Abstract
Intracranial hemorrhage (ICH) is a dangerous condition of bleeding within the skull that calls for rapid and precise diagnosis due to potentially fatal consequences. In this paper, we propose Residual Segmentation with Generative Adversarial Networks (ReSGAN) to accurately localize the hemorrhage from computerized tomography (CT) scans with a GAN-based model. Although convolutional neural networks have shown success in the ICH segmentation task, precise localization remains challenging due to in-balance and scarcity of labeled training data. Synthetic samples from generative models, and aligned templates as reference from brain atlas have been demonstrated to alleviate the issues. We consider synthetic templates as another candidate and solve the problem by directly applying a generative model to segmentation. Our ReSGAN learns a distribution of pseudo-normal brain CT scans, that through residuals, reliably delineates the hemorrhaging areas. We perform experiments on two datasets and compare our model against a well established baseline, that consistently shows significant improvements, therefore demonstrating the validity of our novel method.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Antoniou, A., Storkey, A., Edwards, H.: Data augmentation generative adversarial networks. arXiv preprint arXiv:1711.04340 (2017)
Bhadauria, H., Singh, A., Dewal, M.: An integrated method for hemorrhage segmentation from brain CT imaging. Comput. Electric. Eng. 39(5), 1527–1536 (2013)
Frid-Adar, M., Diamant, I., Klang, E., Amitai, M., Goldberger, J., Greenspan, H.: Gan-based synthetic medical image augmentation for increased cnn performance in liver lesion classification. Neurocomputing 321, 321–331 (2018)
Goldberger, A.L., et al.: PhysioBank, PhysioToolkit, and PhysioNet: components of a new research resource for complex physiologic signals. Circulation 101(23), e215–e220 (2000). circulation Electronic Pages: http://circ.ahajournals.org/content/101/23/e215.full PMID:1085218, https://doi.org/10.1161/01.CIR.101.23.e215
Goodfellow, I., et al.: Generative adversarial nets. In: Advances in Neural Information Processing Systems, pp. 2672–2680 (2014)
Heusel, M., Ramsauer, H., Unterthiner, T., Nessler, B., Hochreiter, S.: Gans trained by a two time-scale update rule converge to a local nash equilibrium. In: Advances in Neural Information Processing Systems, pp. 6626–6637 (2017)
Hssayeni, M.: Computed tomography images for intracranial hemorrhage detection and segmentation (2020). https://doi.org/10.13026/4nae-zg36
Hssayeni, M.D., Croock, M.S., Salman, A.D., Al-khafaji, H.F., Yahya, Z.A., Ghoraani, B.: Intracranial hemorrhage segmentation using a deep convolutional model. Data 5(1), 14 (2020)
Johnson, J., Alahi, A., Fei-Fei, L.: Perceptual losses for real-time style transfer and super-resolution. In: Leibe, B., Matas, J., Sebe, N., Welling, M. (eds.) ECCV 2016. LNCS, vol. 9906, pp. 694–711. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46475-6_43
Kuo, W., Häne, C., Yuh, E., Mukherjee, P., Malik, J.: Patchfcn for intracranial hemorrhage detection. arXiv preprint arXiv:1806.03265 (2018)
Kwon, D., et al.: Siamese U-Net with healthy template for accurate segmentation of intracranial hemorrhage. In: Shen, D., et al. (eds.) MICCAI 2019. LNCS, vol. 11766, pp. 848–855. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32248-9_94
Park, T., Liu, M.Y., Wang, T.C., Zhu, J.Y.: Semantic image synthesis with spatially-adaptive normalization. In: Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition, pp. 2337–2346 (2019)
Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28
Salimans, T., Goodfellow, I., Zaremba, W., Cheung, V., Radford, A., Chen, X.: Improved techniques for training gans. In: Advances in Neural Information Processing Systems, pp. 2234–2242 (2016)
Sandfort, V., Yan, K., Pickhardt, P.J., Summers, R.M.: Data augmentation using generative adversarial networks (cyclegan) to improve generalizability in ct segmentation tasks. Sci. Rep. 9(1), 1–9 (2019)
Shin, H.C., et al.: Medical image synthesis for data augmentation and anonymization using generative adversarial networks. In: Gooya, A., Goksel, O., Oguz, I., Burgos, N. (eds.) SASHIMI 2018. LNCS, vol. 11037, pp. 1–11. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00536-8_1
Tan, Z., et al.: Efficient semantic image synthesis via class-adaptive normalization. IEEE Trans. Pattern Anal. Mach. Intell. (2021)
Tan, Z., et al.: Rethinking spatially-adaptive normalization. arXiv preprint arXiv:2004.02867 (2020)
Xi, G., Keep, R.F., Hoff, J.T.: Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol. 5(1), 53–63 (2006)
Acknowledgment
This work was supported by the National Research Foundation of Korea(NRF) grant funded by the Korea government(MSIT) (NRF-No. 2021R1A2C3011169)[30%], Electronics and Telecommunications Research Institute(ETRI) grant funded by the Korean government[21ZS1100, Core Technology Research for Self-Improving Integrated Artificial Intelligence System][30%], and the Industrial Strategic Technology Development Program(20011875, Development of AI based diagnostic technology for medical imaging devices) funded By the Ministry of Trade, Industry & Energy(MOTIE, Korea)[40%]
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
1 Electronic supplementary material
Below is the link to the electronic supplementary material.
Rights and permissions
Copyright information
© 2021 Springer Nature Switzerland AG
About this paper
Cite this paper
Toikkanen, M., Kwon, D., Lee, M. (2021). ReSGAN: Intracranial Hemorrhage Segmentation with Residuals of Synthetic Brain CT Scans. In: de Bruijne, M., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2021. MICCAI 2021. Lecture Notes in Computer Science(), vol 12901. Springer, Cham. https://doi.org/10.1007/978-3-030-87193-2_38
Download citation
DOI: https://doi.org/10.1007/978-3-030-87193-2_38
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-87192-5
Online ISBN: 978-3-030-87193-2
eBook Packages: Computer ScienceComputer Science (R0)