Abstract
It has been documented that Methylglyoxal (MG) concentrations in cells from diabetic patients are higher than cells from non-diabetics. Despite ongoing research efforts, a clear understanding of the mechanisms involving MG as well as methods to reduce MG concentrations in diabetic patients have yet to be obtained. Consistent growth in the patient demographic affected by adult disease has led to increased interest in the causes of the disease. Implications of MG with widespread adult diseases such as diabetes, obesity, etc. have necessitated the investigation of the role MG in these diseases, methods to regulate MG concentration levels, possible and cures that involve MG. In this paper, we propose a cure through manipulating MG generation rates by either using the SPE1 gene or handling the Polyamine externally.
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References
Asanuma, N., Yoshii, T., Kikuchi, M., Hino, T.: Effects of the overexpression of Fructose-1, 6-bhisphosphate aldolase on fermentation pattern and transcription of the genes encoding lactate dehydrogenase and pyruvate formate-lyase in a ruminal bacterium, Streptococcus bovis. J. Gen. Appl. Microbiol. 50, 71–78 (2004)
Berman, J., Sudbery, P.E.: Candida albicans: a molecular revolution built on lessons from budding yeast. Nat. Rev. 3, 918–930 (2002)
Carlisle, P.L., Kadosh, D.: A genome-wide transcriptional analysis of morphology determination in Candida albicans. Mol. Biol. Cell 24, 246–260 (2013)
Chan, W.H., Wu, H.J., Shiao, N.H.: Apoptotic signaling in methylglyoxal‐treated human osteoblasts involves oxidative stress, c‐Jun N‐terminal kinase, caspase‐3, and p21‐activated kinase 2. J. Cell. Biochem. 100, 1056–1069 (2007)
Hanahan, D.: Studies on transformation of Escherichia coli with plasmids. J. Mol. Biol. 166, 557–580 (1983)
Kalapos, M.P.: Methylglyoxal in living organisms: chemistry, biochemistry, toxicology and biological implications. Toxicol. Lett. 110, 145–175 (1999)
Kwak, M.K., Ku, M., Kang, S.O.: NAD+-linked alcohol dehydrogenase regulates methylglyoxal concentration in Candida albicans. FEBS Lett. 588, 1144–1153 (2014)
Matafome, P., Sena, C., Seica, R.: Methylglyoxal, obesity, and diabetes. Endocrine 43, 472–484 (2013)
Ramasamy, R., Yan, S.F., Schmidt, A.M.: Methylglyoxal comes of AGE. Cell 124, 258–260 (2006)
Rodaki, A., Young, T., Brown, A.J.: Effects of depleting the essential central metabolic enzyme fructose-1,6-bisphosphate aldolase on the growth and viability of Candida albicans: implications for antifungal drug target discovery. Eukaryotic cell. 5, 1371–1377 (2006)
Sambrook, J., Fritsch, E.F., Maniatis, T.: Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor, New York (1989)
Acknowledgement
We thank W.A. Fonzi, M. Whiteway and G.R. Fink for providing the C. albicans Strains and plasmids.
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Lee, JH., Cho, HY., Ahn, YJ., Yoon, T. (2015). Interplay Between Methylglyoxal and Polyamine in Candida Albicans . In: Huang, DS., Jo, KH., Hussain, A. (eds) Intelligent Computing Theories and Methodologies. ICIC 2015. Lecture Notes in Computer Science(), vol 9226. Springer, Cham. https://doi.org/10.1007/978-3-319-22186-1_41
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DOI: https://doi.org/10.1007/978-3-319-22186-1_41
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