Abstract
Congenital hydronephrosis, which is the dilatation of the renal collecting system, is common in children, resolving in most and treatable in the remaining 25%. Sonography is routinely used for hydronephrosis detection and longitudinal evaluation but lacks standardization in acquisition and provides no information about kidney function. These facts make the visual assessment of hydronephrosis from ultrasound subjective and variable. In this paper, we present an automatic method to standardize the analysis of the kidney regions in sonograms for the quantification of hydronephrosis severity as well as the prediction of obstruction. First, the field-of-view in images is standardized by segmenting the kidney regions using convolutional neural networks and reorienting them along their longest axes in the coronal view. Then, the core areas of the kidney containing the pelvis and calyces are identified by correlation analysis. Each standardized kidney image slice is evaluated using a deep learning-based approach to predict the obstruction severity, and the slice-based predictive scores are fused based on a weighted-voting technique to determine the final risk score. The performance of the method was evaluated on 54 hydronephrotic kidneys with known clinical outcome. Results show that our method could automatically predict the obstruction severity with an average accuracy of 0.83, a significant improvement over the common clinical approach (p-value < 0.001). Our method has the potential to predict kidney function from routine ultrasound evaluation.
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References
Peters, C., Chevalier, R.L.: Congenital urinary obstruction: pathophysiology and clinical evaluation. In: Campbell-Walsh Textbook of Urology, 10th edn. Elsevier, Philadelphia (2012)
Cerrolaza, J.J., Safdar, N., Biggs, E., Jago, J., Peters, C.A., Linguraru, M.G.: Renal segmentation from 3D ultrasound via fuzzy appearance models and patient-specific alpha shapes. IEEE Trans. Med. Imaging 35(11), 2393–2402 (2016)
Fernbach, S.K., Maizels, M., Conway, J.J.: Ultrasound grading of hydronephrosis: introduction to the system used by the Society for Fetal Urology. Pediatr. Radiol. 23(6), 478–480 (1993)
Keays, M.A., et al.: Reliability assessment of society for fetal urology ultrasound grading system for hydronephrosis. J. Urol. 180(4), 1680–1683 (2008)
Koizumi, K., et al.: Japanese consensus guidelines for pediatric nuclear medicine: part 1: pediatric radiopharmaceutical administered doses (JSNM pediatric dosage card). Part 2: technical considerations for pediatric nuclear medicine imaging procedures. Ann. Nucl. Med. 28(5), 498–503 (2014)
Shapiro, S.R., Wahl, E.F., Silberstein, M.J., Steinhardt, G.: Hydronephrosis index: a new method to track patients with hydronephrosis quantitatively. Urology 72(3), 536–538 (2008)
Tabrizi, P.R., et al.: Automatic segmentation of the renal collecting system in 3D pediatric ultrasound to assess the severity of hydronephrosis. In: International Symposium on Biomedical Imaging, Venice, Italy, pp. 1717–1720. IEEE (2019)
Rickard, M., Lorenzo, A.J., Braga, L.H.: Renal parenchyma to hydronephrosis area ratio (PHAR) as a predictor of future surgical intervention for infants with high-grade prenatal hydronephrosis. Urology 101, 85–89 (2017)
Dhindsa, K., Smail, L.C., McGrath, M., Braga, L.H., Becker, S., Sonnadara, R.R.: Grading prenatal hydronephrosis from ultrasound imaging using deep convolutional neural networks. In: 15th Conference on Computer and Robot Vision, CRV, Toronto, ON, Canada, pp. 80–87. IEEE (2018)
Smail, L.C., Dhindsa, K., Braga, L.H., Becker, S., Sonnadara, R.R.: Using deep learning algorithms to grade hydronephrosis severity: toward a clinical adjunct. Front. Pediatr. 8(1), 1–8 (2020)
