Abstract
Non-small-cell lung cancer (NSCLC) is the most common lung cancer with poor prognosis. Prognostic prediction is significant in improving the prognosis of NSCLC patients. Clinical information and multi-omics data including gene expression, miRNA, copy number variations, and DNA methylation are closely related to NSCLC prognosis. In this study, we propose a deep neural network to conduct prognostic prediction for NSCLC patients based on all five types of data. Given the high dimensional features of the omics data, past works reduce the feature dimension by regression analysis or correlation sorting algorithms. A shortcoming of these methods is that only a small number of features are considered. To overcome it, we propose a convolution neural network-based feature transformation method, which considers all features and extracts the abstract representations of the omics data. Based on the representations, we predict the five-year survival status of NSCLC patients. The results show that our method achieves a more precise prediction than previous work, with the areas under the curve improved from 0.8163 to 0.8508 and the accuracy improved from 0.7544 to 0.8096.
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Zhang, ZS., Xu, F., Jiang, HJ., Chen, ZH. (2021). Prognostic Prediction for Non-small-Cell Lung Cancer Based on Deep Neural Network and Multimodal Data. In: Huang, DS., Jo, KH., Li, J., Gribova, V., Premaratne, P. (eds) Intelligent Computing Theories and Application. ICIC 2021. Lecture Notes in Computer Science(), vol 12838. Springer, Cham. https://doi.org/10.1007/978-3-030-84532-2_49
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