Abstract
This study aims to investigate if neural oscillations can play a role as a bridge between GABAergic systems and emotional behaviors. Mice were divided into streptozotocin-induced diabetes mellitus (DM) group and control (CON) group. After 8 weeks of successfully modeling, the diabetic mice exhibited depression and anxiety, while the GABAAR \( \alpha_{1} \) subunit expression and the GABA level were significantly changed as well. There were increase power percent at gamma (50–80 Hz) band in the power spectrum between these two groups. However, DM attenuated the identical-frequency strength of phase synchronization and information flow at both theta (8–13 Hz) and gamma rhythms, and reduced the theta-gamma phase-amplitude coupling strength either in the PP & DG regions or on PP-DG pathway. It suggests that DM changes the pattern of neural oscillations by modulating the GABAAR \( \alpha_{1} \) subunit expression and the GABA level in depression and anxiety in diabetic mice.
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Acknowledgement
This work was supported by grants from the National Natural Science Foundation of China (11232005, 31171053).
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Zhang, T., Li, Q., Yang, Z. (2017). Neural Oscillations as a Bridge Between GABAergic System and Emotional Behaviors. In: Cong, F., Leung, A., Wei, Q. (eds) Advances in Neural Networks - ISNN 2017. ISNN 2017. Lecture Notes in Computer Science(), vol 10262. Springer, Cham. https://doi.org/10.1007/978-3-319-59081-3_66
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DOI: https://doi.org/10.1007/978-3-319-59081-3_66
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