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Multi-scale Simulation of T Helper Lymphocyte Differentiation

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Advances in Bioinformatics and Computational Biology (BSB 2014)

Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 8826))

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Abstract

The complex differentiation process of the CD4+ T helper lymphocytes shapes the form and the range of the immune response to different antigenic challenges. Few mathematical and computational models have addressed this key phenomenon. We here present a multiscale approach in which two different levels of description, i.e. a gene regulatory network model and an agent-based simulator for cell population dynamics, are integrated into a single immune system model. We illustrate how such model integration allows bridging a gap between gene level information and cell level population, and how the model is able to describe a coherent immunological behaviour when challenged with different stimuli.

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Author information

Authors and Affiliations

  1. CNR Consiglio Nazionale delle Ricerche, IAC Istituto per le Applicazioni del Calcolo, Roma, Italy

    P. Tieri, V. Prana, T. Colombo & F. Castiglione

  2. CNR Consiglio Nazionale delle Ricerche, IASI Istituto di Analisi dei Sistemi e Informatica, Roma, Italy

    D. Santoni

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  1. P. Tieri
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  2. V. Prana
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  3. T. Colombo
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  4. D. Santoni
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  5. F. Castiglione
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Editor information

Editors and Affiliations

  1. Departamento de Ciência de Computação, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, Pampulha, 31270-010, Belo Horizonte, MG, Brazil

    Sérgio Campos

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Tieri, P., Prana, V., Colombo, T., Santoni, D., Castiglione, F. (2014). Multi-scale Simulation of T Helper Lymphocyte Differentiation. In: Campos, S. (eds) Advances in Bioinformatics and Computational Biology. BSB 2014. Lecture Notes in Computer Science(), vol 8826. Springer, Cham. https://doi.org/10.1007/978-3-319-12418-6_16

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  • DOI: https://doi.org/10.1007/978-3-319-12418-6_16

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-12417-9

  • Online ISBN: 978-3-319-12418-6

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