Skip to main content
SpringerLink
Log in

Volumetric Topological Analysis on In Vivo Trabecular Bone Magnetic Resonance Imaging

  • Conference paper
Advances in Visual Computing (ISVC 2014)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 8887))

Included in the following conference series:

Abstract

Osteoporosis is a common bone disease associated with increased risk of low-trauma fractures leading to substantial morbidity, mortality, and financial costs. Clinically, osteoporosis is defined by low bone mineral density (BMD); however, increasing evidence suggests that trabecular bone (TB) micro-architectural quality is an important determinant of bone strength and fracture risk. Recently developed volumetric topological analysis (VTA) is a unique method that characterizes individual trabeculae on the continuum between a perfect plate and a perfect rod. In this paper, an improved VTA algorithm is presented that eliminates the binarization step using fuzzy skeletonization. Its repeat scan reproducibility is evaluated for two different in vivo magnetic resonance imaging (MRI) protocols. High intra-class correlation coefficients, greater than 0.93, were observed for both the knee and the wrist MRI. The ability of the method to detect testosterone treatment effects of a two-year longitudinal study on hypogonadal men is also presented. Our method shows statistically significant improvement of TB quality as early as 6 months and the trend was observed to continue at 12 and 24 months.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Benito, M., Vasilic, B., Wehrli, F.W., Bunker, B., Wald, M., Gomberg, B., Wright, A.C., Zemel, B., Cucchiara, A., Snyder, P.J.: Effect of testosterone replacement on trabecular architecture in hypogonadal men. J. Bone and Mine. Res. 20(10), 1785–1791 (2005)

    Article  Google Scholar 

  2. Chang, G., Wang, L., Liang, G., Babb, J.S., Saha, P.K., Regatte, R.R.: Reproducibility of subregional trabecular bone micro-architectural measures derived from 7-tesla magnetic resonance images. MAGMA 24(3), 121–125 (2011)

    Article  Google Scholar 

  3. Feldkamp, L.A., Goldstein, S.A., Parfitt, A.M., Jesion, G., Kleerekoper, M.: The direct examination of three-dimensional bone architecture in vitro by computed tomography. J. Bone Min. Res. 4, 3–11 (1989)

    Article  Google Scholar 

  4. Hildebrand, T., Laib, A., Muller, R., Dequeker, J., Rüegsegger, P.: Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus. J. Bone Min. Res. 14, 1167–1174 (1999)

    Article  Google Scholar 

  5. Jin, D., Saha, P.K.: A new fuzzy skeletonization algorithm and its applications to medical imaging, September 11-13 (2013)

    Google Scholar 

  6. Kleerekoper, M., Villanueva, A.R., Stanciu, J., Rao, D.S., Parfitt, A.M.: The role of three-dimensional trabecular microstructure in the pathogenesis of vertebral compression fractures. Cal. Tis. Int. 37, 594–597 (1985)

    Article  Google Scholar 

  7. Laib, A., Hauselmann, H.J., Rüegsegger, P.: In vivo high resolution 3d-qct of the human forearm. Tech. Heal. Care 6, 329–337 (1998)

    Google Scholar 

  8. Lam, S.C., Wald, M.J., Rajapakse, C.S., Liu, Y., Saha, P.K., Wehrli, F.W.: Performance of the mri-based virtual bone biopsy in the distal radius: serial reproducibility and reliability of structural and mechanical parameters in women representative of osteoporosis study populations. Bone 49(4), 895–903 (2011)

    Article  Google Scholar 

  9. Liu, Y., Jin, D., Li, C., Janz, K.F., Burns, T.L., Torner, J.C., Levy, S.M., Saha, P.K.: A robust algorithm for thickness computation at low resolution and its application to in vivo trabecular bone ct imaging. IEEE Trans. Bio. Eng. (2014)

    Google Scholar 

  10. Majumdar, S.: Magnetic resonance imaging of trabecular bone structure. Top. Magn. Reson. Imaging 13(5), 323–334 (2002)

    Article  Google Scholar 

  11. Parfitt, A.M., Mathews, C.H.E., Villanueva, A.R., Kleerekoper, M., Frame, B., Rao, D.S.: Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. implications for the microanatomic and cellular mechanisms of bone loss. J Clin Inv. 72, 1396–1409 (1983)

