Abstract
Mitochondria are mobile cellular organelles that form networks by fusion and fission. These events lead to an exchange of components responsible for maintaining membrane potential, i.e. mitochondrial health. Membrane potential can be disturbed by an imbalance of fission-triggering proteins. We expand an existing computational model of fusing and splitting mitochondria by representations of fission protein 1 (Fis1) and dynamin related protein 1 (Drp1) and perform parameter scans on simulations of it. Our relatively basic model already shows an effect of lower Fis1 and Drp1 recruitment rates, i.e. lower availability, on network structure and overall health. Various aspects of the real system can be incorporated into model, e.g. further regulatory proteins, a varying spatial distribution of Fis1 and Drp1, or consequences of changed mitochondrial network structure and health on their behaviour, e.g. under oxidative stress.
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Bittig, A.T., Haack, F., Maus, C., Uhrmacher, A.M.: Adapting rule-based model descriptions for simulating in continuous and hybrid space. In: Proc 9th CMSB, CMSB 2011, pp. 161–170. ACM Press, New York (2011)
Bittig, A.T., Matschegewski, C., Nebe, J.B., Stählke, S., Uhrmacher, A.M.: Membrane related dynamics and the formation of actin in cells growing on micro-topographies: a spatial computational model. BMC Systems Biology 8, 106 (2014)
Park, J., Lee, J., Choi, C.: Mitochondrial network determines intracellular ROS dynamics and sensitivity to oxidative stress through switching Inter-Mitochondrial messengers. PLoS One 6(8), e23211 (2011)
Patel, P.K., Shirihai, O., Huang, K.C.: Optimal dynamics for quality control in spatially distributed mitochondrial networks. PLoS Comput. Biol. 9(7), e1003108 (2013)
Reinhardt, F., Schultz, J., Waterstradt, R., Baltrusch, S.: The mitochondrial fission proteins Fis1 and Drp1 are important for glucose-induced insulin secretion in glucose-responsive INS1 832/13 cells. Exp. Clin. Endocrinol Diabetes 121(10), P17 (2013)
Schmitt, H., Lenzen, S., Baltrusch, S.: Glucokinase mediates coupling of glycolysis to mitochondrial metabolism but not to beta cell damage at high glucose exposure levels. Diabetologia 54(7), 1744–1755 (2011)
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Bittig, A.T., Reinhardt, F., Baltrusch, S., Uhrmacher, A.M. (2014). Predictive Modelling of Mitochondrial Spatial Structure and Health. In: Mendes, P., Dada, J.O., Smallbone, K. (eds) Computational Methods in Systems Biology. CMSB 2014. Lecture Notes in Computer Science(), vol 8859. Springer, Cham. https://doi.org/10.1007/978-3-319-12982-2_20
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DOI: https://doi.org/10.1007/978-3-319-12982-2_20
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-12981-5
Online ISBN: 978-3-319-12982-2
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