Skip to main content

Towards the Reconstruction of Moving Images by Populations of Retinal Ganglion Cells

  • Conference paper
Artificial Computation in Biology and Medicine (IWINAC 2015)

Abstract

One of the many important functions the brain carries out is interpreting the external world. For this, one sense that most mammals rely on is vision. The first stage of the visual system is the image processing whose capture takes place in the retina. Here, photoreceptors cells transform light into electrical impulses that are then guided by amacrine, bipolar, horizontal and some glial cells up to the ganglion cells layer. Ganglion cells decode the visual information to be interpreted by the visual cortex. The understanding of the mechanism for decoding the visual information is a major task and challenge in neuroscience. This is especially true for images that change with time, for example during movement. For this purpose, extracellular recordings with a 100 multi-electrode-array (MEA) were carried out in the retinal ganglion cells layer of mice. Different moving patterns and actual images were used to stimulate the retina. Here, we present a new strategy for analysis over the spike trains recorded allowing the reconstruction of the actual stimuli with a reduced number of ganglion cell responses.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Masland, R.H.: The Neuronal Organization of the Retina. Neuron 76(2), 266–280 (2012), http://www.cell.com/article/S0896627312008835/abstract , doi:10.1016/j.neuron.2012.10.002

    Article  Google Scholar 

  2. Hoon, M., Okawa, H., Santina, L.D., Wong, R.O.: Functional architecture of the retina: Development and disease. Progress in Retinal and Eye Research 42, 44–84 (2014), http://www.sciencedirect.com/science/article/pii/S135094621400038X , doi: http://dx.doi.org/10.1016/j.preteyeres.2014.06.003

  3. Gollisch, T., Meister, M.: Eye smarter than scientists believed: Neural computations in circuits of the retina. Neuron 65(2), 150–164 (2010), http://www.sciencedirect.com/science/article/pii/S0896627309009994 , doi: http://dx.doi.org/10.1016/j.neuron.2009.12.00

  4. Nirenberg, S., Pandarinath, C.: Retinal prosthetic strategy with the capacity to restore normal vision. Proceedings of the National Academy of Sciences 109(37), 15012–15017 (2012), arXiv: http://www.pnas.org/content/109/37/15012.full.pdf+html , doi:10.1073/pnas.1207035109

  5. Fernández, E., Ferrández, J.-M., Ammermüller, J., Normann, R.A.: Population coding in spike trains of simultaneously recorded retinal ganglion cells1. Brain Research 887(1), 222–2229 (2000), http://www.sciencedirect.com/science/article/pii/S0006899300030729 , doi: http://dx.doi.org/10.1016/S0006-89930003072-9

  6. Bongard, M., Micol, D., Fernández, E.: NEV2lkit: A new open source tool for handling neural event files from multi-electrode recordings. International Journal of Neural Systems 24(04), 1450009, pMID: 24694167 (2014), arXiv: http://www.worldscientific.com/doi/pdf/10.1142/S0129065714500099 , doi:10.1142/S0129065714500099

  7. Straw, A.D.: Vision egg: An open-source library for realtime visual stimulus generation. Frontiers in Neuroinformatics 2, http://dx.doi.org/10.3389/neuro.11.004.2008 , doi:10.3389/neuro.11.004.2008

  8. Van Wyk, M., Wässle, H., Taylor, W.R.: Receptive field properties of on- and off-ganglion cells in the mouse retina. Visual Neuroscience 26, 297–308 (2009), http://journals.cambridge.org/article_S0952523809990137 , doi:10.1017/S0952523809990137

    Article  Google Scholar 

  9. Zhang, Y., Kim, I.-J., Sanes, J.R., Meister, M.: The most numerous ganglion cell type of the mouse retina is a selective feature detector. Proceedings of the National Academy of Sciences 109(36), E2391–E2398 (2012), arXiv: http://www.pnas.org/content/109/36/E2391.full.pdf+html , http://www.pnas.org/content/109/36/E2391.abstract , doi:10.1073/pnas.1211547109

  10. Goudail, F., Réfrégier, P., Delyon, G.: Bhattacharyya distance as a contrast parameter for statistical processing of noisy optical images. J. Opt. Soc. Am. A 21(7), 1231–1240 (2004), http://josaa.osa.org/abstract.cfm?URI=josaa-21-7-1231 , doi:10.1364/JOSAA.21.001231

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ariadna Díaz-Tahoces .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this paper

Cite this paper

Díaz-Tahoces, A., Martínez-Álvarez, A., García-Moll, A., Humphreys, L., Bolea, J.Á., Fernández, E. (2015). Towards the Reconstruction of Moving Images by Populations of Retinal Ganglion Cells. In: Ferrández Vicente, J., Álvarez-Sánchez, J., de la Paz López, F., Toledo-Moreo, F., Adeli, H. (eds) Artificial Computation in Biology and Medicine. IWINAC 2015. Lecture Notes in Computer Science(), vol 9107. Springer, Cham. https://doi.org/10.1007/978-3-319-18914-7_23

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-18914-7_23

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-18913-0

  • Online ISBN: 978-3-319-18914-7

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics