Abstract
The main difficulty when modelling gene networks is the identification of the parameters that govern the dynamics. Here we present a new approach based on Hoare logic and weakest preconditions (a la Dijkstra) that generates constraints on the parameter values: Once proper specifications are extracted from biological traces, they play a role similar to programs in the classical Hoare logic. We firstly remind the discrete modelling for genetic networks defined by René Thomas. Then, we define the Hoare/Dijkstra method extended to gene networks, that extracts the weakest precondition on parameter values.
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References
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Bernot, G., Comet, JP., Roux, O. (2015). A Genetically Modified Hoare Logic that Identifies the Parameters of a Gene Network. In: Roux, O., Bourdon, J. (eds) Computational Methods in Systems Biology. CMSB 2015. Lecture Notes in Computer Science(), vol 9308. Springer, Cham. https://doi.org/10.1007/978-3-319-23401-4_2
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DOI: https://doi.org/10.1007/978-3-319-23401-4_2
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