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International Work-Conference on Bioinformatics and Biomedical Engineering

IWBBIO 2022: Bioinformatics and Biomedical Engineering pp 119–132Cite as

Design of an Analysis Method for the Human Cornea’s Bilateral Symmetry. A Case-Study in Healthy Patients

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Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 13346))

Abstract

Bilateral symmetry in the human body is a necessary feature for our body to function more efficiently. Apparently, it could be thought that the ocular structure presents a bilateral symmetrical structure, however this does not occur in all cases, especially in those that are pathological. In many cases, symmetry is essential for the achievement of certain optical tasks. This study presents a method for evaluating bilateral symmetry (direct vs mirror) from the differences between the Cartesian coordinates (OD vs OS) in healthy corneas using customized patient-specific models and unprocessed data from corneal tomographs. The results obtained in the central and paracentral regions of the corneas evaluated show that the bilateral mirror symmetry presents differences below 10 microns and the direct bilateral symmetry reaches differences of the order of 30 microns at spatial coordinates level. This study shows that the level of asymmetry in healthy corneas can be evaluated by direct or mirror symmetry, and that the presence of asymmetric anomalies can be useful as a clinical diagnostic tool.

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Funding

This publication was carried out within the framework of the project “Desarrollo y validación de un nuevo concepto de caracterización biomecánica-morfofuncional de la córnea” reference number DTS21/00103. This Project has been funded by Instituto de Salud Carlos III (ISCIII) and cofunded by the European Union.

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Authors and Affiliations

  1. Department of Structures, Construction and Graphic Expression, Technical University of Cartagena, 30202, Cartagena, Spain

    Francisco Cavas, José S. Velázquez & Francisco L. Sáez-Gutiérrez

  2. International School of Doctorate, Technical University of Cartagena, 30202, Cartagena, Spain

    Carmelo Gómez & Jorge Mira

  3. Keratoconus Unit of Vissum Corporation Alicante, 03016, Alicante, Spain

    Jorge Alió

Authors
  1. Francisco Cavas
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  2. José S. Velázquez
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  3. Carmelo Gómez
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  4. Jorge Mira
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  5. Francisco L. Sáez-Gutiérrez
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  6. Jorge Alió
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Corresponding author

Correspondence to Francisco Cavas .

Editor information

Editors and Affiliations

  1. Marcelina Siebold Guest Relations Dept., University of Granada, Granada, Spain

    Ignacio Rojas

  2. Faculty of Sciences, University of Granada, Granada, Spain

    Olga Valenzuela

  3. ETSIIT. CITIC-UGR, University of Granada, Granada, Spain

    Fernando Rojas

  4. ETSIIT, University of Granada, Granada, Spain

    Luis Javier Herrera

  5. University of Granada, Granada, Spain

    Francisco Ortuño

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Cavas, F., Velázquez, J.S., Gómez, C., Mira, J., Sáez-Gutiérrez, F.L., Alió, J. (2022). Design of an Analysis Method for the Human Cornea’s Bilateral Symmetry. A Case-Study in Healthy Patients. In: Rojas, I., Valenzuela, O., Rojas, F., Herrera, L.J., Ortuño, F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2022. Lecture Notes in Computer Science(), vol 13346. Springer, Cham. https://doi.org/10.1007/978-3-031-07704-3_10

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  • DOI: https://doi.org/10.1007/978-3-031-07704-3_10

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-07703-6

  • Online ISBN: 978-3-031-07704-3

  • eBook Packages: Computer ScienceComputer Science (R0)

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