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Cancer Based Pharmacogenomics Network for Drug Repurposing

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Trends and Applications in Knowledge Discovery and Data Mining (PAKDD 2014)

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Abstract

Pharmacogenomics (PGx) as an emerging field, is poised to change the way we practice medicine and deliver health care by customizing drug therapies on the basis of each patient’s genetic makeup. A large volume of PGx data including information on relationships among drugs, genes, and single nucleotide polymorphisms (SNPs) has been accumulated. Normalized and integrated PGx information could facilitate revelation of hidden relationships among drug treatments, genomic variations, and phenotype traits to better support drug discovery and next generation of treatment. In this study, we constructed a normalized cancer based PGx network (CPN) by integrating cancer orientated PGx information from multiple well known PGx resources including the Pharmacogenomics Knowledge Base (PharmGKB), the FDA Pharmacogenomic Biomarkers in Drug Labeling, and the Catalog of Published Genome-Wide Association Studies. The ultimate goal of the CPN is to provide comprehensive cancer specific PGx information to support oncology related research, including cancer based drug discovery – drug repurposing. We have successfully demonstrated the capability of the CPN for drug repurposing by conducting two case studies.

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Acknowledgement

This work was supported by the Pharmacogenomic Research Network (NIH/NIGMS-U19 GM61388).

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Authors and Affiliations

  1. Department of Medical Informatics, School of Public Health, Jilin University, Changchun, 130021, China

    Liwei Wang

  2. Department of Health Science Research, Mayo Clinic, Rochester, MN, 55901, USA

    Hongfang Liu & Christopher G. Chute

  3. Department of Information Systems, University of Maryland Baltimore County, Baltimore, MD, 21250, USA

    Qian Zhu

Authors
  1. Liwei Wang
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  2. Hongfang Liu
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  3. Christopher G. Chute
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  4. Qian Zhu
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Corresponding author

Correspondence to Qian Zhu .

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Editors and Affiliations

  1. National Chiao Tung University, Hsinchu, Taiwan

    Wen-Chih Peng

  2. Google Research, Mountain View, California, USA

    Haixun Wang

  3. University of Melbourne, Melbourne, Victoria, Australia

    James Bailey

  4. National Cheng Kung University, Tainan, Taiwan

    Vincent S. Tseng

  5. Japan Advanced Institute of Science and Technology, Nomi City, Japan

    Tu Bao Ho

  6. Nanjing University, Nanjing, China

    Zhi-Hua Zhou

  7. National Chengchi University, Taipei, Taiwan

    Arbee L.P. Chen

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Wang, L., Liu, H., Chute, C.G., Zhu, Q. (2014). Cancer Based Pharmacogenomics Network for Drug Repurposing. In: Peng, WC., et al. Trends and Applications in Knowledge Discovery and Data Mining. PAKDD 2014. Lecture Notes in Computer Science(), vol 8643. Springer, Cham. https://doi.org/10.1007/978-3-319-13186-3_57

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  • DOI: https://doi.org/10.1007/978-3-319-13186-3_57

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-13185-6

  • Online ISBN: 978-3-319-13186-3

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