Abstract
Simulations of the biomechanical behavior of the Mitral Valve (MV) based on simplified geometric models are difficult to interpret due to significant intra-patient variations and pathologies in the MV geometry. Thus, it is critical to use a systematic approach to characterization and population-averaging of the patient-specific models. We introduce a multi-scale modeling framework for characterizing the entire MV apparatus geometry via a relatively small set of parameters. The leaflets and annulus are analyzed using a superquadric surface model superimposed with fine-scale filtered level-set field. Filtering of fine-scale features is performed in a spectral space to allow control of resolution, resampling and robust averaging. Chordae tendineae structure is modeled using a medial axis representation with superimposed filtered pointwise cross-sectional area field. The chordae topology is characterized using orientation and spatial distribution functions. The methodology is illustrated with the analysis of an ovine MV microtomography imaging data.
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Research reported in this publication was supported by National Heart, Lung, and Blood Institute of the National Institutes of Health under award number R01HL119297. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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Khalighi, A.H. et al. (2015). A Comprehensive Framework for the Characterization of the Complete Mitral Valve Geometry for the Development of a Population-Averaged Model. In: van Assen, H., Bovendeerd, P., Delhaas, T. (eds) Functional Imaging and Modeling of the Heart. FIMH 2015. Lecture Notes in Computer Science(), vol 9126. Springer, Cham. https://doi.org/10.1007/978-3-319-20309-6_19
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DOI: https://doi.org/10.1007/978-3-319-20309-6_19
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