ISBN: 978-3-030-68107-4
eBook Packages: Computer ScienceComputer Science (R0)