Abstract
Neural oscillations are considered to reflect the activity of neural populations, and are thus closely associated with brain function. However, the extent to which different anesthetic agents exert unique effects on such oscillations is unclear. A mixture of three anesthetics (medetomidine, midazolam, and butorphanol) was recently developed as an alternative to ketamine, which has potential addictive effects. Yet, little is known about the effects of this combination of anesthetics on neural oscillations. In this study, we used multi-channel electrophysiological recording and flavoprotein endogenous imaging to compare sound-driven oscillations in primary auditory cortical neurons after administration of ketamine vs. a medetomidine, midazolam, and butorphanol mixture. We observed differences in high gamma activities (over 120 Hz) between these two anesthetics, independent of cortical layers, but found no differences in activities including lower frequency components (<120 Hz). Our results provide new information about how specific anesthetics influence sound-driven neural oscillations.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Belitski, A., Gretton, A., Magri, C., Murayama, Y., Montemurro, M.A., Logothetis, N.K., Panzeri, S.: Low-frequency local field potentials and spikes in primary visual cortex convey independent visual information. J. Neurosci. 28, 5696–5709 (2008)
van der Loo, E., Gais, S., Congedo, M., Vanneste, S., Plazier, M., Menovsky, T., Van de Heyning, P., De Ridder, D.: Tinnitus intensity dependent gamma oscillations of the contralateral auditory cortex. PLoS ONE 4, e7396 (2009)
Lazarewicz, M.T., Ehrlichman, R.S., Maxwell, C.R., Gandal, M.J., Finkel, L.H., Siegel, S.J.: Ketamine modulates theta and gamma oscillations. J. Cogn. Neurosci. 22, 1452–1464 (2010)
Li, A., Zhang, L., Liu, M., Gong, L., Liu, Q., Xu, F.: Effects of different anesthetics on oscillations in the rat olfactory bulb. J. Am. Assoc. Lab. Anim. Sci. 51, 458–463 (2012)
Newport, D.J., Carpenter, L.L., McDonald, W.M., Potash, J.B., Tohen, M., Nemeroff, C.B.: Ketamine and Other NMDA Antagonists: early clinical trials and possible mechanisms in depression. Am. J. Psychiatry 172, 950–966 (2015)
Kirihara, Y., Takechi, M., Kurosaki, K., Kobayashi, Y., Saito, Y., Takeuchi, T.: Effects of an anesthetic mixture of medetomidine, midazolam, and butorphanol in rats-strain difference and antagonism by atipamezole. Exp. Anim. 65, 27–36 (2016)
Noto, M., Nishikawa, J., Tateno, T.: An analysis of nonlinear dynamics underlying neural activity related to auditory induction in the rat auditory cortex. Neuroscience 318, 58–83 (2016)
Shibuki, K., Hishida, R., Murakami, H., Kudoh, M., Kawaguchi, T., Watanabe, M., Watanabe, S., Kouuchi, T., Tanaka, R.: Dynamic imaging of somatosensory cortical activity in the rat visualized by flavoprotein autofluorescence. J. Physiol. 549, 919–927 (2003)
Kaur, S., Rose, H.J., Lazar, R., Liang, K., Metherate, R.: Spectral integration in primary auditory cortex: laminar processing of afferent input, in vivo and in vitro. Neuroscience 134, 1033–1045 (2005)
DeFelipe, J., Alonso-Nanclares, L., Arellano, J.I.: Microstructure of the neocortex: comparative aspects. J. Neurocytol. 31, 299–316 (2002)
Chandran Ks, S., Mishra, A., Shirhatti, V., Ray, S.: Comparison of matching pursuit algorithm with other signal processing techniques for computation of the time-frequency power spectrum of brain signals. J. Neurosci. 36, 3399–3408 (2016)
Sakata, S., Harris, K.D.: Laminar structure of spontaneous and sensory-evoked population activity in auditory cortex. Neuron 64, 404–418 (2009)
Stolzberg, D., Chrostowski, M., Salvi, R.J., Allman, B.L.: Intracortical circuits amplify sound-evoked activity in primary auditory cortex following systemic injection of salicylate in the rat. J. Neurophysiol. 108, 200–214 (2012)
Hunt, M.J., Olszewski, M., Piasecka, J., Whittington, M.A., Kasicki, S.: Effects of NMDA receptor antagonists and antipsychotics on high frequency oscillations recorded in the nucleus accumbens of freely moving mice. Psychopharmacol. (Berl) 232, 4525–4535 (2015)
Plourde, G., Reed, S.J., Chapman, C.A.: Attenuation of High-Frequency (50–200 Hz) Thalamocortical Electroencephalographic Rhythms by Isoflurane in Rats Is More Pronounced for the Thalamus than for the Cortex. Anesth. Analg. (2016)
Saari, T.I., Uusi-Oukari, M., Ahonen, J., Olkkola, K.T.: Enhancement of GABAergic activity: neuropharmacological effects of benzodiazepines and therapeutic use in anesthesiology. Pharmacol. Rev. 63, 243–267 (2011)
Acknowledgements
In this work, T.T. was supported by the Suzuken Memorial Foundation (Japan) and a Grant-in-Aid for Scientific Research (B) (No. 15H02772) and Exploratory Research (No. 15K12091) (Japan). H.O. is supported by the Tateisi Science and Technology Foundation (Japan).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing AG
About this paper
Cite this paper
Osanai, H., Tateno, T. (2016). Differential Effect of Two Types of Anesthesia on Sound-Driven Oscillations in the Rat Primary Auditory Cortex. In: Hirose, A., Ozawa, S., Doya, K., Ikeda, K., Lee, M., Liu, D. (eds) Neural Information Processing. ICONIP 2016. Lecture Notes in Computer Science(), vol 9948. Springer, Cham. https://doi.org/10.1007/978-3-319-46672-9_41
Download citation
DOI: https://doi.org/10.1007/978-3-319-46672-9_41
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-46671-2
Online ISBN: 978-3-319-46672-9
eBook Packages: Computer ScienceComputer Science (R0)