Skip to main content

Artificial Corneal Transplantation and the Safe Recovery of Vision in the COVID-19 Pandemic

  • Conference paper
  • First Online:
Bioengineering and Biomedical Signal and Image Processing (BIOMESIP 2021)

Abstract

In March 2020 the WHO announced the pandemic due to the new coronavirus nCoV-19, which uses the ACE-2 enzyme, present in several body tissues, to infect the host. The presence of ACE-2 in the corneal limbus makes the eyeball an important route of infection for the virus, which is why corneal transplantation is precluded in cases of suspected COVID-19 donors. Also in 2020, The Global Alliance of Eye Bank Association (GAEBA) developed restrictive measures aimed at preventing the spread of the new coronavirus between eye tissue donors and recipient patients, consequently, there was a reduction in effective donors and a global increase in the waiting lines for corneal transplantation worldwide. On the other hand, artificial corneal implantation presents itself as a positive alternative for the current moment, since it makes it impossible for the donor and the recipient of the eye tissue to become infected. In this sense, the present study aims to describe the use of artificial corneas in keratoplasties, considering this a safe and effective method for restoring vision during the COVID-19 pandemic.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Sohrabi, C., et al.: World Health Organization declares global emergency: a review of the 2019 novel coronavirus (COVID-19). Int. J. Surg. 76, 71–76 (2020)

    Article  Google Scholar 

  2. Morales, A.J.R., et al.: Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis. Travel Med. Infect. Dis. 34, 1–13 (2020)

    Google Scholar 

  3. Lake, M.A.: What we know so far: COVID-19 current clinical knowledge and research. Clin. Med. 17(6), 124–128 (2020)

    Article  Google Scholar 

  4. Yoshimoto, F.K.: The proteins of severe acute respiratory syndrome Coronavirus-2 (SARS CoV-2 or n-COV19), the cause of COVID-19. Protein J. 39(3), 198–216 (2020). https://doi.org/10.1007/s10930-020-09901-4

    Article  Google Scholar 

  5. Lana, R.M., et al.: The novel coronavirus (SARS-CoV-2) emergency and the role of timely and effective national health surveillance. Cad Saude Publica 36(3), e00019620 (2020)

    Article  Google Scholar 

  6. Tortorici, M.A., Veesler, D.: Structural insights into coronavirus entry. Adv. Virus Res. 105, 93–116 (2019). https://doi.org/10.1016/bs.aivir.2019.08.002

    Article  Google Scholar 

  7. Scialo, F., et al.: ACE2: the major cell entry receptor for SARS-CoV-2. Lung 198(6), 867–877 (2020). https://doi.org/10.1007/s00408-020-00408-4

    Article  Google Scholar 

  8. Bourgonje, A.R., et al.: Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19). J. Pathol. 251(3), 228–248 (2020). https://doi.org/10.1002/path.5471

    Article  Google Scholar 

  9. Torres, B.R.S., Cunha, C.E.X., Castro, L.R., Brito, P.L.M., Ferreira, C.V.O., Ribeiro, M.V.M.R.: Ocular manifestations of COVID-19: a literature review. Revista da Associação Médica Brasileira 66(9), 1296–1300 (2020). https://doi.org/10.1590/1806-9282.66.9.1296

    Article  Google Scholar 

  10. Global Alliance of Eye Bank Associations. ALERT UP-DATE: Coronavirus (COVID-2019) and Ocular Tissue Donation. http://www.gaebaorg/2020/alert-coronavirus-2019-ncov-and-ocular-tissue-donation. Accessed 18 Apr 2020

  11. Ang, M., Moriyama, A., Colby, K., et al.: Corneal transplantation in the aftermath of the COVID-19 pandemic: an international perspective. Br. J. Ophthalmol. 104(11), 1477–1481 (2020). https://doi.org/10.1136/bjophthalmol-2020-317013

    Article  Google Scholar 

  12. Polisetti, N., Islam, M.M., Griffith, M.: The artificial cornea. Methods Mol. Biol. 1014, 45–52 (2013). https://doi.org/10.1007/978-1-62703-432-6_2

    Article  Google Scholar 

  13. Almeida, H.G.: Transplante de córnea no Brasil: progresso e dificuldades em 16 anos. Orientador: Newton Kara José Junior. 83 f. Tese (Doutorado) – Faculdade de Medicina da Universidade de São Paulo, São Paulo (2018)

    Google Scholar 

  14. Ple-Pakon, P.A., Shtein, R.M.: Trends in corneal transplantation: indications and techniques. Curr. Opin. Ophthalmol. 25, 300–305 (2014)

    Article  Google Scholar 

  15. Mathews, P.M., Lindsley, K., Aldave, A.J., Akpek, E.K.: Etiology of global corneal blindness and current practices of corneal transplantation: a focused review. Cornea 37(9), 1198–1203 (2018). https://doi.org/10.1097/ICO.0000000000001666

    Article  Google Scholar 

  16. Boynton, G.E., Woodward, M.A.: Evolving techniques in corneal transplantation. Curr. Surg. Rep. 3(2), 1–8 (2014). https://doi.org/10.1007/s40137-014-0079-5

    Article  Google Scholar 

  17. Wang, J., Li, X., Cao, G., Wu, X., Wang, Z., Yan, T.: COVID-19 in a kidney transplant patient. Eur. Urol. 77(6), 769–770 (2020)

    Article  Google Scholar 

  18. Nacif, L.S., et al.: COVID-19 in solid organ transplantation patients: a systematic review. Clinics (Sao Paulo) 75, e1983 (2020). https://doi.org/10.6061/clinics/2020/e1983

