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International Work-Conference on Bioinformatics and Biomedical Engineering

IWBBIO 2022: Bioinformatics and Biomedical Engineering pp 216–226Cite as

Modern Approaches to Cancer Treatment

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Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 13346))

Abstract

Cancer remains the most common worldwide problem with the highest impact on global health. It is the second leading cause of death, due to the lack of early diagnosis and high recurrence rate after conventional therapies. Although every year several new therapeutic approaches are proposed the urgent need for more effective therapeutic strategies to improve the survival rate and life expectancy of cancer patients rapidly grows.

A recent promising anticancer strategy is based on multinuclear heterocycles as widely investigated bioactive molecules, considered important synthetic targets for the development of novel therapeutic agents. Many nitrogen heterocycles are known for a long time as natural alkaloids, known to possess the broad and diverse biological activity and medicinal applicability. Nowadays however novel multinuclear drug-like heterocyclic structures are generated by methods of artificial intelligence. Novel approaches are required as more expeditious ways of studying their biological activity, capable of more than explaining their activity, and even prognosticating it.

This study highlights our and other authors’ recent results on the biological activity of multinuclear heterocyclic molecules on cancer cells, explicitly based on their capacity to bind to G-quadruplexes. It further stresses the need for novel G-quadruplex binding compounds, with elucidated biochemical mechanisms of action for biomedical applications, namely in anticancer therapies.

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Acknowledgements

This work has been supported by Grant Number DN 19/11 of 10.12. 2017 from the National Science Fund of Bulgaria. We also acknowledge the provided access to the e-infrastructure of the NCHDC – part of the Bulgarian National Roadmap on RIs, with the financial support by the Grant No D01-387/18.12.2020.

Author information

Authors and Affiliations

  1. Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

    Snezhana M. Bakalova & Jose Kaneti

  2. Institute of Molecular Biology “Acad. R. Tsanev”, Bulgarian Academy of Sciences, Sofia, 1113, Bulgaria

    Milena Georgieva

Authors
  1. Snezhana M. Bakalova
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  2. Milena Georgieva
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  3. Jose Kaneti
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Corresponding author

Correspondence to Milena Georgieva .

Editor information

Editors and Affiliations

  1. Marcelina Siebold Guest Relations Dept., University of Granada, Granada, Spain

    Ignacio Rojas

  2. Faculty of Sciences, University of Granada, Granada, Spain

    Olga Valenzuela

  3. ETSIIT. CITIC-UGR, University of Granada, Granada, Spain

    Fernando Rojas

  4. ETSIIT, University of Granada, Granada, Spain

    Luis Javier Herrera

  5. University of Granada, Granada, Spain

    Francisco Ortuño

Websites:

Websites:

https://www.who.int/health-topics/cancer

https://www.who.int/health

https://apps.who.int/gb/ebwha/pdf_files/WHA70/A70_R12-en.pdf

https://otavachemicals.com/products/targeted-libraries-and-focused-libraries

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Bakalova, S.M., Georgieva, M., Kaneti, J. (2022). Modern Approaches to Cancer Treatment. In: Rojas, I., Valenzuela, O., Rojas, F., Herrera, L.J., Ortuño, F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2022. Lecture Notes in Computer Science(), vol 13346. Springer, Cham. https://doi.org/10.1007/978-3-031-07704-3_18

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  • DOI: https://doi.org/10.1007/978-3-031-07704-3_18

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-07703-6

  • Online ISBN: 978-3-031-07704-3

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