Cerrolaza, J.J., Peters, C.A., Martin, A.D., Myers, E., Safdar, N., Linguraru, M.G.: Quantitative ultrasound for measuring obstructive severity in children with hydronephrosis. J. Urol. 195(4), 1093–1099 (2016)
Xie, J., Jiang, Y., Tsui, H.T.: Segmentation of kidney from ultrasound images based on texture and shape priors. IEEE Trans. Med. Imaging 24(1), 45–57 (2005)
Mendoza, C.S., Kang, X., Safdar, N., Myers, E., Peters, C.A., Linguraru, M.G.: Kidney segmentation in ultrasound via genetic initialization and active shape models with rotation correction. In: International Symposium on Biomedical Imaging, San Francisco, CA, USA, pp. 69–72 (2013)
Ardon, R., Cuingnet, R., Bachuwar, K., Auvray, V.: Fast kidney detection and segmentation with learned kernel convolution and model deformation in 3D ultrasound images. In: International Symposium on Biomedical Imaging, New York, NY, USA, pp. 267–271. IEEE (2015)
Marsousi, M., Plataniotis, K.N., Stergiopoulos, S.: An automated approach for kidney segmentation in three-dimensional ultrasound images. IEEE J. Biomed. Heal. Informatics 21(4), 1079–1094 (2017)
Tabrizi, P.R., Mansoor, A., Cerrolaza, J.J., Jago, J., Linguraru, M.G.: Automatic kidney segmentation in 3D pediatric ultrasound images using deep neural networks and weighted fuzzy active shape model. In: International Symposium on Biomedical Imaging, Washington, DC, USA, pp. 1170–1173. IEEE (2018)
Ravishankar, H., Venkataramani, R., Thiruvenkadam, S., Sudhakar, P., Vaidya, V.: Learning and incorporating shape models for semantic segmentation. In: Descoteaux, M., Maier-Hein, L., Franz, A., Pierre Jannin, D., Collins, L., Duchesne, S. (eds.) MICCAI 2017. LNCS, vol. 10433, pp. 203–211. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-66182-7_24
Yin, S., et al.: Automatic kidney segmentation in ultrasound images using subsequent boundary distance regression and pixelwise classification networks. Med. Image Anal. 60, 101602 (2020)
Roshanitabrizi, P., et al.: Pediatric hydronephrosis severity assessment using convolutional neural networks with standardized ultrasound images. In: International Symposium on Biomedical Imaging, Nice, Acropolis, France. pp. 1803–1806. IEEE (2021)
Chaurasia, A., Culurciello, E.: LinkNet: exploiting encoder representations for efficient semantic segmentation. In: Visual Communications and Image Processing, St. Petersburg, FL, USA, pp. 1–5. IEEE (2017)
Yakubovskiy, P.: Segmentation Models. GitHub Repository. GitHub (2019)
Zhou, Z., Rahman Siddiquee, M.M., Tajbakhsh, N., Liang, J.: UNet++: redesigning skip connections to exploit multiscale features in image segmentation. IEEE Trans. Med. Imaging 39(6), 1856–1867 (2020)
Zhou, Z., Rahman Siddiquee, M.M., Tajbakhsh, N., Liang, J.: Unet++: a nested U-net architecture for medical image segmentation. In: Stoyanov, D., et al. (eds.) DLMIA/ML-CDS -2018. LNCS, vol. 11045, pp. 3–11. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00889-5_1
Pearson, K.: Mathematical contributions to the theory of evolution. III. Regression, heredity, and panmixia. Philos. Trans. R. Soc. London 187, 253–318 (1896)
LeCun, Y., Bottou, L., Bengio, Y., Haffner, P.: Gradient-based learning applied to document recognition. Proc. IEEE. 86(11), 2278–2323 (1998)
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Roshanitabrizi, P. et al. (2021). Standardized Analysis of Kidney Ultrasound Images for the Prediction of Pediatric Hydronephrosis Severity. In: Lian, C., Cao, X., Rekik, I., Xu, X., Yan, P. (eds) Machine Learning in Medical Imaging. MLMI 2021. Lecture Notes in Computer Science(), vol 12966. Springer, Cham. https://doi.org/10.1007/978-3-030-87589-3_38
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