Abstract
Drug information includes indications, contraindications, adverse reactions and other specific descriptions, which can provide a basis and support for rational clinical rational drug use and clinical decision-making. A Chinese medicine knowledge base with interrelated disease and drug information interrelated can effectively monitor the therapeutic effects of drugs on diseases and provide knowledge resources for drug research. In this paper, the multi-source Chinese Medicine Knowledge Base (CMKB) is constructed in view of the important role of drug information in clinical medication, auxiliary diagnosis, disease risk prediction and other practical applications. CMKB takes the mainstream medical resources such as the China Disease Knowledge Total Database and Dingxiangyuan as data sources. On the basis of the knowledge description system and classification system of the medicine database, CMKB standardizes the classification of drugs from multiple sources and forms corresponding detailed knowledge descriptions. CMKB constructed contains 14,141 drugs, which are described in detail from 7 aspects such as indications, contraindications and classification. Knowledge association between drug entities and disease entities is established through named entity recognition. The accuracy of named entity recognition reaches 90.6% and 91.4% as assessed by different models. CMKB constructed in this paper can be a useful supplement for the Chinese Medical Knowledge Graph (CMeKG) and will provide support for intelligent diagnosis and clinical decision-making.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Notes
References
Lv, W.-H., Jiang, X., Wang, S.-H.: Establishment and application of drug instruction database (药品说明书数据库的建立与应用). Chin. Pharm. (中国药房). 18, 316–318 (2007)
Cai, Y.-P.: Guidance of drug product instruction in clinical medication (药品说明书在临床用药中的指导作用). Nursing Res. Second Half Month (护理研究:下半月). 20, 1850–1851(2004).
Liu, L., Wang, X.: Development of knowledge base for precision medicine (精准医学知识库的构建). Chin. J. Med. Libr. Inf. Sci. (中华医学图书情报杂志). 27, 1–9 (2018)
Yang, Z.: A knowledge database based on knowledge mining and knowledge organization——Introduction to clinical medicine knowledge service system of China disease knowledge total database (一种基于知识挖掘与知识组织的知识型数据库——中国疾病知识总库之临床医药学知识服务系统介绍). Chin. J. Med. Libr. Inf. Sci. (中华医学图书情报杂志) 17, 63–65 (2008)
Hou, L., Qian, Q., Huang, L.-H., et al.: Discussion on clinical medicine knowledge base system construction based on ontology (基于本体的临床医学知识库系统构建探讨). J. Med. Inf. (医学信息学杂志). 32, 42–47 (2011)
Ge, C.-X., Zhang, Y.-S., Chen, W.-H., Duan, H.-L., Li, H.-Y.: Construction and statistical analysis of an adverse drug reaction knowledgebase (药物不良反应知识库的建设以及统计分析). Chin. J. Hosp. Pharm. (中国医院药学杂志). 35, 765–769 (2015)
Wu, J., Zhang, Q., Qi, D.-X., Lin, W.-W.: Medicine knowledge base system for clinical path support system (面向临床路径支撑系统的药品知识库系统). Herald Med. (医药导报). 29, 1106–1110 (2010)
Xu, F., Zeng, S.: Construction of drug attribute classification knowledge base and its application in data analysis of pharmaceutical administration in our hospital (药品属性分类知识库的构建及其在我院药事管理数据分析中的应用). Chin. Pharm. (中国药房). 30, 2737–2741 (2019)
Zhang, L., Yang, Y.-F., Zhu, J.-P., Hu, J,-Q.: Application of intelligent management system of medicine knowledge base for digestive system (消化系统用药知识库智能化管理系统的应用). China Pharmacist (中国药师). 22, 378–380 (2019)
Zan, H.-Y., Dou, H.-Y., Jia, Y.-X., et al.: Construction of Chinese medical knowledge graph based on multi-source corpus (基于多来源文本的中文医学知识图谱的构建). J. Zhengzhou Univ. (Natural Science Edition) (郑州大学学报(理学版)). 52, 45–51 (2020)
