Skip to main content

Thyroid Nodule Cell Classification in Cytology Images Using Transfer Learning Approach

  • Conference paper
  • First Online:

Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 1383))

Abstract

Analysis of fine needle aspiration cytology FNAC slides of thyroid nodules is a very crucial test before the preoperative diagnosis of thyroid malignancy. Cytology slides may be composed of different types of cells. Differentiating between cancerous cells and healthy cells plays an important role in the treatment. However, the conventional visual inspection is very time consuming and the process might endure inaccuracies because of the subject-level assessment. To the best of our knowledge, no work has been done for the multi-class cell level classification of thyroid nodules. In this paper, we propose a method for classification of cytology images at the cell level by using fine-tuned VGG-19 and AlexNet models, exploiting the transfer learning approach to better fit the model for classification of our dataset. Model evaluations are done by calculating the precision, recall, F1-score, and accuracy. Although the data is highly imbalanced, but both model have shown very good performance by achieving an accuracy of 93.05% and 92.88% by VGG-19 and AlexNet respectively.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Taher, F., et al.: Bayesian classification and artificial neural network methods for lung cancer early diagnosis. In: 19th IEEE International Conference on Electronics, Circuits, and Systems, ICECS, pp. 773–776 (2012). https://doi.org/10.1109/ICECS.2012.6463545

  2. Taher, F., et al.: Extraction and segmentation of sputum cells for lung cancer early diagnosis. Algorithms 6(3), 512–531 (2013). https://doi.org/10.3390/a6030512

    Article  MATH  Google Scholar 

  3. El Khatib, A., et al.: Automatic polyp detection: a comparative study. In: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2015-November, pp. 2669–2672 (2015). https://doi.org/10.1109/EMBC.2015.7318941

  4. Taha, B., et al.: Automatic polyp detection in endoscopy videos: a survey. In: Proceedings of the 13th IASTED International Conference on Biomedical Engineering, BioMed, pp. 233–240 (2017). https://doi.org/10.2316/P.2017.852-031

  5. Taha, B., et al.: Classification of cervical-cancer using pap-smear images: a convolutional neural network approach. In: Communications in Computer and Information Science, vol. 723 (2017). https://doi.org/10.1007/978-3-319-60964-5_23

  6. Reda, I., et al.: Computer-aided diagnostic tool for early detection of prostate cancer. In: Proceedings - International Conference on Image Processing, ICIP, vol. 2016-August, pp. 2668–2672 (2016). https://doi.org/10.1109/ICIP.2016.7532843

  7. Reda, I., et al.: A comprehensive non-invasive framework for diagnosing prostate cancer. Comput. Biol. Med. 81, 148–158 (2017). https://doi.org/10.1016/j.compbiomed.2016.12.010

    Article  Google Scholar 

  8. Alkadi, R., et al.: A deep learning-based approach for the detection and localization of prostate cancer in t2 magnetic resonance images. J. Digital Imaging 32(5), 793–807 (2019). https://doi.org/10.1007/s10278-018-0160-1

    Article  Google Scholar 

  9. Javed, S., Mahmood, A., Werghi, N., et al.: Multiplex cellular communities in multi-gigapixel colorectal cancer histology images for tissue phenotyping. IEEE Trans. Image Process. 29, 9204–9219 (2020). https://doi.org/10.1109/TIP.2020.3023795

    Article  Google Scholar 

  10. Raja, H., Hassan, T., Akram, M.U., et al.: Clinically verified hybrid deep learning system for retinal ganglion cells aware grading of glaucomatous progression. IEEE Trans. Biomed. Eng. (2020). https://doi.org/10.1109/TBME.2020.3030085

  11. Hassan, T., Akram, M.U., Werghi, N., et al.: RAG-FW: a hybrid convolutional framework for the automated extraction of retinal lesions and lesion-influenced grading of human retinal pathology. IEEE J. Biomed. Health Inf. 25, 108–120 (2020). https://doi.org/10.1109/JBHI.2020.2982914

