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Multilayer Cluster Heat Map Visualizing Biological Tensor Data

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Abstract

Recent advances in biological high-throughput technology are generating a broad range of omics data. Facing a torrent of massive biological data, visual data mining can be considered an intuitive and powerful approach for hypothesis generation. The cluster heat map approach has been popularly used to visualize the matrix types of biological data. In this study, we extended the use of the cluster heat map to reveal informative patterns hidden in third-order tensor-type biological data. By applying the extended method, a multilayer cluster heat map, to trans-omics and network tensor data, we successfully demonstrated the proof-of-concept of our approach. Our new visual data mining method will be a useful tool for increasing the amount of biological tensor data. Our implementation and the tensor data studied are available from http://www.hgc.jp/~niiyan/MCHM.

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References

  1. Wilkinson, L., Friendly, L.: The history of the cluster heat map. The American Statistician 63, 179–184 (2009)

    Article  MathSciNet  Google Scholar 

  2. Eisen, M., Spellman, P., Brown, P., Botstein, D.: Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. U. S. A. 95, 14863–14868 (1998)

    Article  Google Scholar 

  3. Rosenbloom, K., Dreszer, T., Long, J., Malladi, V., Sloan, C., Raney, B., Cline, M., Karolchik, D., Barber, G., Clawson, H., Diekhans, M., Fujita, P., Goldman, M., Gravell, R., Harte, R., Hinrichs, A., Kirkup, V., Kuhn, R., Learned, K., Maddren, M., Meyer, L., Pohl, A., Rhead, B., Wong, M., Zweig, A., Haussler, D., Kent, W.: ENCODE whole-genome data in the UCSC Genome Browser: update 2012. Nucleic Acids Res. 40, D912–D917 (2012)

    Google Scholar 

  4. Noushmehr, H., Weisenberger, D., Diefes, K., Phillips, H., Pujara, K., Berman, B., Pan, F., Pelloski, C., Sulman, E., Bhat, K., Verhaak, R., Hoadley, K., Hayes, D., Perou, C., Schmidt, H., Ding, L., Wilson, R., Van Den Berg, D., Shen, H., Bengtsson, H., Neuvial, P., Cope, L., Buckley, J., Herman, J., Baylin, S., Laird, P., Aldape, K.: Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 17, 510–522 (2010)

    Article  Google Scholar 

  5. Li, W., Liu, C., Zhang, T., Li, H., Waterman, M., Zhou, X.: Integrative analysis of many weighted co-expression networks using tensor computation. PLoS Comput. Biol. 7, e1001106 (2011)

    Google Scholar 

  6. Omberg, L., Golub, G., Alter, O.: A tensor higher-order singular value decomposition for integrative analysis of DNA microarray data from different studies. Proc. Natl. Acad. Sci. U. S. A. 104, 18371–18376 (2007)

    Article  Google Scholar 

  7. Alter, O., Golub, G.: Reconstructing the pathways of a cellular system from genome-scale signals by using matrix and tensor computations. Proc. Natl. Acad. Sci. U. S. A. 102, 17559–17564 (2005)

    Article  Google Scholar 

  8. Barrett, T., Troup, D., Wilhite, S., Ledoux, P., Evangelista, C., Kim, I., Tomashevsky, M., Marshall, K., Phillippy, K., Sherman, P., Muertter, R., Holko, M., Ayanbule, O., Yefanov, A., Soboleva, A.: NCBI GEO: archive for functional genomics data sets–10 years on. Nucleic Acids Res. 10, D1005–D1010 (2005)

    Google Scholar 

  9. Tamara, G., Brett, W.: Tensor decompositions and applications. SIAM Review 51, 455–500 (2009)

    Article  MathSciNet  MATH  Google Scholar 

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© 2013 Springer International Publishing Switzerland

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Niida, A., Tremmel, G., Imoto, S., Miyano, S. (2013). Multilayer Cluster Heat Map Visualizing Biological Tensor Data. In: Setubal, J.C., Almeida, N.F. (eds) Advances in Bioinformatics and Computational Biology. BSB 2013. Lecture Notes in Computer Science(), vol 8213. Springer, Cham. https://doi.org/10.1007/978-3-319-02624-4_11

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  • DOI: https://doi.org/10.1007/978-3-319-02624-4_11

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-02623-7

  • Online ISBN: 978-3-319-02624-4

  • eBook Packages: Computer ScienceComputer Science (R0)

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