Skip to main content

Self Supervised Contrastive Learning on Multiple Breast Modalities Boosts Classification Performance

  • Conference paper
  • First Online:
Predictive Intelligence in Medicine (PRIME 2021)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 12928))

Included in the following conference series:

Abstract

Medical imaging classification tasks require models that can provide high accuracy results. Training these models requires large annotated datasets. Such datasets are not openly available, are very costly, and annotations require professional knowledge in the medical domain. In the medical field specifically, datasets can also be inherently small. Self-supervised methods allow the construction of models that learn image representations on large unlabeled image sets; these models can then be fine-tuned on smaller datasets for various tasks. With breast cancer being a leading cause of death among women worldwide, precise lesion classification is crucial for detecting malignant cases. Through a set of experiments on 30K unlabeled mammography (MG) and ultrasound (US) breast images, we demonstrate a practical way to use self-supervised contrastive learning to improve breast cancer classification. Contrastive learning is a machine learning technique that teaches the model which data points are similar or different by using representations that force similar elements to be equal and dissimilar elements to be different. Our goal is to show the advantages of using self-supervised pre-training on a large unlabeled set, compared to training small sets from scratch. We compare training from scratch on small labeled MG and US datasets to using self-supervised contrastive methods and supervised pre-training. Our results demonstrate that the improvement in biopsy classification using self-supervision is consistent on both modalities. We show how to use self-supervised methods on medical data and propose a novel method of training contrastive learning on MG, which results in higher specificity classification.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Azizi, S., et al.: Big self-supervised models advance medical image classification. arXiv preprint arXiv:2101.05224 (2021)

  2. Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A., Jemal, A.: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: Cancer J. Clin. 68(6), 394–424 (2018)

    Google Scholar 

  3. Calli, E., Sogancioglu, E., Scholten, E.T., Murphy, K., van Ginneken, B.: Handling label noise through model confidence and uncertainty: application to chest radiograph classification. In: Mori, K., Hahn, H.K. (eds.) Medical Imaging 2019: Computer-Aided Diagnosis, vol. 10950, pp. 289–296. International Society for Optics and Photonics, SPIE (2019)

    Google Scholar 

  4. Chen, T., Kornblith, S., Norouzi, M., Hinton, G.: A simple framework for contrastive learning of visual representations. In: International Conference on Machine Learning, pp. 1597–1607. PMLR (2020)

    Google Scholar 

  5. Chen, X., Fan, H., Girshick, R., He, K.: Improved baselines with momentum contrastive learning. arXiv preprint arXiv:2003.04297 (2020)

  6. DeLong, E.R., DeLong, D.M., Clarke-Pearson, D.L.: Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 837–845 (1988)

    Google Scholar 

  7. Hadad, O., Bakalo, R., Ben-Ari, R., Hashoul, S., Amit, G.: Classification of breast lesions using cross-modal deep learning. In: 2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017), pp. 109–112. IEEE (2017)

    Google Scholar 

  8. He, K., Fan, H., Wu, Y., Xie, S., Girshick, R.: Momentum contrast for unsupervised visual representation learning. In: Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition, pp. 9729–9738 (2020)

    Google Scholar 

  9. He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 770–778 (2016)

    Google Scholar 

  10. Jamaludin, A., Kadir, T., Zisserman, A.: Self-supervised learning for spinal MRIs. In: Cardoso, M.J., et al. (eds.) DLMIA/ML-CDS -2017. LNCS, vol. 10553, pp. 294–302. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-67558-9_34

    Chapter  Google Scholar 

  11. Khan, S., Islam, N., Jan, Z., Din, I.U., Rodrigues, J.J.P.C.: A novel deep learning based framework for the detection and classification of breast cancer using transfer learning. Pattern Recogn. Lett. 125, 1–6 (2019)

    Article  Google Scholar 

  12. Lehman, C.D., Arao, R.F., et al.: National performance benchmarks for modern screening digital mammography: update from the breast cancer surveillance consortium. Radiology 283(1), 49–58 (2017)

    Article  Google Scholar 

  13. Li, Y., Zhang, Y., Zhu, Z.: Learning deep networks under noisy labels for remote sensing image scene classification. In: IGARSS 2019–2019 IEEE International Geoscience and Remote Sensing Symposium, pp. 3025–3028 (2019)

    Google Scholar 

  14. McKinney, S.M., et al.: International evaluation of an AI system for breast cancer screening. Nature 577(7788), 89–94 (2020)

    Article  Google Scholar 

  15. Oord, A.V.D., Li, Y., Vinyals, O.: Representation learning with contrastive predictive coding. arXiv preprint arXiv:1807.03748 (2018)

  16. Schaffter, T., et al.: Evaluation of combined artificial intelligence and radiologist assessment to interpret screening mammograms. JAMA Netw. Open 3(3), e200265–e200265 (2020)

    Article  Google Scholar 

  17. Shi, J., Zhou, S., Liu, X., Zhang, Q., Lu, M., Wang, T.: Stacked deep polynomial network based representation learning for tumor classification with small ultrasound image dataset. Neurocomputing 194, 87–94 (2016)

    Article  Google Scholar 

  18. Szegedy, C., Ioffe, S., et al.: Inception-v4, Inception-ResNet and the impact of residual connections on learning (2016)

    Google Scholar 

  19. Tabár, L., et al.: The incidence of fatal breast cancer measures the increased effectiveness of therapy in women participating in mammography screening. Cancer 125(4), 515–523 (2019)

    Article  Google Scholar 

  20. Zeimarani, B., Costa, M.G.F., Nurani, N.Z., Bianco, S.R., De Albuquerque Pereira, W.C., Filho, C.F.F.C.: Breast lesion classification in ultrasound images using deep convolutional neural network. IEEE Access 8, 133349–133359 (2020). https://doi.org/10.1109/ACCESS.2020.3010863

  21. Zhang, X., et al.: Whole mammogram image classification with convolutional neural networks. In: 2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), pp. 700–704 (2017)

    Google Scholar 

  22. Zhou, H.-Y., Yu, S., Bian, C., Hu, Y., Ma, K., Zheng, Y.: Comparing to learn: surpassing ImageNet pretraining on radiographs by comparing image representations. In: Martel, A.L., et al. (eds.) MICCAI 2020. LNCS, vol. 12261, pp. 398–407. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-59710-8_39

    Chapter  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shaked Perek .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Perek, S., Amit, M., Hexter, E. (2021). Self Supervised Contrastive Learning on Multiple Breast Modalities Boosts Classification Performance. In: Rekik, I., Adeli, E., Park, S.H., Schnabel, J. (eds) Predictive Intelligence in Medicine. PRIME 2021. Lecture Notes in Computer Science(), vol 12928. Springer, Cham. https://doi.org/10.1007/978-3-030-87602-9_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-87602-9_11

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-87601-2

  • Online ISBN: 978-3-030-87602-9

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics