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Classification of Splice-Junction DNA Sequences Using Multi-objective Genetic-Fuzzy Optimization Techniques

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Artificial Intelligence and Soft Computing (ICAISC 2017)

Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 10245))

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Abstract

The main goal of this paper is the application of our fuzzy rule-based classification technique with genetically optimized accuracy-interpretability trade-off to the classification of the splice-junction DNA sequences coming from the Molecular Biology (Splice-junction Gene Sequences) benchmark data set (available from the UCI repository). Two multi-objective evolutionary optimization algorithms are employed and compared in the framework of our technique, i.e., the well-known Strength Pareto Evolutionary Algorithm 2 (SPEA2) and our SPEA2’s generalization (referred to as SPEA3) characterized by a higher spread and a better-balanced distribution of solutions. A comparative analysis with 15 alternative approaches is also performed.

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References

  1. Maji, P., Paul, S.: Scalable Pattern Recognition Algorithms: Applications in Computational Biology and Bioinformatics. Springer, Cham (2014)

    Book  MATH  Google Scholar 

  2. Towell, G., Shavlik, J.W.: Interpretation of artificial neural networks: mapping knowledge-based neural networks into rules. In: Proceedings of the 4th International Conference on Neural Information Processing Systems (NIPS 1991), pp. 977–984. Morgan Kaufmann Publishers Inc., Denver (1991)

    Google Scholar 

  3. Rudziński, F.: A multi-objective genetic optimization of interpretability-oriented fuzzy rule-based classifiers. Appl. Soft Comput. 38, 118–133 (2016)

    Article  Google Scholar 

  4. Gorzałczany, M.B., Rudziński, F.: A multi-objective genetic optimization for fast, fuzzy rule-based credit classification with balanced accuracy and interpretability. Appl. Soft Comput. 40, 206–220 (2016)

    Article  Google Scholar 

  5. Gorzałczany, M.B., Rudziński, F.: Interpretable and accurate medical data classification - a multi-objective genetic-fuzzy optimization approach. Expert Syst. Appl. 71, 26–39 (2017)

    Article  Google Scholar 

  6. Gorzałczany, M.B., Rudziński, F.: Handling fuzzy systems’ accuracy-interpretability trade-off by means of multi-objective evolutionary optimization methods - selected problems. Bull. Pol. Acad. Sci. Tech. Sci. 63(3), 791–798 (2015)

    Google Scholar 

  7. Fazzolari, M., Alcala, R., Nojima, Y., Ishibuchi, H., Herrera, F.: A review of the application of multiobjective evolutionary fuzzy systems: current status and further directions. IEEE Trans. Fuzzy Syst. 21(1), 45–65 (2013)

    Article  Google Scholar 

  8. Gorzałczany, M.B., Rudziński, F.: Accuracy vs. interpretability of fuzzy rule-based classifiers: an evolutionary approach. In: Rutkowski, L., Korytkowski, M., Scherer, R., Tadeusiewicz, R., Zadeh, L.A., Zurada, J.M. (eds.) EC/SIDE -2012. LNCS, vol. 7269, pp. 222–230. Springer, Heidelberg (2012). doi:10.1007/978-3-642-29353-5_26

    Chapter  Google Scholar 

  9. Gorzałczany, M.B., Rudziński, F.: A modified pittsburg approach to design a genetic fuzzy rule-based classifier from data. In: Rutkowski, L., Scherer, R., Tadeusiewicz, R., Zadeh, L.A., Zurada, J.M. (eds.) ICAISC 2010. LNCS (LNAI), vol. 6113, pp. 88–96. Springer, Heidelberg (2010). doi:10.1007/978-3-642-13208-7_12

    Chapter  Google Scholar 

  10. Rudziński, F.: Finding sets of non-dominated solutions with high spread and well-balanced distribution using generalized strength Pareto evolutionary algorithm. In: Proceedings of the 16th World Congress of the International Fuzzy Systems Association (IFSA) and the 9th Conference of the European Society for Fuzzy Logic and Technology (EUSFLAT), IFSA-EUSFLAT 2015. Advances in Intelligent System Research, vol. 89, pp. 178–185. Atlantis Press, June 2015

    Google Scholar 

  11. Gorzałczany, M.B., Rudziński, F.: An improved multi-objective evolutionary optimization of data-mining-based fuzzy decision support systems. In: Proceedings of 2016 IEEE International Conference on Fuzzy Systems (FUZZ-IEEE), Vancouver, Canada, pp. 2227–2234, 25–29 July 2016

    Google Scholar 

  12. Gorzałczany, M.B., Rudziński, F.: A multi-objective-genetic-optimization-based data-driven fuzzy classifier for technical applications. In: Proceedings of 2016 IEEE 25th International Symposium on Industrial Electronics (ISIE), Santa Clara, CA, USA, pp. 78–83, 8–10 June 2016

    Google Scholar 

  13. Zitzler, E., Laumanns, M., Thiele, L.: SPEA2: improving the strength Pareto evolutionary algorithm for multiobjective optimization. In: Proceeding of the Evolutionary Methods for Design, Optimisation, and Control, CIMNE, Barcelona, Spain, pp. 95–100 (2002)

    Google Scholar 

  14. Crick, F.: Central dogma of molecular biology. Nature 227, 561–563 (1970)

    Article  Google Scholar 

  15. Leavitt, S.A.: Deciphering the Genetic Code: Marshall Nirenberg. Office of NIH History (2010). https://history.nih.gov/exhibits/nirenberg/glossary.htm

  16. Okabe, T., Jin, Y., Sendhoff, B.: A critical survey of performance indices for multi-objective optimisation. In: Proceedings of 2003 Congress on Evolutionary Computation, pp. 878–885. IEEE Press (2003)

    Google Scholar 

  17. Blasig, R.: GDS: gradient descent generation of symbolic classification rules. In: Cowan, J.D., Tesauro, G., Alspector, J. (eds.) Advances in Neural Information Processing Systems, vol. 6, pp. 1093–1100. Morgan-Kaufmann, San Mateo (1994)

    Google Scholar 

  18. Tanwani, A.K., Farooq, M.: Performance evaluation of evolutionary algorithms in classification of biomedical datasets. In: Proceedings of the 11th Annual Conference Companion on Genetic and Evolutionary Computation Conference (GECCO 2009), New York, NY, USA, pp. 2617–2624 (2009)

    Google Scholar 

  19. Huynh, T.Q., Reggia, J.A.: Improving rule extraction from neural networks by modifying hidden layer representations. In: Proceedings of 2009 International Joint Conference on Neural Networks, pp. 1316–1321 (2009)

    Google Scholar 

  20. Kerdprasop, N., Kerdprasop, K.: A high recall DNA splice site prediction based on association analysis. In: Proceedings of the 10th WSEAS International Conference on Applied Computer Science (ACS 2010), Stevens Point, Wisconsin, USA, pp. 484–489 (2010)

    Google Scholar 

  21. Gasparovica, M., Aleksejeva, L., Gersons, V.: The use of BEXA family algorithms in bioinformatics data classification. Inf. Technol. Manage. Sci. 15(1), 120–126 (2013)

    Google Scholar 

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Correspondence to Marian B. Gorzałczany .

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Gorzałczany, M.B., Rudziński, F. (2017). Classification of Splice-Junction DNA Sequences Using Multi-objective Genetic-Fuzzy Optimization Techniques. In: Rutkowski, L., Korytkowski, M., Scherer, R., Tadeusiewicz, R., Zadeh, L., Zurada, J. (eds) Artificial Intelligence and Soft Computing. ICAISC 2017. Lecture Notes in Computer Science(), vol 10245. Springer, Cham. https://doi.org/10.1007/978-3-319-59063-9_57

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  • DOI: https://doi.org/10.1007/978-3-319-59063-9_57

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