Abstract
In March 2020 the WHO announced the pandemic due to the new coronavirus nCoV-19, which uses the ACE-2 enzyme, present in several body tissues, to infect the host. The presence of ACE-2 in the corneal limbus makes the eyeball an important route of infection for the virus, which is why corneal transplantation is precluded in cases of suspected COVID-19 donors. Also in 2020, The Global Alliance of Eye Bank Association (GAEBA) developed restrictive measures aimed at preventing the spread of the new coronavirus between eye tissue donors and recipient patients, consequently, there was a reduction in effective donors and a global increase in the waiting lines for corneal transplantation worldwide. On the other hand, artificial corneal implantation presents itself as a positive alternative for the current moment, since it makes it impossible for the donor and the recipient of the eye tissue to become infected. In this sense, the present study aims to describe the use of artificial corneas in keratoplasties, considering this a safe and effective method for restoring vision during the COVID-19 pandemic.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Sohrabi, C., et al.: World Health Organization declares global emergency: a review of the 2019 novel coronavirus (COVID-19). Int. J. Surg. 76, 71–76 (2020)
Morales, A.J.R., et al.: Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis. Travel Med. Infect. Dis. 34, 1–13 (2020)
Lake, M.A.: What we know so far: COVID-19 current clinical knowledge and research. Clin. Med. 17(6), 124–128 (2020)
Yoshimoto, F.K.: The proteins of severe acute respiratory syndrome Coronavirus-2 (SARS CoV-2 or n-COV19), the cause of COVID-19. Protein J. 39(3), 198–216 (2020). https://doi.org/10.1007/s10930-020-09901-4
Lana, R.M., et al.: The novel coronavirus (SARS-CoV-2) emergency and the role of timely and effective national health surveillance. Cad Saude Publica 36(3), e00019620 (2020)
Tortorici, M.A., Veesler, D.: Structural insights into coronavirus entry. Adv. Virus Res. 105, 93–116 (2019). https://doi.org/10.1016/bs.aivir.2019.08.002
Scialo, F., et al.: ACE2: the major cell entry receptor for SARS-CoV-2. Lung 198(6), 867–877 (2020). https://doi.org/10.1007/s00408-020-00408-4
Bourgonje, A.R., et al.: Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19). J. Pathol. 251(3), 228–248 (2020). https://doi.org/10.1002/path.5471
Torres, B.R.S., Cunha, C.E.X., Castro, L.R., Brito, P.L.M., Ferreira, C.V.O., Ribeiro, M.V.M.R.: Ocular manifestations of COVID-19: a literature review. Revista da Associação Médica Brasileira 66(9), 1296–1300 (2020). https://doi.org/10.1590/1806-9282.66.9.1296
Global Alliance of Eye Bank Associations. ALERT UP-DATE: Coronavirus (COVID-2019) and Ocular Tissue Donation. http://www.gaebaorg/2020/alert-coronavirus-2019-ncov-and-ocular-tissue-donation. Accessed 18 Apr 2020
Ang, M., Moriyama, A., Colby, K., et al.: Corneal transplantation in the aftermath of the COVID-19 pandemic: an international perspective. Br. J. Ophthalmol. 104(11), 1477–1481 (2020). https://doi.org/10.1136/bjophthalmol-2020-317013
Polisetti, N., Islam, M.M., Griffith, M.: The artificial cornea. Methods Mol. Biol. 1014, 45–52 (2013). https://doi.org/10.1007/978-1-62703-432-6_2
Almeida, H.G.: Transplante de córnea no Brasil: progresso e dificuldades em 16 anos. Orientador: Newton Kara José Junior. 83 f. Tese (Doutorado) – Faculdade de Medicina da Universidade de São Paulo, São Paulo (2018)
Ple-Pakon, P.A., Shtein, R.M.: Trends in corneal transplantation: indications and techniques. Curr. Opin. Ophthalmol. 25, 300–305 (2014)
Mathews, P.M., Lindsley, K., Aldave, A.J., Akpek, E.K.: Etiology of global corneal blindness and current practices of corneal transplantation: a focused review. Cornea 37(9), 1198–1203 (2018). https://doi.org/10.1097/ICO.0000000000001666
Boynton, G.E., Woodward, M.A.: Evolving techniques in corneal transplantation. Curr. Surg. Rep. 3(2), 1–8 (2014). https://doi.org/10.1007/s40137-014-0079-5
Wang, J., Li, X., Cao, G., Wu, X., Wang, Z., Yan, T.: COVID-19 in a kidney transplant patient. Eur. Urol. 77(6), 769–770 (2020)
Nacif, L.S., et al.: COVID-19 in solid organ transplantation patients: a systematic review. Clinics (Sao Paulo) 75, e1983 (2020). https://doi.org/10.6061/clinics/2020/e1983
