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Russian Conference on Artificial Intelligence

RCAI 2021: Artificial Intelligence pp 3–16Cite as

Heterogeneous Formal Neurons and Modeling of Multi-transmitter Neural Ensembles

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Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 12948))

Abstract

A multitransmitter neural ensemble is a group of neurons interacting not via isolated synaptic connections, but via the emission of neurotransmitters directly into the shared extracellular space (ECS). There are multiple experimental evidence that non-synaptic interactions play the important role in biological neural circuits. We propose a model of multitransmitter neural ensembles where each neuron is represented as a finite state machine. An algorithm of neural interactions via the shared ECS is proposed. This framework allows one to capture the variety of spiking behavior observed in biological neurons. The model is intended primarily for simulation of simple neural ensembles where each neuron has a unique internal properties and plays the specific role in the ensemble activity. We show how the model can imitate such neural activity classes as tonic spiking, bursting, post-inhibitory rebound etc. To illustrate the key features of the proposed framework, we have modeled two examples of pattern-generating neural ensembles: a half-center oscillator and a feeding network of a pond snail.

The research was partially supported by the Russian Foundation for Basic Research (projects Nos. 19-04-00628, 20-07-00190).

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Acknowledgment

The author thanks Oleg Kuznetsov, Liudmila Zhilyakova, Varvara Dyakonova, and Dmitry Sakharov for helpful discussion on the mathematical framework and biological motivation.

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Authors and Affiliations

  1. V. A. Trapeznikov Institute of Control Sciences of the Russian Academy of Sciences, Moscow, Russia

    Nikolay Bazenkov

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  1. Nikolay Bazenkov
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Editors and Affiliations

  1. Rostov State Transport University, Rostov-on-Don, Russia

    Sergei M. Kovalev

  2. National Research University Higher School of Economics, Moscow, Russia

    Sergei O. Kuznetsov

  3. Russian Academy of Sciences, Moscow, Russia

    Aleksandr I. Panov

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Bazenkov, N. (2021). Heterogeneous Formal Neurons and Modeling of Multi-transmitter Neural Ensembles. In: Kovalev, S.M., Kuznetsov, S.O., Panov, A.I. (eds) Artificial Intelligence. RCAI 2021. Lecture Notes in Computer Science(), vol 12948. Springer, Cham. https://doi.org/10.1007/978-3-030-86855-0_1

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  • DOI: https://doi.org/10.1007/978-3-030-86855-0_1

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  • Print ISBN: 978-3-030-86854-3

  • Online ISBN: 978-3-030-86855-0

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