    Article  Google Scholar 

  12. Keles, A.: Keles : a ESTDD: expert system for thyroid diseases diagnosis. Expert Syst. Appl. 34, 242–246 (2008)

    Article  Google Scholar 

  13. Nam-Goong, I.S., et al.: Ultrasonography-guided fine-needle aspiration of thyroid incidentaloma: correlation with pathological findings. Clin. Endocrinol. 60, 21–28 (2004)

    Article  Google Scholar 

  14. Meinkoth, J.H., Cowell, R.L.: Sample collection and preparation in cytology: increasing diagnostic yield. Vet. Clin. North Am. Small Anim. Pract. 32(6), 1187–1207 (2002)

    Article  Google Scholar 

  15. Teramoto, A., et al.: Automated classification of benign and malignant cells from lung cytological images using deep convolutional neural network. Inf. Med. 16, 100205 (2019). https://doi.org/10.1016/j.imu.2019.100205

    Article  Google Scholar 

  16. Dholey, M. et al.: A Computer Vision Approach for Lung Cancer Classification Using FNAC-Based Cytological Images (2018)

    Google Scholar 

  17. Su, K., et al.: A novel deep learning based framework for the detection and classification of breast cancer using transfer learning. Pattern Recogn. Lett. 125, 1–6 (2019)

    Article  Google Scholar 

  18. Saikia, A., et al.: Comparative assessment of CNN architectures for classification of breast FNAC images. Tissue Cell 57, 8–14 (2019). https://doi.org/10.1016/j.tice.2019.02.001

    Article  Google Scholar 

  19. Wu, M., et al.: Automatic classification of ovarian cancer types from cytological images using deep convolutional neural networks. Biosci. Rep. 38, BSR20180289 (2018). https://doi.org/10.1042/BSR20180289

    Article  Google Scholar 

  20. Daskalakis, A., et al.: Design of a multi-classifier system for discriminating benign from malignant thyroid nodules using routinely H&E-stained cytological images. Comput. Biol. Med. 38(2), 196–203 (2008). https://doi.org/10.1016/j.compbiomed.2007.09.005

    Article  Google Scholar 

  21. Guan, Q., et al.: Deep convolutional neural network VGG-16 model for differential diagnosing of papillary thyroid carcinomas in cytological images: a pilot study. J. Cancer 10(20), 4876–4882 (2019). https://doi.org/10.7150/jca.28769

    Article  Google Scholar 

  22. Gopinath, B., Shanthi, N.: Support Vector Machine based diagnostic system for thyroid cancer using statistical texture features. Asian Pac. J. Cancer Prev. APJCP 14(1), 97–102 (2013). https://doi.org/10.7314/apjcp.2013.14.1

    Article  Google Scholar 

  23. Sanyal, P., et al.: Artificial intelligence in cytopathology: a neural network to identify papillary carcinoma on thyroid fine-needle aspiration cytology smears. J. Pathol. Inf 9, 43 (2018)

    Article  Google Scholar 

  24. Long, M., et al.: Learning transferable features with deep adaptation networks. In: Proceedings of the 32nd International Conference on Machine Learning, Lille, France, pp. 97–105 (2015)

    Google Scholar 

  25. Hosny, K.M., et al.: Skin cancer classification using deep learning and transfer learning. In: 9th Cairo International Biomedical Engineering Conference (CIBEC), Cairo, Egypt, pp. 90-93 (2018). https://doi.org/10.1109/CIBEC.2018.8641762

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Naoufel Werghi .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Bakht, A.B., Javed, S., Dina, R., Almarzouqi, H., Khandoker, A., Werghi, N. (2021). Thyroid Nodule Cell Classification in Cytology Images Using Transfer Learning Approach. In: Abraham, A., et al. Proceedings of the 12th International Conference on Soft Computing and Pattern Recognition (SoCPaR 2020). SoCPaR 2020. Advances in Intelligent Systems and Computing, vol 1383. Springer, Cham. https://doi.org/10.1007/978-3-030-73689-7_52

Download citation

Publish with us

Policies and ethics