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Imaging and Evaluating Method as Part of Endoscopical Diagnostic Approaches

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Intelligent Information and Database Systems (ACIIDS 2014)

Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 8398))

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Abstract

Novel imaging diagnostic method - wireless capsule enteroscopy was used in experimental gastroenterology studies in pigs. We monitored the disintegration of two types of drug forms in gastrointestinal tract for next optimalisation of pharmaceutical technology process. In parallel, the plasma time profiles of the active component were detected. In second study, scanning of intestinal mucous lesions was done as diagnostic tool. The disintegration of tablets was perceptible in the duodenal-jejunal segment (until the 90th min) and culminated in the proximal jejunum (at the 3rd hour). The peak of maximal concentration was reached between the 3rd and 6th hour. The most common lesions induced by non-steroidal anti-inflammatory drugs were red spots and erosions. Sensitivity and specificity of capsule endoscopy were more than 80% and 95%, respectively. Wireless capsule endoscopy is a highly accurate non-invasive method for evaluation of experimental NSAID-induced enteropathy and evaluation of tablet disintegration proces in the intestine.

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Author information

Authors and Affiliations

  1. Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic

    Martin Kunes & Kamil Kuca

  2. 2nd Department of Internal Medicine – Gastroenterology, Charles University in Prague, Czech Republic

    Jaroslav Kvetina, Ilja Tacheci, Marcela Kopacova & Jan Bures

  3. Faculty of Medicine at Hradec Kralove, University Hospital, Hradec Kralove, Czech Republic

    Marcela Kopacova & Jan Bures

  4. Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic

    Milan Nobilis

  5. Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove, Czech Republic

    Ondrej Krejcar

Authors
  1. Martin Kunes
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  2. Jaroslav Kvetina
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  3. Ilja Tacheci
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  4. Marcela Kopacova
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  5. Jan Bures
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  6. Milan Nobilis
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  7. Ondrej Krejcar
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  8. Kamil Kuca
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Editor information

Editors and Affiliations

  1. Institute of Informatics, Wrocław University of Technology, Wybrzeże Wyspiańskiego 27, 50-370, Wrocław, Poland

    Ngoc Thanh Nguyen  & Bogdan Trawiński  & 

  2. Faculty of Engineering, Department of Computer Engineering, King Mongkut’s Institute of Technology Ladkrabang, 10520, Bangkok, Thailand

    Boonwat Attachoo

  3. Software Engineering Program, King Mongkut’s Institute of Technology Ladkrabang, 10520, Bangkok, Thailand

    Kulwadee Somboonviwat

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© 2014 Springer International Publishing Switzerland

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Kunes, M. et al. (2014). Imaging and Evaluating Method as Part of Endoscopical Diagnostic Approaches. In: Nguyen, N.T., Attachoo, B., Trawiński, B., Somboonviwat, K. (eds) Intelligent Information and Database Systems. ACIIDS 2014. Lecture Notes in Computer Science(), vol 8398. Springer, Cham. https://doi.org/10.1007/978-3-319-05458-2_62

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  • DOI: https://doi.org/10.1007/978-3-319-05458-2_62

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-05457-5

  • Online ISBN: 978-3-319-05458-2

  • eBook Packages: Computer ScienceComputer Science (R0)

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