Abstract
Micro-objects to aggregate at a specific location becomes a necessity when the concentration of micro-objects needs to be increased in the local area, such as in lab-on-a-chip devices. However, efficient aggregation is still a big challenge when detecting low concentrations of specimens on manipulation chips. Here, we present an acoustic manipulation chip containing artificial reflector to enhance the aggregation effect. To integrate with the traditional acoustic manipulation chips, V-shaped reflector is introduced into the microchannel as a solid vibration isolator to isolate acoustic waves in a liquid environment. When the V-shaped reflector is immersed into the sample contained in the microchannel to a certain depth, the activation of the piezoelectric transducer will produce acoustic oscillation of the substrate and localized acoustic streaming around the tip of the reflector. Under the localized acoustic streaming, micro-objects in the working area of the acoustic manipulation chip gather beneath reflector. Experimental results illustrate the proposed acoustic chip coupled with the V-shaped reflector offers an effective aggregation strategy for micro-objects, which has broad application prospects in the field of micro-manipulation.
This work was supported by the National Natural Science Foundation of China (No. 51975278), Research Fund of State Key Laboratory of Mechanics and Control of Mechanical Structures (Nanjing University of Aeronautics and Astronautics) (Grant No.MCMS-I-0321G01) and Fundamental Research Funds for the Central Universities (No. xcxjh20210103).
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Ou, H., Lu, X., Wei, Y., Zhao, C., Bao, J. (2022). A Novel Acoustic Manipulation Chip with V-shaped Reflector for Effective Aggregation of Micro-objects. In: Liu, H., et al. Intelligent Robotics and Applications. ICIRA 2022. Lecture Notes in Computer Science(), vol 13456. Springer, Cham. https://doi.org/10.1007/978-3-031-13822-5_53
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DOI: https://doi.org/10.1007/978-3-031-13822-5_53
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