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Airflow and Particle Deposition in a Dry Powder Inhaler: An Integrated CFD Approach

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Book cover Simulation and Modeling Methodologies, Technologies and Applications

Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 256))

Abstract

An integrated computational model of a commercial Dry Powder Inhaler, DPI, device (i.e., Turbuhaler) is developed. The steady-state flow in a DPI is determined by solving the Navier-Stokes equations using FLUENT (v6.3) considering different flow models, e.g., laminar, k-ε, k-ω SST. Particle motion and deposition are described using an Eulerian-fluid/Lagrangian-particle approach. Particle/wall collisions are taken to result in deposition when the normal collision velocity is less than a size-dependent critical value. The flow rate and particle deposition are determined for a range of pressure drops (i.e., 800-8800Pa), as well as particle sizes corresponding to single particles and aggregates (i.e., 0.5-20μm). Overall, the simulation results are found to agree well with available experimental data for the volumetric outflow rate as well as the local and total particle deposition.

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Authors and Affiliations

  1. Department of Chemical Engineering, Aristotle University of Thessaloniki, P.O. Box 472, 54124, Thessaloniki, Greece

    Jovana Milenkovic & Costas Kiparissides

  2. CPERI/CERTH, 6th km Harilaou-Thermi rd., 57001, Thessaloniki, Greece

    Jovana Milenkovic, Alexandros H. Alexopoulos & Costas Kiparissides

  3. Department of Chemical Engineering, The Petroleum Institute, Abu Dhabi, U.A.E.

    Costas Kiparissides

Authors
  1. Jovana Milenkovic
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  2. Alexandros H. Alexopoulos
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  3. Costas Kiparissides
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Correspondence to Jovana Milenkovic .

Editor information

Editors and Affiliations

  1. Department of Computer Science, Monmouth University, West Long Branch, New Jersey, USA

    Mohammad S. Obaidat

  2. Polytechnic Institute of Setúbal / INSTICC, Setubal, Portugal

    Joaquim Filipe

  3. Systems Research Institute, Polish Academy of Sciences, Warsaw, Poland

    Janusz Kacprzyk

  4. Superior School of Technology of Setúbal / IPS, Setúbal, Portugal

    Nuno Pina

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Milenkovic, J., Alexopoulos, A.H., Kiparissides, C. (2014). Airflow and Particle Deposition in a Dry Powder Inhaler: An Integrated CFD Approach. In: Obaidat, M., Filipe, J., Kacprzyk, J., Pina, N. (eds) Simulation and Modeling Methodologies, Technologies and Applications. Advances in Intelligent Systems and Computing, vol 256. Springer, Cham. https://doi.org/10.1007/978-3-319-03581-9_9

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  • DOI: https://doi.org/10.1007/978-3-319-03581-9_9

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-03580-2

  • Online ISBN: 978-3-319-03581-9

  • eBook Packages: EngineeringEngineering (R0)

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