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Mutual Entrainment of Cardiac-Oscillators Through Mechanical Interaction

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Book cover Biomimetic and Biohybrid Systems (Living Machines 2016)

Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 9793))

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Abstract

This paper focus on bio-robots driven by cardiomyocyte-powered actuators. Towards biomaterial-based robotic actuators that exhibit co-operative motion, this study intends to deal with mutual entrainment between two cardiac-oscillators with mechanical interaction. The cardiac-oscillator is an oriented collagen sheet seeded cultured rat cardiomyocytes. Mechanically coupled cardiac-oscillator sysytem was developed consisting of two cardiac-oscillators connected mechanically via a PDMS film. Mechanically coupled cardiac-oscillator system and a single cardiac-oscillator was applied electric stimulation for investigating the function of mechanical structure. As a result of experiment, we observed mutual entrainment occurred in only mechanically coupled structure.

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References

  1. Webster, V.A., Hawley, E.L., Akkus, O., Chiel, H.J., Quinn, R.D.: Fabrication of electrocompacted aligned collagen morphs for cardiomyocyte powered living machines. In: Wilson, S.P., Verschure, P.F.M.J., Mura, A., Prescott, T.J. (eds.) Living Machines 2015. LNCS, vol. 9222, pp. 429–440. Springer, Heidelberg (2015)

    Chapter  Google Scholar 

  2. Nawroth, J.C., Lee, H., Feinberg, A.W., Ripplinger, C.M., McCain, M.L., Grosberg, A., Dabiri, J.O., Perker, K.K.: A tissue-engineered jellyfish with biomimetic propulsion. Nat. Biotechnol. 30, 792–797 (2012)

    Article  Google Scholar 

  3. Akiyama, Y., Odaira, K., Sakiyama, K., Hoshino, T., Iwabuchi, K., Morishima, K.: Rapidly-moving insect muscle-powered microrobot and its chemical acceleration. Biomed. Microdevices 14(6), 979–986 (2012)

    Article  Google Scholar 

  4. Bers, D.M.: Cardiac excitation-contraction coupling. Nature 415(6868), 198–205 (2002)

    Article  Google Scholar 

  5. Iribe, G., Jin, H., Naruse, K.: Role of sarcolemmal BKCa channels in stretch-induced extrasystoles in isolated chick hearts. Circ. J. 75(11), 2552–2558 (2011)

    Article  Google Scholar 

  6. Isobe, Y., Kosaka, T., Kuwahara, G., Mikami, H., Saku, T., Kodama, S.: Oriented collagen scaffolds for tissue engineering. Materials 5(3), 501–511 (2012)

    Article  Google Scholar 

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Authors and Affiliations

  1. Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-machi, Toyonaka, Osaka, 560-8531, Japan

    Koki Maekawa, Naoki Inoue, Masahiro Shimizu & Koh Hosoda

  2. Atree, Inc., 1-181 Sugi Machi, Yamatokoriyama City, Nara, 639-1121, Japan

    Yoshihiro Isobe & Taro Saku

Authors
  1. Koki Maekawa
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  2. Naoki Inoue
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  3. Masahiro Shimizu
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  4. Yoshihiro Isobe
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  5. Taro Saku
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  6. Koh Hosoda
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Corresponding author

Correspondence to Koki Maekawa .

Editor information

Editors and Affiliations

  1. University of Bristol , Bristol, United Kingdom

    Nathan F. Lepora

  2. Universitat Pompeu Fabra , Barcelona, Spain

    Anna Mura

  3. University of Lincoln , London, United Kingdom

    Michael Mangan

  4. Universitat Pompeu Fabra , Barcelona, Spain

    Paul F.M.J. Verschure

  5. Heriot-Watt University , Edinburgh, United Kingdom

    Marc Desmulliez

  6. University of Sheffield , Sheffield, United Kingdom

    Tony J. Prescott

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© 2016 Springer International Publishing Switzerland

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Maekawa, K., Inoue, N., Shimizu, M., Isobe, Y., Saku, T., Hosoda, K. (2016). Mutual Entrainment of Cardiac-Oscillators Through Mechanical Interaction. In: Lepora, N., Mura, A., Mangan, M., Verschure, P., Desmulliez, M., Prescott, T. (eds) Biomimetic and Biohybrid Systems. Living Machines 2016. Lecture Notes in Computer Science(), vol 9793. Springer, Cham. https://doi.org/10.1007/978-3-319-42417-0_48

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  • DOI: https://doi.org/10.1007/978-3-319-42417-0_48

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42416-3

  • Online ISBN: 978-3-319-42417-0

  • eBook Packages: Computer ScienceComputer Science (R0)

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