Ao, D.-M., Yang, Y.-F., Sui, Z.-F., et al.: Preliminary study on the construction of Chinese medical knowledge graph (中文医学知识图谱CMeKG构建初探). J. Chin. Inf. Process. (中文信息学报). 33, 1–9 (2019)
World Health Organization. International Statistical Classification of Diseases and Related Health Problems. (10th Revision) [OL] https://icd.who.int/browsel0/2016/en
Mou, D.-M., Zhang, Y.-X., Huang, L.-L., et al.: Constructing medical ontology based on SNOMED CT and FCA (基于SNOMEDCT和FCA的医学领域本体构建研究). J. Chin. Soc. Sci. Tech. Inf. (情报学报). 32, 653–662 (2013)
Amarilli, A., Galárraga, L., Preda, N., Suchanek, F.M.: Recent topics of research around the YAGO knowledge base. In: Chen, L., Jia, Y., Sellis, T., Liu, G. (eds.) APWeb 2014. LNCS, vol. 8709, pp. 1–12. Springer, Cham (2014). https://doi.org/10.1007/978-3-319-11116-2_1
Nelson, S.J., Douglas Johnston, W., Humphreys, B.L.: Relationships in medical subject headings (MeSH). In: Bean, C.A., Green, R. (eds.) Relationships in the Organization of Knowledge, pp. 171–184. Springer, Dordrecht (2001). https://doi.org/10.1007/978-94-015-9696-1_11
Meng, L.-Y..: To establish a complete and standardized drug information database to improve the level of drug management and pharmacy services (建立完整、规范的药品信息数据库,提高药品管理和药学服务水平). Med. Inf. (医学信息:医学与计算机应用). 14, 672–673 (2001)
Zhu, X.-D.: Sharing in the mobile medical industry: Taking Dingxiangyuan and Weiyi as examples (移动医疗行业的共享——以丁香园、微医为例). Hangzhou Weekly (杭州(我们)), pp. 49–52 (2017)
Organized and compiled by the Expert Committee on rational drug use of the Ministry of Health: MCDEX Clinical Medication Guidelines for Chinese Physicians and Pharmacists (MCDEX中国医师药师临床用药指南). Chongqing Publishing Group. 6, 2737–2741 (2009)
Yue, D., Zhang, K., Zhuang, L., Zhao, X., Byambasuren, O., Zan, H.: Annotation scheme and specification for named entities and relations on Chinese medical knowledge graph. In: Hong, J.-F., Zhang, Y., Liu, P. (eds.) CLSW 2019. LNCS (LNAI), vol. 11831, pp. 563–574. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-38189-9_58
Artstein, R., Poesio, M.: Inter-coder agreement for computational linguistics. Comput. Linguist. 34, 555–596 (2008)
Acknowledgment
We thank the anonymous reviewers for their constructive comments, and gratefully acknowledge the support of National Key Research and Development Project (Grant No. 2017YFB1002101), Major Program of National Social Science Foundation of China (Grant No. 17ZDA138), China Postdoctoral Science Foundation (Grant No. 2019TQ0286), Science and Technique Program of Henan Province (Grant No. 192102210260), Medical Science and Technique Program Co-sponsored by Henan Province and Ministry (Grant No. SB201901021), Key Scientific Research Program of Higher Education of Henan Province (Grant No. 19A520003, 20A520038, 20A320070), the MOE Layout Foundation of Humanities and Social Sciences (Grant No. 20YJA740033), Henan Social Science Planning Project (Grant No. 2019BYY016).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Switzerland AG
About this paper
Cite this paper
Zhang, K., Ren, X., Zhuang, L., Zan, H., Zhang, W., Sui, Z. (2021). Construction of Chinese Medicine Knowledge Base. In: Liu, M., Kit, C., Su, Q. (eds) Chinese Lexical Semantics. CLSW 2020. Lecture Notes in Computer Science(), vol 12278. Springer, Cham. https://doi.org/10.1007/978-3-030-81197-6_56
Download citation
DOI: https://doi.org/10.1007/978-3-030-81197-6_56
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-81196-9
Online ISBN: 978-3-030-81197-6
eBook Packages: Computer ScienceComputer Science (R0)