    Article  Google Scholar 

  12. Recker, R.R.: Architecture and vertebral fracture. Cal. Tis. Int. 53(Suppl. 1), S139–S142 (1993)

    Google Scholar 

  13. Saha, P.K., Chaudhuri, B.B.: Detection of 3-d simple points for topology preserving transformations with application to thinning. IEEE Trans. Pat. Anal. Mach. Intel. 16, 1028–1032 (1994)

    Article  Google Scholar 

  14. Saha, P.K., Chaudhuri, B.B.: 3d digital topology under binary transformation with applications. Comp. Vis. Imag. Und. 63, 418–429 (1996)

    Article  Google Scholar 

  15. Saha, P.K., Gomberg, B.R., Wehrli, F.W.: Three-dimensional digital topological characterization of cancellous bone architecture. Int. J. Imag. Sys. Tech. 11, 81–90 (2000)

    Article  Google Scholar 

  16. Saha, P.K., Wehrli, F.W., Gomberg, B.R.: Fuzzy distance transform: theory, algorithms, and applications. Comp. Vis. Imag. Und. 86, 171–190 (2002)

    Article  MATH  Google Scholar 

  17. Saha, P.K., Xu, Y., Duan, H., Heiner, A., Liang, G.: Volumetric topological analysis: a novel approach for trabecular bone classification on the continuum between plates and rods. IEEE Trans. Med. Imaging 29(11), 1821–1838 (2010)

    Article  Google Scholar 

  18. Vesterby, A., Gundersen, H.J., Melsen, F., Mosekilde, L.: Marrow space star volume in the iliac crest decreases in osteoporotic patients after continuous treatment with fluoride, calcium, and vitamin d2 for five years. Bone 12(1), 33–37 (1991)

    Article  Google Scholar 

  19. Wehrli, F.W., Gomberg, B.R., Saha, P.K., Song, H.K., Hwang, S.N., Snyder, P.J.: Digital topological analysis of in vivo magnetic resonance microimages of trabecular bone reveals structural implications of osteoporosis. J. Bone Miner. Res. 16, 1520–1531 (2001)

    Article  Google Scholar 

  20. Wehrli, F.W., Saha, P.K., Gomberg, B.R., Song, H.K., Snyder, P.J., Benito, M., Wright, A., Weening, R.: Role of magnetic resonance for assessing structure and function of trabecular bone. Top. Mag. Res. Imag. 13, 335–356 (2002)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of ECE and Radiology, University of Iowa, Iowa City, IA, USA

    Cheng Chen, Dakai Jin, Yinxiao Liu & Punam K. Saha

  2. Department of Radiology, NYU Langone Medical Center, New York, NY, USA

    Gregory Chang & Ravinder R. Regatte

  3. Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA

    Felix W. Wehrli & Peter J. Snyder

Authors
  1. Cheng Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dakai Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yinxiao Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Felix W. Wehrli
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Gregory Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Peter J. Snyder
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Ravinder R. Regatte
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Punam K. Saha
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Computer Science and Engineering, University of Nevada at Reno, USA

    George Bebis

  2. NASA Ames Research Center, Moffett Field, CA, USA

    Richard Boyle

  3. Lawrence Berkeley National Laboratory, Berkeley, CA, USA

    Bahram Parvin

  4. Desert Research Institute, Reno, NV, USA

    Darko Koracin

  5. The University of Texas at Dallas, 75080, Richardson, TX, USA

    Ryan McMahan

  6. NextGen Interactions, 27604, Raleigh, NC, USA

    Jason Jerald

  7. Indiana University, 46202, Indianapolis, IN, USA

    Hui Zhang

  8. Microsoft Research, 1 Microsoft Way, 98052, Redmond, WA, USA

    Steven M. Drucker

  9. University of Delaware, 19716-2712, Newark, DE, USA

    Chandra Kambhamettu

  10. Intel Corp., 95054, Santa Clara, CA, USA

    Maha El Choubassi

  11. Computer Graphics and Interactive Media Lab, Department of Computer Science, University of Houston, 77004, Houston, TX, USA

    Zhigang Deng

  12. NVIDIA, 34788, Leesburg, FL, USA

    Mark Carlson

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer International Publishing Switzerland

About this paper

Cite this paper

Chen, C. et al. (2014). Volumetric Topological Analysis on In Vivo Trabecular Bone Magnetic Resonance Imaging. In: Bebis, G., et al. Advances in Visual Computing. ISVC 2014. Lecture Notes in Computer Science, vol 8887. Springer, Cham. https://doi.org/10.1007/978-3-319-14249-4_47

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-14249-4_47

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-14248-7

  • Online ISBN: 978-3-319-14249-4

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics

Search

Navigation