    Article  Google Scholar 

  19. Ali, M.J.: The SARS-CoV-2, tears, and ocular surface debate: what we know and what we need to know. Indian J. Ophthalmol. 68(7), 1245–1246 (2020). https://doi.org/10.4103/ijo.IJO_1881_20

    Article  Google Scholar 

  20. Cho, P., Boost, M.: COVID 19 – an eye on the virus. Cont. Lens Anterior Eye 43(4), 313–314 (2020). https://doi.org/10.1016/j.clae.2020.05.011

    Article  Google Scholar 

  21. Chaurasia, S., Sharma, N., Das, S.: COVID-19 and eye banking. Indian J. Ophthalmol. 68(6), 1215–1216 (2020). https://doi.org/10.4103/ijo.IJO_1033_20

    Article  Google Scholar 

  22. CorNeat [Internet]. CorNeat EverPatch. https://www.corneat.com/corneat-everpatch-for-physicians (2021). Cited 24 May 2021

  23. Alzahrani, K., et al.: Corneal clarity measurements in healthy volunteers across different age groups. Medicine 96(46), 1–6 (2017)

    Article  Google Scholar 

  24. Bachmann, B.O., Keratin, S.S.: Kollagen oder doch Spendergewebe – wo liegt die Zukunft in der Entwicklung neuer Biomaterialien zur Hornhautrekonstruktion? [Biomaterials or donor tissue – what is the future of tissue engineering for cornea reconstruction?]. Klin. Monbl. Augenheilkd. 234(6), 758–762 (2017). https://doi.org/10.1055/s-0043-109024. German

    Article  Google Scholar 

  25. Bradley, J.C., Hernandez, E.G., Schawb, I.R., Mannis, M.J.: Boston type I keratoprosthesis: the University of California Davis experience. Cornea 28(3), 321–327 (2009)

    Article  Google Scholar 

  26. Kim, M.J., Yu, F., Aldave, A.J.: Microbial keratitis after Boston type I keratoprosthesis implantation: incidence, organisms, risk factors, and outcomes. Ophthalmology 120(11), 2209–2216 (2013)

    Article  Google Scholar 

  27. Saeed, H.N., Shanbhag, S., Chodosh, J.: The Boston keratoprosthesis. Curr. Opin. Ophthalmol. 28(4), 390–396 (2017). https://doi.org/10.1097/ICU.0000000000000373

    Article  Google Scholar 

  28. Zarei-Ghanavati, M., Avadhanam, V., Vasquez Perez, A., Liu, C.: The osteo-odonto-keratoprosthesis. Curr. Opin. Ophthalmol. 28(4), 397–402 (2017). https://doi.org/10.1097/ICU.0000000000000388

    Article  Google Scholar 

  29. Kwitko, Sérgio e Stolz, Andressa Prestes Ceratoprótese de Boston. Revista Brasileira de Oftalmologia 71(6), 403–406 (2012). Acessado 12 Junho 2021. Epub 04 Jan 2013. ISSN 1982-8551. https://doi.org/10.1590/S0034-72802012000600014

  30. Harissi-Dagher, M., Slim, E.: La kératoprothèse de Boston type 1 [Boston keratoprosthesis type 1]. J. Fr. Ophtalmol. 42(3), 295–302 (2019). https://doi.org/10.1016/j.jfo.2018.08.010. French

    Article  Google Scholar 

  31. Xie, R.Z., Stretton, S., Sweeney, D.F.: Artificial cornea: towards a synthetic only for correction of refractive error. Biosci. Rep. 21(4), 513–536 (2001). https://doi.org/10.1023/a:1017900111663

    Article  Google Scholar 

  32. Griffith, M., et al.: Biosynthetic alternatives for corneal transplant surgery. Expert Rev. Ophthalmol. 15(3), 129–143 (2020). https://doi.org/10.1080/17469899.2020.1754798

    Article  Google Scholar 

  33. Griffith, M., et al.: Biosynthetic alternatives for corneal transplant surgery. Expert Rev. Ophthalmol. (2020). https://doi.org/10.1080/17469899.2020.1754798

    Article  Google Scholar 

  34. Zhang, B., et al.: 3D bioprinting for artificial cornea: challenges and perspectives. Med. Eng. Phys. 71, 68–78 (2019). https://doi.org/10.1016/j.medengphy.2019.05.002

    Article  Google Scholar 

  35. Hos, D., Matthaei, M., Bock, F., et al.: Immune reactions after modern lamellar (DALK, DSAEK, DMEK) versus conventional penetrating corneal transplantation. Prog. Retin. Eye Res. 73, 100768 (2019). https://doi.org/10.1016/j.preteyeres.2019.07.001

    Article  Google Scholar 

  36. Cruz, G.K.P., Ferreira-Júnior, M.A., Azevedo, I.C., Santos, V.E.P., Flores, V.G.T., Gonçalves, E.A.P.: Clinical and surgical factors and intraoperative complications in patients who underwent penetrating keratoplasty. Rev. Latino-Am. Enfermagem. 27, e3141 (2019). https://doi.org/10.1590/1518-8345.2733-314

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

da Cunha, C.E.X. et al. (2021). Artificial Corneal Transplantation and the Safe Recovery of Vision in the COVID-19 Pandemic. In: Rojas, I., Castillo-Secilla, D., Herrera, L.J., Pomares, H. (eds) Bioengineering and Biomedical Signal and Image Processing. BIOMESIP 2021. Lecture Notes in Computer Science(), vol 12940. Springer, Cham. https://doi.org/10.1007/978-3-030-88163-4_30

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-88163-4_30

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-88162-7

  • Online ISBN: 978-3-030-88163-4

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics