Abstract
We presented a novel radiomics approach using multimodality MRI to predict the expression of an oncogene (O6-Methylguanine-DNA methyltransferase, MGMT) and overall survival (OS) of glioblastoma (GBM) patients. Specifically, we employed an EffNetV2-T, which was down scaled and modified from EfficientNetV2, as the feature extractor. Besides, we used evidential layers based to control the distribution of prediction outputs. The evidential layers help to classify the high-dimensional radiomics features to predict the methylation status of MGMT and OS. Tests showed that our model achieved an accuracy of 0.844, making it possible to use as a clinic-enabling technique in the diagnosing and management of GBM. Comparison results indicated that our method performed better than existing work.
X. Gu and X. Xu were partially supported by NIH R01LM012434. X. Gu was partially supported by NSF 2115095, NSF 1762287, NIH 92025.
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Feng, Y., Wang, J., An, D., Gu, X., Xu, X., Zhang, M. (2022). End-to-End Evidential-Efficient Net for Radiomics Analysis of Brain MRI to Predict Oncogene Expression and Overall Survival. In: Wang, L., Dou, Q., Fletcher, P.T., Speidel, S., Li, S. (eds) Medical Image Computing and Computer Assisted Intervention – MICCAI 2022. MICCAI 2022. Lecture Notes in Computer Science, vol 13433. Springer, Cham. https://doi.org/10.1007/978-3-031-16437-8_27
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