Ali, M.J.: The SARS-CoV-2, tears, and ocular surface debate: what we know and what we need to know. Indian J. Ophthalmol. 68(7), 1245–1246 (2020). https://doi.org/10.4103/ijo.IJO_1881_20
Cho, P., Boost, M.: COVID 19 – an eye on the virus. Cont. Lens Anterior Eye 43(4), 313–314 (2020). https://doi.org/10.1016/j.clae.2020.05.011
Chaurasia, S., Sharma, N., Das, S.: COVID-19 and eye banking. Indian J. Ophthalmol. 68(6), 1215–1216 (2020). https://doi.org/10.4103/ijo.IJO_1033_20
CorNeat [Internet]. CorNeat EverPatch. https://www.corneat.com/corneat-everpatch-for-physicians (2021). Cited 24 May 2021
Alzahrani, K., et al.: Corneal clarity measurements in healthy volunteers across different age groups. Medicine 96(46), 1–6 (2017)
Bachmann, B.O., Keratin, S.S.: Kollagen oder doch Spendergewebe – wo liegt die Zukunft in der Entwicklung neuer Biomaterialien zur Hornhautrekonstruktion? [Biomaterials or donor tissue – what is the future of tissue engineering for cornea reconstruction?]. Klin. Monbl. Augenheilkd. 234(6), 758–762 (2017). https://doi.org/10.1055/s-0043-109024. German
Bradley, J.C., Hernandez, E.G., Schawb, I.R., Mannis, M.J.: Boston type I keratoprosthesis: the University of California Davis experience. Cornea 28(3), 321–327 (2009)
Kim, M.J., Yu, F., Aldave, A.J.: Microbial keratitis after Boston type I keratoprosthesis implantation: incidence, organisms, risk factors, and outcomes. Ophthalmology 120(11), 2209–2216 (2013)
Saeed, H.N., Shanbhag, S., Chodosh, J.: The Boston keratoprosthesis. Curr. Opin. Ophthalmol. 28(4), 390–396 (2017). https://doi.org/10.1097/ICU.0000000000000373
Zarei-Ghanavati, M., Avadhanam, V., Vasquez Perez, A., Liu, C.: The osteo-odonto-keratoprosthesis. Curr. Opin. Ophthalmol. 28(4), 397–402 (2017). https://doi.org/10.1097/ICU.0000000000000388
Kwitko, Sérgio e Stolz, Andressa Prestes Ceratoprótese de Boston. Revista Brasileira de Oftalmologia 71(6), 403–406 (2012). Acessado 12 Junho 2021. Epub 04 Jan 2013. ISSN 1982-8551. https://doi.org/10.1590/S0034-72802012000600014
Harissi-Dagher, M., Slim, E.: La kératoprothèse de Boston type 1 [Boston keratoprosthesis type 1]. J. Fr. Ophtalmol. 42(3), 295–302 (2019). https://doi.org/10.1016/j.jfo.2018.08.010. French
Xie, R.Z., Stretton, S., Sweeney, D.F.: Artificial cornea: towards a synthetic only for correction of refractive error. Biosci. Rep. 21(4), 513–536 (2001). https://doi.org/10.1023/a:1017900111663
Griffith, M., et al.: Biosynthetic alternatives for corneal transplant surgery. Expert Rev. Ophthalmol. 15(3), 129–143 (2020). https://doi.org/10.1080/17469899.2020.1754798
Griffith, M., et al.: Biosynthetic alternatives for corneal transplant surgery. Expert Rev. Ophthalmol. (2020). https://doi.org/10.1080/17469899.2020.1754798
Zhang, B., et al.: 3D bioprinting for artificial cornea: challenges and perspectives. Med. Eng. Phys. 71, 68–78 (2019). https://doi.org/10.1016/j.medengphy.2019.05.002
Hos, D., Matthaei, M., Bock, F., et al.: Immune reactions after modern lamellar (DALK, DSAEK, DMEK) versus conventional penetrating corneal transplantation. Prog. Retin. Eye Res. 73, 100768 (2019). https://doi.org/10.1016/j.preteyeres.2019.07.001
Cruz, G.K.P., Ferreira-Júnior, M.A., Azevedo, I.C., Santos, V.E.P., Flores, V.G.T., Gonçalves, E.A.P.: Clinical and surgical factors and intraoperative complications in patients who underwent penetrating keratoplasty. Rev. Latino-Am. Enfermagem. 27, e3141 (2019). https://doi.org/10.1590/1518-8345.2733-314
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Switzerland AG
About this paper
Cite this paper
da Cunha, C.E.X. et al. (2021). Artificial Corneal Transplantation and the Safe Recovery of Vision in the COVID-19 Pandemic. In: Rojas, I., Castillo-Secilla, D., Herrera, L.J., Pomares, H. (eds) Bioengineering and Biomedical Signal and Image Processing. BIOMESIP 2021. Lecture Notes in Computer Science(), vol 12940. Springer, Cham. https://doi.org/10.1007/978-3-030-88163-4_30
Download citation
DOI: https://doi.org/10.1007/978-3-030-88163-4_30
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-88162-7
Online ISBN: 978-3-030-88163-4
eBook Packages: Computer ScienceComputer Science (R0)